Evaluation of the quality of life of patients with postmenopausal osteoporosis

Abstract

Objective: In our study, we aimed to determine the postmenopausal osteoporosis (PMO) effect on quality of life using The International Osteoporosis Society Quality of Life Survey (QUALEFFO-41).

Materials and Methods: A total of 123 patients and 49 healthy women with PMO participated to our study. Bone mineral density was measured using dual energy X-ray absorptiometry (DXA). The demographic characteristics, educational status, occupational activities, age at menopause, duration, physical activity level, presence of PMO in family, fracture history in family and hospital, presence of treatment for PMO, and presence of movement system and systemic disease and chronic drug usage history of the patients were assessed. QUALEFFO-41 was used to assess the quality of life.

Results: The QUALEFFO-41 total score revealed a statistically significant correlation between exercise, age, age at menopause, menopause duration, and the t score and total score of the femur neck in DXA measurement. Age was the most important determinant of the quality of life.

Conclusion: In our study, we found that there are many factors that affect the quality of life in patients with PMO. Therefore, it will be appropriate to evaluate the patients in many ways. When planning the treatment of patients with PMO, factors affecting exercise and other quality of life should be considered in addition to drug therapy.

Keywords

• Osteoporosis,postmenopause,Quality of life

Postmenopozal Osteoporozlu Hastalarda Yaşam Kalitesinin Değerlendirilmesi

Abstract

Amaç: Çalışmamız Uluslararası Osteoporoz Derneği Yaşam Kalitesi Anketi (QUALEFFO-41) ile postmenopozal osteoporozun (PMO) yaşam kalitesi üzerindeki etkisinin anlaşılmasını amaçlamıştır.

Gereç ve yöntemler: Çalışmamıza PMO'lu toplam 123 hasta ve 49 sağlıklı kadın katıldı. Kemik mineral yoğunluğu dual energy X-ray absorptiometry (DXA) ile ölçüldü. Hastaların demografik özellikleri, eğitim durumu, mesleki faaliyetler, menopoz yaşı, süre, fiziksel aktivite düzeyi, ailede PMO varlığı, ailede ve hastanede kırık öyküsü, PMO için tedavinin varlığı, hareket sistemi ve sistemik hastalık varlığı ve kronik ilaç kullanım öyküsü sorgulandı. QUALEFFO-41 yaşam kalitesini değerlendirmek için kullanılmıştır.

Bulgular: Hastalarımızın demografik ve klinik verileri ile yaşam kalitesi puanları arasındaki değerlendirme sonucunda; QUALEFFO-41 toplam skoruyla DXA ölçümünde egzersiz, yaş, menopoz yaşı, menopoz süresi, femur boynu T skoru ve femur boynu toplam skoru arasında istatistiksel olarak anlamlı bir ilişki vardı. Yaş, yaşam kalitesinin en önemli belirleyicisi olarak belirlendi.

Sonuç: Çalışmamızda PMO’lu hastalarda yaşam kalitesini etkileyen bir çok faktör olduğunu tespit ettik. Bu yüzden hastaların çok yönlu olarak değerlendirilmesi uygun olacaktır. PMO'lu hastaların tedavisini planlarken, ilaç tedavisinin yanı sıra, egzersizde ve diğer yaşam kalitesini etkileyen faktörler de göz önünde bulundurulmalıdır.

Keywords

• Osteoporoz,postmenopoz,Yaşam Kalitesi

References

1. 1. Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. American journal of obstetrics and gynecology 2006;194:S3-S11.
2. 2. Papaioannou A, Joseph L, Ioannidis G, Berger C, Anastassiades T, Brown JP, et al. Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporosis international 2005;16:568-578.
3. 3. Bianchi ML, Orsini MR, Saraifoger S, Ortolani S, Radaelli G, Betti S. Quality of life in post-menopausal osteoporosis. Health and Quality of Life Outcomes 2005;3:78.
4. 4. Crans G, Silverman S, Genant H, Glass E, Krege J. Association of severe vertebral fractures with reduced quality of life: reduction in the incidence of severe vertebral fractures by teriparatide. Arthritis & Rheumatology 2004;50:4028-4034.
5. 5. Lips P, van Schoor NM. Quality of life in patients with osteoporosis. Osteoporosis International 2005;16:447-455.
6. 6. Kocyigit H, Gülseren Ş, Erol A, Hizli N, Memis A. The reliability and validity of the Turkish version of Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Clinical rheumatology 2003;22:18-23.
7. 7. Oglesby AK, Minshall ME, Shen W, Xie S, Silverman SL. The impact of incident vertebral and non-vertebral fragility fractures on health-related quality of life in established postmenopausal osteoporosis: results from the teriparatide randomized, placebo-controlled trial in postmenopausal women. The Journal of rheumatology 2003;30:1579-1583.
8. 8. Oleksik AM, Ewing S, Shen W, van Schoor NM, Lips P. Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporosis international 2005;16:861-870.

