Şizofreni Hastalarında Brugada EKG Paterni ve Fragmente QRS İlişkisi

Yıl 2021, , 97 - 102, 22.03.2021

Osman Bektaş , Ahmet Kaya , Esra Yancar Demir , Seçkin Dereli

https://doi.org/10.31832/smj.792890

Öz

Amaç: Şizofreni, ölümcül ritim bozuklukları ve ani kardiyak ölüm riski yüksek olan psikiyatrik bir hastalıktır. Brugada sendromunun şizofreni hastalarında oldukça yaygın olduğunu düşünülmektedir. Bu çalışmada şizofreni hastalarında Brugada sendromu ve fraqmanted QRS prevelansını araştırmayı amaçladık.
Yöntemler: Psikiyatri kliniğinde izlenen iki yüz elli şizofreni hastası ve 400 yaş ve cinsiyet uyumlu şizofreni olmayan kontrol grubu çalışmaya dahil edildi. Standart EKG'ler ve iki interkostal aralığın üzerinde V1 ve V2 derivasyonu olan yüksek interkostal EKG'ler alındı.
Bulgular: Şizofreni hastalarında Tip 1 Brugada sendromu gözlenmedi, bir hastada Tip 2 Brugada, iki hastada Tip 3 Brugada gözlendi. Kontrol grubunda bir hastada Tip 2 Brugada paterni belirlendi ve yine bir kontrol hastasında Tip 3 Brugada paterni vardı (p = 0.320). Fragmented QRS (fQRS) insidansı, QRS süresi ve düzeltilmiş QT'nin şizofreni grubunda kontrol grubuna göre daha yüksek olduğu gözlendi (sırasıyla p = 0.001, p = 0.003, p <0.001).
Sonuç: Şizofreni hastalarında Brugada EKG paterninin prevalansında artış yoktur. Şizofreni hastalarında fQRS prevelansı kontrol grubuna göre anlamlı olarak daha yüksekti. FQRS bulunan şizofreni hastalarının kardiyovasküler olay sıklığını öngörmede kullanılabilir.

Anahtar Kelimeler

şizofreni, brugada, fragmente qrs

The Relations of Brugada ECG Pattern and Fraqmented QRS in Patient with Schizophrenia

Öz

Objective: Schizophrenia is a psychiatric disease with high risk of fatal rhythm disorders and sudden cardiac death. A previous study reported that Brugada syndrome was highly prevelant in patients with schizophrenia. In this study we aimed to investigate the prevelance of Brugada syndrome and fraqmanted QRS in patients with schizophrenia.
Methods: Two hundred and fifty patients with schizophrenia who were followed up in the psychiatry clinic, and 400 age- and sex-matched non schizophrenia controls were included. Standart ECGs and high intercostal ECGs with V1 and V2 derivation above two intercostal intervals were taken.
Results: In schizophrenia patients, Type 1 Brugada syndrome was not observed, Type 2 Brugada was identified in one subject and Type 3 Brugada was observed in two patients. In the control group, Type 2 Brugada pattern was identified in one subject and again one control had Type 3 Brugada pattern(p=0.320). The fragmented QRS (fQRS) incidence, QRS duration and corrected QT were observed to be higher in the schizophrenia group compared to the control group (p=0.001, p=0.003, p<0.001, respectively).
Conclusions:There is no increased prevalence of Brugada-ECG pattern in patients with schizophrenia. Importantly, the prevelance of fQRS was significantly higher in patients with schizophrenia compared to the control group. Fqrs can be used to estimate the frequency of cardiovascular events in patients with schizophrenia.

Anahtar Kelimeler

schizophrenia, brugada, fragmented qrs

Kaynakça

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