Araştırma Makalesi
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Yıl 2020, , 264 - 269, 15.06.2020
https://doi.org/10.31832/smj.674963

Öz

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • 1. Hudaib M, Speroni E, Di Pietra AM, Cavrini V. GC/MS evaluation of thyme (Thymusvulgaris L.) oil composition and variations during the vegetative cycle. J Pharm Biomed Anal. 2002; 29: 691-700. doi:10.1016/S0731-7085(02)00119-X.
  • 2. Cragg, G.M. and Newman DJ. Biodiversity: A continuing source of novel drug leads. Pure Appl Chem. 2005; 77: 7–24. doi:10.1016/S0045-6535(97)00048-9.
  • 3. Kassis E, Fulder S, Khalil K, Hadieh B, Nahhas F, Saad B, et al. Efficacy and Safety Assessments of Ferula assa-foetida L., Traditionally used in Greco-Arab Herbal Medicine for Enhancing Male Fertility, Libido and Erectile Function. Open Complement Med J. 2009;1:102–109. https://benthamopen.com/contents/pdf/TOALTMEDJ/TOALTMEDJ-1-102.pdf. Accessed 5 Oct 2018.
  • 4. Geroushi A, Auzi AA, Elhwuegi AS, Elzawam F, Elsherif A, Nahar L, Sarker SD.. Antiinflammatory Sesquiterpenes from the Root Oil of Ferula Hermonis. Phytother. Res., 2011; 25: 774-777. doi:10.1002/ptr.3324.
  • 5. Ibraheim ZZ, Abdel-Mageed WM, Dai H, Guo H, Zhang L, Jaspars M. Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss. Phyther Res. 2012; 26: 579–586. doi:10.1002/ptr.3609.
  • 6. Sitara U, Niaz I, Naseem J, Sultana N. Antifungal effect of essential oils on in vitro growth of pathogenic fungi. Pakistan J Bot. 2008; 40: 409-414.
  • 7. El-Thaher TS, Matalka KZ, Taha HA, Badwan AA. Ferula harmonis “zallouh” and enhancing erectile function in rats: Efficacy and toxicity study. Int J Impot Res. 2001; 13: 247-251. doi:10.1038/sj.ijir.3900706.
  • 8. JJain S, Pandhi P, Singh AP, Malhorta S. Efficacy of standardise herbal extracts in type 1 diabetes - An experimental study. African J Tradit Complement Altern Med. 2006; 3: 23-33. doi:index.php/ajtcam/article/view/138.
  • 9. Başer KHC, Özek T, Demirci B, Kürkçüolu M, Aytaç Z, Duman H. Composition of the essential oils of Zosima absinthifolia (Vent.) Link and Ferula elaeochytris Korovin from Turkey. Flavour Fragr J. 2000; 15(6): 371–372.
  • 10. Eser N, Yoldas A. Identification of heat-resistant chemical components of Ferula elaeochytris root extracts by gas chromatography- mass spectrometry. Trop J Pharm Res. 2019; 18(1): 55–60.
  • 11. Deveci E. Essential oil composition , antioxidant , anticholinesterase and anti-tyrosinase activities of two Turkish plant species : Ferula elaeochytris and sideritis stricta. 2019; 13: 101-104. doi:10.1177/1934578X1801300130.
  • 12. Eser N, Buyuknacar HS, Cimentepe OO, Gocmen C, Ucar Y, Erdogan S, et al. The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat. International journal of impotence research. https://doi.org/10.1038/s41443-019-0137-8.
  • 13. Alkhatib R, Hennebelle T, Joha S, Idziorek T, Preudhomme C, Quesnel B, et al. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines. Phytochemistry. 2008; 69: 2979. doi:10.1016/j.phytochem.2008.09.019.
  • 14. Khoury M, El Beyrouthy M, Eparvier V, Ouaini N, Stien D. Chemical diversity and antimicrobial activity of the essential oils of four Apiaceae species growing wild in Lebanon. J Essent Oil Res. 2018; 25-31. https://doi.org/10.1080/10412905.2017.1372314
  • 15. Klevenhusen F, Deckardt K, Sizmaz, Wimmer S, Muro-Reyes A, Khiaosa-Ard R, et al. Effects of black seed oil and Ferula elaeochytris supplementation on ruminal fermentation as tested in vitro with the rumen simulation technique (Rusitec). Anim Prod Sci. 2015; 55: 736-744. doi:10.1071/AN13332..
  • 16. Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, et al. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology. 2001; 142: 3590-3597. doi:10.1210/endo.142.8.8293.
  • 17. Clifton P. Dietary fatty acids and inflammation. Nutrition and Dietetics. 2009; 66: 7–11. https://doi.org/10.1111/j.1747-0080.2008.01311.x
  • 18. Martin‐Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez‐Artalejo F, Fernandez‐Rodriguez JC, et al. Dietary fat, olive oil intake and breast cancer risk. Int J Cancer. 1994; 58: 774-780. doi:10.1002/ijc.2910580604
  • 19. Coupland K, Wilson R. Nervonic acid and demyelinating disease. Med Hypotheses. 1994; 42(4): 237-242.
  • 20. Amminger GP, Schäfer MR, Klier CM, Slavik JM, Holzer I, Holub M, et al. Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals. Molecular Psychiatry. 2012; 17(12): 1150-1152. doi:10.1038/mp.2011.167.