9. 9.Paker N, Bugdayci D, Dere D, Tekdöş D, Erbil E, Dere Ç. Relationship between bone density and quality of life in postmenopausal osteoporosis. Turkish Journal of Geriatrics/Türk Geriatri Dergisi 2012;15.
10. 10.Organization WH. Report of a WHO Scientific Group. Research on the Menopause in the 1990s. WHO technical report series 1996;866.
11. 11.Fechtenbaum J, Cropet C, Kolta S, Horlait S, Orcel P, Roux C. The severity of vertebral fractures and health-related quality of life in osteoporotic postmenopausal women. Osteoporosis International 2005;16:2175-2179.
12. 12.Borgström F, Lekander I, Ivergård M, Ström O, Svedbom A, Alekna V, et al. The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—quality of life during the first 4 months after fracture. Osteoporosis international 2013;24:811-823
13. Petronijević M, Petronijević N, Ivković M, Stefanović D, Radonjić N, Glišić B, et al. Low bone mineral density and high bone metabolism turnover in premenopausal women with unipolar depression. Bone 2008;42:582-590
14. 14.Silverman SL. Quality-of-life issues in osteoporosis. Current rheumatology reports 2005;7:39-45.
15. 15.Ohta H, Uemura Y, Nakamura T, Fukunaga M, Ohashi Y, Hosoi T, et al. Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture. Clinical therapeutics 2014;36:225-235.
16. 16.Nuti R, Caffarelli C, Guglielmi G, Gennari L, Gonnelli S. Undiagnosed vertebral fractures influence quality of life in postmenopausal women with reduced ultrasound parameters. Clinical Orthopaedics and Related Research® 2014;472:2254-2261.
17. 17.Buatois S, Gueguen R, Gauchard GC, Benetos A, Perrin PP. Posturography and risk of recurrent falls in healthy non-institutionalized persons aged over 65. Gerontology 2006;52:345-352.
18. 18.Kolotkin RL, Andersen JR. A systematic review of reviews: exploring the relationship between obesity, weight loss and health‐related quality of life. Clinical obesity 2017;7:273-289.
19. 19.Al-Sari UA, Tobias J, Clark E. Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis. Osteoporos Int 2016;27:2891-2900.
20. 20.Van Schoor N, Smit J, Twisk J, Lips P. Impact of vertebral deformities, osteoarthritis, and other chronic diseases on quality of life: a population-based study. Osteoporosis international 2005;16:749-756
21. 21.Krum SA, Brown M. Unraveling estrogen action in osteoporosis. Cell Cycle 2008;7:1348-1352. 22. Huffman F, Vaccaro J, Zarini G, Vieira E. Osteoporosis, Activities of Daily Living Skills, Quality of Life, and Dietary Adequacy of Congregate Meal Participants. Geriatrics 2018;3:24.
22. 22.Huffman F, Vaccaro J, Zarini G, Vieira E. Osteoporosis, Activities of Daily Living Skills, Quality of Life, and Dietary Adequacy of Congregate Meal Participants. Geriatrics 2018;3:24.
23. 23.Rizzoli R. Postmenopausal osteoporosis: assessment and management. Best Practice & Research Clinical Endocrinology & Metabolism 2018.
24. 24.Palacios S, Neyro J, Fernandez de Cabo S, Chaves J, Rejas J. Impact of osteoporosis and bone fracture on health-related quality of life in postmenopausal women. Climacteric 2014;17:60-70.
25. 25.Guirant L, Carlos F, Curiel D, Kanis JA, Borgström F, Svedbom A, et al. Health-related quality of life during the first year after a hip fracture: results of the Mexican arm of the International Cost and Utility Related to Osteoporotic Fractures Study (MexICUROS). Osteoporosis International 2018;29:1147-1154.
26. 26.Preisinger E. Physiotherapie und Bewegung bei Osteoporose und Folgeerkrankungen. Zeitschrift für Rheumatologie 2009;68:534-538.
27. 27.Uhlemann C, Lange U. Differenzialindikative physikalische Therapiestrategien der Osteoporose–Empfehlungen für den Praxisalltag. Zeitschrift für Rheumatologie 2006;65:407-416.
28. 28.Mack DE, Wilson PM, Gunnell KE. Land of confusion: unpacking the relationship between physical activity and well-being in individuals living with osteoporosis. International Review of Sport and Exercise Psychology 2017;10:212-229.