İrritabıl Barsak Sendromunda Otonomik Fonksiyon Değerlenirmede Yeni Bir Belirteç Olarak Kalp Hızı Toparlanma İndeksi

Abstract

AMAÇ: İrritabıl barsak sendromunda (IBS) otonomik fonksiyon değerlendirilmesi ile ilgili yapılan çalışmalarda sıklıkla kalp hızı değişkenliği indeksi kullanılmış ve çelişkili sonuçlar elde edilmiştir. Biz bu çalışmada kalp hızı toparlanma indeksini (KHTİ) bu hasta grubunda otonom fonksiyon değerlendirmesinde yeni bir belirteç olarak önerdik ve çalıştık YÖNTEM: Çalışmaya 35 adet IBS hastası ile yaş ve cinsiyet açısından eşitlenmiş 35 adet sağlıklı kontrol hastası dahil edildi. Bütün hastalara transtorasik ekokardiyografi ve modifiye Bruce protokolü ile egzersiz ekg testi (efor testi) uygulandı. KHTİ ölçümleri egzersiz testi ani şekilde sonlandırıldıktan sonraki 1. ve 2. Dakikalarda ölçülerek kayıt altına alındı. BULGULAR: IBS ve kontrol hasta grubu yaş, cinsiyet, hipertansiyon ve sigara içiciliği açısından karşılaştırıldığında birbirlerine benzerdi. Vücut kitle indeksi ölçümlerinde IBS grubu istatiksel anlamlı olarak daha düşük ölçülere sahipti (26±3 vs 28±5, p=0.028). KHTİ ölçümleri açısından iki grup arasında anlamlı fark saptanmadı (IBS; 34±11 vs Kontrol; 36±11, p=0.459). SONUÇ: KHTİ göz önüne alındığında, otonom fonksiyon bozukluğu İBS hastalarında primer fizyopatolojik sebep olmayabilir.

Keywords

• irritabıl barsak sendromu
• kalp hızı toparlanma indeksi
• otonomik disfonksiyon

Heart Rate Recovery Index as a Novel Indicator of Autonomic Status in Irritable Bowel Syndrome

Abstract

Objective: There are numerous studies with conflicting results using heart rate variability as a marker for parasympathetic dysfunction in irritable bowel syndrome. In this study we aim to investigate heart rate recovery as a new tool to document autonomic status in IBS patients. Methods: We enrolled 35 IBS patients and 35 healthy age and sex matched controls in the study. All patients underwent transthoracic echocardiography and exercise ecg test with modified bruce protocol. Heart rate recovery measurements were taken at first and second minute after abrupt cessation of exercise. Results: IBS and control group were similar with respect to age, sex, hypertension and smoking status except BMI which was lower in IBS group. (26±3 vs 28±5, p=0.028). HRR values did not differ statistically between groups (IBS;34±11 vs Control;36±11, p=0,459). Conclusions: Our results suggest that autonomic imbalance might not be the primary pathophysiological mechanism in IBS patients according to HRR index. Keywords: heart rate recovery index, irritable bowel syndrome, autonomic dysfunction

Keywords

• heart rate recovery index
• irritable bowel syndrome

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