Correlation Between Liver Fibrosis and Mean Platelet Volume in Autoimmune Hepatitis Patients

Abstract

Objective: This study was carried out in order to assess the usability of platelet parameters and other biochemical values as predictive parameters in the evaluation of hepatic damage in autoimmune hepatitis (AIH) patients. Materials and Methods: We devised a retrospective descriptive and methodological study of cross-sectional type over the histological findings, laboratory and clinical parameters of AIH patients at our gastroenterology clinic. As per the analysis carried out using the scoring classification, the patients with a histological activity index (HAI) of 0-12 were identified as low activity, and the patients with a HAI of 13-18 as high activity. The patients with a fibrosis score of 0-2 were identified as early fibrosis, while those having a fibrosis score of 3-6 were identified as advanced fibrosis, and comparisons were made accordingly. Results: In patients with AIH, the levels of mean platelet volume (MPV) in the group showing high HAI scores were found to be higher compared to the group showing low activity (p=0.013). There was a statistically significant difference in terms of MPV levels between the fibrosis classes in patients with AIH (p=0.034). When the values of the areas below the ROC curve as well as the sensitivity and specificity of the MPV measurements were analyzed with regard to distinguishing the patients with AIH that were at high activity levels in the HAI classification and the patients at the advanced fibrosis level as per the fibrosis classification, they were found to be statistically significant. Discussion: A positive correlation was found when the MPV values of the patients with AIH were compared to the group showing a high activity as per the HAI classification. A positive correlation was found when the MPV values in the patients with AIH were compared to the group showing advanced fibrosis as per the fibrosis classification.

Keywords

• autoimmune hepatitis
• fibrosis
• mean platelet volume

Otoimmün Hepatit Hastalarında Karaciğer Fibrozisi ile Ortalama Trombosit Hacmi Arasındaki Korelasyon

Abstract

Giriş: Bu çalışma trombosit parametreleri ve diğer biyokimyasal değerlerin otoimmün hepatit (OH) hastalarında karaciğer hasarının değerlendirilmesinde prediktif bir parametre olarak kullanılabilirliğini değerlendirmek amacıyla yapıldı. Gereç ve Yöntemler: Gastroenteroloji kliniğimizde OH hastalarının histolojik bulguları laboratuvar ve klinik parametreleri üzerinden retrospektif kesitsel tipte tanımlayıcı ve metodolojik bir çalışma planladık. Skorlama sınıflamasıyla yapılan değerlendirmeye göre, 0 ile 12 arasında histolojik aktivite indeksi (HAI) olan hastalar düşük aktivite, 13 ile 18 arasında HAI olan hastalar yüksek aktivite olarak tanımlandı. Fibrozis skoru 0-2 olan hastalar erken fibrozis, fibrozis skoru 3 ile 6 arasında olanlar ileri fibrozis olarak tanımlanmış ve buna göre karşılaştırmalar yapılmıştır. Bulgular: Otoimmün hepatitli hastalarda HAI skoru yüksek aktivite gösteren grupta ortalama trombosit hacmi (MPV) düzeyleri düşük aktivite gösteren gruba göre daha yüksek saptanmıştır (p=0,013). Otoimmün hepatitli hastalarda fibrozis sınıfları arasında MPV düzeyleri açısından istatistiksel olarak anlamlı bir fark saptanmıştır (p=0,034). Otoimmün hepatitli hastalarda HAI sınıflamasında yüksek aktivite ve fibrozis sınıflamasına göre ileri fibrozis düzeyinde olan hastaları ayırt etmede MPV ölçümlerinin ROC eğrisi altında kalan alan değerleri, sensitivite ve spesifitesi incelendiğinde istatistiksel olarak anlamlı olduğu saptanmıştır. Tartışma: Otoimmün hepatitli hastalarda MPV değerlerinin HAI sınıflamasına göre yüksek aktivite gösteren grup ile karşılaştırıldığında pozitif korelasyon saptanmıştır. Otoimmün hepatitli hastalarda MPV değerlerinin fibrozis sınıflamasına göre ileri fibrozis gösteren grup ile karşılaştırıldığında pozitif korelasyon saptanmıştır.

Keywords

• otoimmün hepatit
• fibrozis
• ortalama trombosit hacmi

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