  • 21. Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012; 27(202): 326-333. doi: 10.1016/j.neuroscience.2011.12.002. Epub 2011 Dec 13.
  • 22. Cavanagh HMA, Wilkinson JM. Biological activities of lavender essential oil. Phytotherapy Research. 2002; 58: 774-780. doi:10.1002/ijc.2910580604.
  • 23. Dauqan E, Sani HA, Abdullah A, Kasim ZM. Effect of Different Vegetable Oils (Red Palm Olein, Palm Olein, Corn Oil and Coconut Oil) on Lipid Profile in Rat. Food Nutr Sci. 2011; 2(4): 1-6. doi:10.4236/fns.2011.24036
  • 24. Bimakr M, Rahman RA, Taip FS, Ganjloo A, Salleh LM, Selamat J, Hamid A, et al. Comparison of different extraction methods for the extraction of major bioactive flavonoid compounds from spearmint (Menthaspicata L.) leaves. Food Bioprod. Process. 2011; 89: 67-72.
  • 25. Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacological Research. 1999; 40(3): 211-225.
  • 26. Oda E, Harada K, Kimura J, Aizawa Y, Veeraveedu P, Watanabe K. Relationships Between Serum Unsaturated Fatty Acids and Coronary Risk Factors Negative Relations Between Nervonic Acid and Obesity-Related Risk Factors. Int Heart J. 2005; 46(6): 975-985.
  • 27. Mancini A, Imperlini E, Nigro E, Montagnese C, Daniele A, Orrù S, et al. Biological and nutritional properties of palm oil and palmitic acid: Effects on health. Molecules. 2015; 18; 20(9): 17339-17361. doi: 10.3390/molecules200917339.
  • 28. Jandacek RJ. Linoleic Acid: A Nutritional Quandary. Healthcare. 2017; 5: 25. doi:10.3390/healthcare5020025.
  • 29. Burdge GC, Calder PC. Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutr Res Rev. 2006; 19: 26. doi:10.1079/NRR2005113.
  • 30. Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VHC.. Antioxidative Activities of Both Oleic Acid and Camellia Tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis Elegans. PLoS One, 2016; 8: e0157195. doi:10.1371/journal.pone.0157195.
  • 31. Busnello FM, Santos ZE de A, Pontin B. Handbook of Lipids in Human Function. 2016; doi:10.1016/B978-1-63067-036-8.00020-2.
  • 32. Escrich E, Raquel M, Laura G, Irmgard C, Solanas M. Molecular Mechanisms of the Effects of Olive Oil and Other Dietary Lipids on Cancer. Mol. Nutr. Food. Res., 2007; 51: 1279–1292. doi:10.1002/mnfr.200700213.
  • 33. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake. Diabetes, 2002; 51: 271-275. doi:10.2337/diabetes.51.2.271.
  • 34. Hashimoto M, Hossain S, Agdul H, Shido O. Docosahexaenoic Acid-Induced Amelioration on Impairment of Memory Learning in Amyloid β-Infused Rats Relates to the Decreases of Amyloid β and Cholesterol Levels in Detergent-Insoluble Membrane Fractions. Biochim. Biophys. Acta., 2005; 1738: 91-98. doi:10.1016/j.bbalip.2005.11.011.
  • 35. Kageyama Y, Kasahara T, Nakamura T, Hattori K, Deguchi Y, Tani M, et al. Plasma nervonic acid is a potential biomarker for major depressive disorder: A pilot study. Int J Neuropsychopharmacol. 2018; 1;21(3): 207-215. doi: 10.1093/ijnp/pyx089.
  • 36. Cater NB, Denke MA. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001; 73(1): 41-44.
  • 37. Bralley J. Laboratory evaluations in molecular medicine : nutrients, toxicants, and cell regulators. Norcross GA: Institute for Advances in Molecular Medicine; 2005; https://www.worldcat.org/title/laboratory-evaluations-in-molecular-medicine-nutrients-toxicants-and-cell-regulators/oclc/62864801. Accessed 31 Mar 2019.
  • 38. Ernst E. Textbook of Natural Medicine. Focus Altern Complement Ther. 2010.
  • 39. Charytan C, Purtilo D. Glomerular Capillary Thrombosis and Acute Renal Failure after Epsilon-Amino Caproic Acid Therapy. N Engl J Med. 1969; 280: 1102-1104 DOI: 10.1056/NEJM196905152802006
  • 40. De Meester F, Watson RR. Handbook of Lipids in Human Function: Fatty Acids. 2015.
  • 41. Brown DG, Rao S, Weir TL, O’Malia J, Bazan M, Brown RJ, et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016; 6(4): 11. doi: 10.1186/s40170-016-0151-y.
  • 42. Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? Br J Clin Pharmacol. 2013; 75: 645–662.
  • 43. De Pablo P, Romaguera D, Fisk HL, Calder PC, Quirke AM, Cartwright AJ, et al. High erythrocyte levels of the n-6 polyunsaturated fatty acid linoleic acid are associated with lower risk of subsequent rheumatoid arthritis in a Southern European nested case–control study. Ann Rheum Dis. 2018; 77: 981–987.
  • 44. Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins, Leukot Essent Fat Acids. 2018; 132: 41–48. doi:10.1016/j.plefa.2018.03.004.
  • 45. Derbyshire E. Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements. Nutrients. 2018; 10: 1094. doi:10.3390/nu10081094.

