Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?

Abstract

Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP). Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxidant, inflammatory and antioxidant parameters were determined in lung and renal tissues. Results: Oxidant and inflammatory biomarkers increased while antioxidant biomarkers decreased in CLP and DMSO groups compared to sham group. Antioxidant parameters increased while oxidant and inflammatory biomarkers declined in treatment group compared to CLP and DMSO groups. Conclusion: Present results have demonstrated that URA administration is effective against lung and renal injuries caused by CLP-related polymicrobial sepsis model.

Keywords

• urapidil
• cecal ligation and puncture
• lung
• renal
• rat

Urapidil Çekal Ligasyon ve Delme ile İndüklenen Akciğer ve Böbrek Hasarını Hafifletir mi?

Abstract

Amaç: Burada, çekal ligasyon ve ponksiyonun (CLP) neden olduğu akciğer ve böbrek yaralanmalarına karşı Urapidil'in olası koruyucu etkileri araştırıldı. Materyal ve Metod: 32 Sprague Dawley erkek sıçan sham, CLP, Dimetil sülfoksit (DMSO) ve Urapidil (URA) 0.5 mg/kg şeklinde 4 gruba ayrıldı. Akciğer ve böbrek dokularında çeşitli oksidan, inflamatuvar ve antioksidan parametreler belirlendi. Bulgular: CLP ve DMSO gruplarında sham grubuna göre oksidan ve inflamatuvar biyobelirteçler artarken antioksidan biyobelirteçler azalmıştır. Tedavi grubunda CLP ve DMSO gruplarına göre antioksidan parametreler artarken oksidan ve inflamatuvar biyobelirteçler azaldı. Sonuç: Mevcut sonuçlar, URA uygulamasının CLP ile ilişkili polimikrobiyal sepsis modelinin neden olduğu akciğer ve böbrek hasarlarına karşı etkili olduğunu göstermiştir.

Keywords

• urapidil
• çekal ligasyon ve delme
• akciğer
• böbrek
• sıçan

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