Agmatin Biyokimyası: Şizofreni ve Depresyondaki Rolüne Bakış

Yıl 2019, , 206 - 212, 28.06.2019

Erdem Çokluk , Ramazan Şekeroğlu , Emine Yılmaz

https://doi.org/10.31832/smj.461657

Öz

Agmatin imidazolin reseptör agonisti olup çok sayıda
reseptörle etkileşebilen nöroprotektif, anti-enflamatuvar, anti-stres,
anti-depresan özellikte, kognitif fonksiyonların düzenlenmesinde rol alan bir
moleküldür. Agmatinin beyindeki inaktivasyonu, reuptake mekanizmaları ve
enzimatik parçalanmayla gerçekleşmektedir. Gerialımı diğer
nörotransmitterlerden farklı olarak sıcaklığa bağlı gerçekleşmekte ve sadece
yüksek konsantrasyonlarda doygunluğa ulaşabilmektedir. Ayrıca, agmatinin
streste arttığı, dolayısıyla majör depresyon hastalarında akut dönemde tedavi
sonrası döneme göre plazma agmatin düzeylerinin daha yüksek olduğu da
bildirilmiştir. Bununla birlikte şizofreni gelişmeden önceki süreçte agmatin
eksikliğinden, şizofreni geliştikten sonraki dönemde ise agmatin artışından
bahseden çalışmalar da literatürde mevcuttur. Bu derlemede agmatinin
biyokimyası, şizofreni ve depresyondaki rolü ve 
nöroprotektif etkisi irdelenmiştir.

Anahtar Kelimeler

Agmatin, şizofreni, depresyon, nöroprotektif etki

Kaynakça

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