GC/FID ile ekstrakte edilen Ferula elaeochytris kök ekstresinden yağ asidlerinin analizi

Yıl 2020, , 264 - 269, 15.06.2020
https://doi.org/10.31832/smj.674963

Öz

Amaç: Birçok hastalığın tedavisinde yerel halk tarafından yaygın olarak kullanılan Ferula elaeochytris kökü (FE), yağları ve oleoresinleri içermesi yönüyle güçlü bir aromatik kokuya sahiptir. Bu çalışmada, Ferula elaeochytris kök ekstresinin yağ asidi bileşenlerini ve insan vücudu için önemini belirlemek amaçlandı.
Gereç ve Yöntemler: Bu çalışmada, Kahramanmaraş’ın Engizek platosundan toplanan Ferula elaeochytris bitkisinin kök kısmı kurutulup, öğütülerek hazırlanan kök ekstresinin yağ asidi profili, Alev İyonizasyon Dedektörleri (GC-FID) ile donatılmış bir Gaz Kromatografisi kullanılarak analiz edildi.
Bulgular: Yapılan analiz sonucunda 9 adet doymamış, 7 adet doymuş toplam 16 yağ asidi belirlenmiştir. Doymamış (% 56,25) yağ içeriği, doymuş yağdan (% 43,75) daha yüksek bulundu. insan vücudunun besin ihtiyacının sağlanması için gereken doymamış yağ asidi olarak Omega-6'dan türetilmiş linoleik asit (% 39,25) ve omega-3 türevi alfa-linolenik asit (% 2,390) içeriği yüksek iken, omega-9 türevi oleik asit (15.79) en bol bulunan ikinci sıra yağ asidi olarak bulunmuştur. Bu bitki ayrıca sinir sisteminin gelişimi ve bozuklukları için önemli olan Nervonik asit (% 0.599) içermektedir. Palmatik asit (% 10,506), doymamış yağ asitleri arasında en yüksek seviyelerde bulundu.
Sonuç: Yapılan bu çalışmada, insan sağlığında birçok yararlı etkileri gösterilen Ferula elaeochytris bitkisi içeriğindeki major komponentler, GC-FID ile yapılan analiz ile gösterilmiştir.

Proje Numarası

-

Kaynakça

  • 1. Hudaib M, Speroni E, Di Pietra AM, Cavrini V. GC/MS evaluation of thyme (Thymusvulgaris L.) oil composition and variations during the vegetative cycle. J Pharm Biomed Anal. 2002; 29: 691-700. doi:10.1016/S0731-7085(02)00119-X.
  • 2. Cragg, G.M. and Newman DJ. Biodiversity: A continuing source of novel drug leads. Pure Appl Chem. 2005; 77: 7–24. doi:10.1016/S0045-6535(97)00048-9.
  • 3. Kassis E, Fulder S, Khalil K, Hadieh B, Nahhas F, Saad B, et al. Efficacy and Safety Assessments of Ferula assa-foetida L., Traditionally used in Greco-Arab Herbal Medicine for Enhancing Male Fertility, Libido and Erectile Function. Open Complement Med J. 2009;1:102–109. https://benthamopen.com/contents/pdf/TOALTMEDJ/TOALTMEDJ-1-102.pdf. Accessed 5 Oct 2018.
  • 4. Geroushi A, Auzi AA, Elhwuegi AS, Elzawam F, Elsherif A, Nahar L, Sarker SD.. Antiinflammatory Sesquiterpenes from the Root Oil of Ferula Hermonis. Phytother. Res., 2011; 25: 774-777. doi:10.1002/ptr.3324.
  • 5. Ibraheim ZZ, Abdel-Mageed WM, Dai H, Guo H, Zhang L, Jaspars M. Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss. Phyther Res. 2012; 26: 579–586. doi:10.1002/ptr.3609.
  • 6. Sitara U, Niaz I, Naseem J, Sultana N. Antifungal effect of essential oils on in vitro growth of pathogenic fungi. Pakistan J Bot. 2008; 40: 409-414.
  • 7. El-Thaher TS, Matalka KZ, Taha HA, Badwan AA. Ferula harmonis “zallouh” and enhancing erectile function in rats: Efficacy and toxicity study. Int J Impot Res. 2001; 13: 247-251. doi:10.1038/sj.ijir.3900706.
  • 8. JJain S, Pandhi P, Singh AP, Malhorta S. Efficacy of standardise herbal extracts in type 1 diabetes - An experimental study. African J Tradit Complement Altern Med. 2006; 3: 23-33. doi:index.php/ajtcam/article/view/138.
  • 9. Başer KHC, Özek T, Demirci B, Kürkçüolu M, Aytaç Z, Duman H. Composition of the essential oils of Zosima absinthifolia (Vent.) Link and Ferula elaeochytris Korovin from Turkey. Flavour Fragr J. 2000; 15(6): 371–372.
  • 10. Eser N, Yoldas A. Identification of heat-resistant chemical components of Ferula elaeochytris root extracts by gas chromatography- mass spectrometry. Trop J Pharm Res. 2019; 18(1): 55–60.
  • 11. Deveci E. Essential oil composition , antioxidant , anticholinesterase and anti-tyrosinase activities of two Turkish plant species : Ferula elaeochytris and sideritis stricta. 2019; 13: 101-104. doi:10.1177/1934578X1801300130.
  • 12. Eser N, Buyuknacar HS, Cimentepe OO, Gocmen C, Ucar Y, Erdogan S, et al. The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat. International journal of impotence research. https://doi.org/10.1038/s41443-019-0137-8.
  • 13. Alkhatib R, Hennebelle T, Joha S, Idziorek T, Preudhomme C, Quesnel B, et al. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines. Phytochemistry. 2008; 69: 2979. doi:10.1016/j.phytochem.2008.09.019.
  • 14. Khoury M, El Beyrouthy M, Eparvier V, Ouaini N, Stien D. Chemical diversity and antimicrobial activity of the essential oils of four Apiaceae species growing wild in Lebanon. J Essent Oil Res. 2018; 25-31. https://doi.org/10.1080/10412905.2017.1372314
  • 15. Klevenhusen F, Deckardt K, Sizmaz, Wimmer S, Muro-Reyes A, Khiaosa-Ard R, et al. Effects of black seed oil and Ferula elaeochytris supplementation on ruminal fermentation as tested in vitro with the rumen simulation technique (Rusitec). Anim Prod Sci. 2015; 55: 736-744. doi:10.1071/AN13332..
  • 16. Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, et al. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology. 2001; 142: 3590-3597. doi:10.1210/endo.142.8.8293.
  • 17. Clifton P. Dietary fatty acids and inflammation. Nutrition and Dietetics. 2009; 66: 7–11. https://doi.org/10.1111/j.1747-0080.2008.01311.x
  • 18. Martin‐Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez‐Artalejo F, Fernandez‐Rodriguez JC, et al. Dietary fat, olive oil intake and breast cancer risk. Int J Cancer. 1994; 58: 774-780. doi:10.1002/ijc.2910580604
  • 19. Coupland K, Wilson R. Nervonic acid and demyelinating disease. Med Hypotheses. 1994; 42(4): 237-242.
  • 20. Amminger GP, Schäfer MR, Klier CM, Slavik JM, Holzer I, Holub M, et al. Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals. Molecular Psychiatry. 2012; 17(12): 1150-1152. doi:10.1038/mp.2011.167.
  • 21. Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012; 27(202): 326-333. doi: 10.1016/j.neuroscience.2011.12.002. Epub 2011 Dec 13.
  • 22. Cavanagh HMA, Wilkinson JM. Biological activities of lavender essential oil. Phytotherapy Research. 2002; 58: 774-780. doi:10.1002/ijc.2910580604.
  • 23. Dauqan E, Sani HA, Abdullah A, Kasim ZM. Effect of Different Vegetable Oils (Red Palm Olein, Palm Olein, Corn Oil and Coconut Oil) on Lipid Profile in Rat. Food Nutr Sci. 2011; 2(4): 1-6. doi:10.4236/fns.2011.24036
  • 24. Bimakr M, Rahman RA, Taip FS, Ganjloo A, Salleh LM, Selamat J, Hamid A, et al. Comparison of different extraction methods for the extraction of major bioactive flavonoid compounds from spearmint (Menthaspicata L.) leaves. Food Bioprod. Process. 2011; 89: 67-72.
  • 25. Horrocks LA, Yeo YK. Health benefits of docosahexaenoic acid (DHA). Pharmacological Research. 1999; 40(3): 211-225.
  • 26. Oda E, Harada K, Kimura J, Aizawa Y, Veeraveedu P, Watanabe K. Relationships Between Serum Unsaturated Fatty Acids and Coronary Risk Factors Negative Relations Between Nervonic Acid and Obesity-Related Risk Factors. Int Heart J. 2005; 46(6): 975-985.
  • 27. Mancini A, Imperlini E, Nigro E, Montagnese C, Daniele A, Orrù S, et al. Biological and nutritional properties of palm oil and palmitic acid: Effects on health. Molecules. 2015; 18; 20(9): 17339-17361. doi: 10.3390/molecules200917339.
  • 28. Jandacek RJ. Linoleic Acid: A Nutritional Quandary. Healthcare. 2017; 5: 25. doi:10.3390/healthcare5020025.
  • 29. Burdge GC, Calder PC. Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutr Res Rev. 2006; 19: 26. doi:10.1079/NRR2005113.
  • 30. Wei CC, Yen PL, Chang ST, Cheng PL, Lo YC, Liao VHC.. Antioxidative Activities of Both Oleic Acid and Camellia Tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis Elegans. PLoS One, 2016; 8: e0157195. doi:10.1371/journal.pone.0157195.
  • 31. Busnello FM, Santos ZE de A, Pontin B. Handbook of Lipids in Human Function. 2016; doi:10.1016/B978-1-63067-036-8.00020-2.
  • 32. Escrich E, Raquel M, Laura G, Irmgard C, Solanas M. Molecular Mechanisms of the Effects of Olive Oil and Other Dietary Lipids on Cancer. Mol. Nutr. Food. Res., 2007; 51: 1279–1292. doi:10.1002/mnfr.200700213.
  • 33. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake. Diabetes, 2002; 51: 271-275. doi:10.2337/diabetes.51.2.271.
  • 34. Hashimoto M, Hossain S, Agdul H, Shido O. Docosahexaenoic Acid-Induced Amelioration on Impairment of Memory Learning in Amyloid β-Infused Rats Relates to the Decreases of Amyloid β and Cholesterol Levels in Detergent-Insoluble Membrane Fractions. Biochim. Biophys. Acta., 2005; 1738: 91-98. doi:10.1016/j.bbalip.2005.11.011.
  • 35. Kageyama Y, Kasahara T, Nakamura T, Hattori K, Deguchi Y, Tani M, et al. Plasma nervonic acid is a potential biomarker for major depressive disorder: A pilot study. Int J Neuropsychopharmacol. 2018; 1;21(3): 207-215. doi: 10.1093/ijnp/pyx089.
  • 36. Cater NB, Denke MA. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001; 73(1): 41-44.
  • 37. Bralley J. Laboratory evaluations in molecular medicine : nutrients, toxicants, and cell regulators. Norcross GA: Institute for Advances in Molecular Medicine; 2005; https://www.worldcat.org/title/laboratory-evaluations-in-molecular-medicine-nutrients-toxicants-and-cell-regulators/oclc/62864801. Accessed 31 Mar 2019.
  • 38. Ernst E. Textbook of Natural Medicine. Focus Altern Complement Ther. 2010.
  • 39. Charytan C, Purtilo D. Glomerular Capillary Thrombosis and Acute Renal Failure after Epsilon-Amino Caproic Acid Therapy. N Engl J Med. 1969; 280: 1102-1104 DOI: 10.1056/NEJM196905152802006
  • 40. De Meester F, Watson RR. Handbook of Lipids in Human Function: Fatty Acids. 2015.
  • 41. Brown DG, Rao S, Weir TL, O’Malia J, Bazan M, Brown RJ, et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016; 6(4): 11. doi: 10.1186/s40170-016-0151-y.
  • 42. Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? Br J Clin Pharmacol. 2013; 75: 645–662.
  • 43. De Pablo P, Romaguera D, Fisk HL, Calder PC, Quirke AM, Cartwright AJ, et al. High erythrocyte levels of the n-6 polyunsaturated fatty acid linoleic acid are associated with lower risk of subsequent rheumatoid arthritis in a Southern European nested case–control study. Ann Rheum Dis. 2018; 77: 981–987.
  • 44. Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins, Leukot Essent Fat Acids. 2018; 132: 41–48. doi:10.1016/j.plefa.2018.03.004.
  • 45. Derbyshire E. Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements. Nutrients. 2018; 10: 1094. doi:10.3390/nu10081094.
Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Nadire Eser

Atila Yoldaş

Ferudun Koçer 0000-0002-8749-7106

Proje Numarası -
Yayımlanma Tarihi 15 Haziran 2020
Gönderilme Tarihi 14 Ocak 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

AMA Eser N, Yoldaş A, Koçer F. GC/FID ile ekstrakte edilen Ferula elaeochytris kök ekstresinden yağ asidlerinin analizi. Sakarya Tıp Dergisi. Haziran 2020;10(2):264-269. doi:10.31832/smj.674963

30703

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