Öz
Kaynakça
- Referans [1] Shortliffe LMD. Infection and Inflammation of Pediatric Genitourinary Tract. 10th Edition, In Philadelphia, Elsevier Saunders: Cambell-Walsh Urology, 2012. Referans [2] Lin R. Vesicoureteral reflux and urinary tract infection evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol. 2009;192:1197-1208
- Referans [3] Simões e Silva AC1, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol. 2013 Jun;169(3):477-92.
- Referans [4] Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007 Sep;59(3):251-87.
- Referans [5] Youxia Liu , Xinxin Ma , Jie Zheng , Junya Jia and Tiekun Yan. Effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular events and residual renal function in dialysis patients: a meta-analysis of randomised controlled trials. BMC Nephrology (2017) 18:206 DOI 10.1186/s12882-017-0605-7
- Referans [6] Lama G, Salsano M E, Pedulla M, Grassia C, Ruocco G. Angiotensin converting enzyme inhibitors and reflux nephropathy: 2-year follow-up. Pediatr. Nephrol(Berlin, Germany). - December 1, 1997; 11 (6); 714-8
- Referans [7] Kitao T, Kimata T, Yamanouchi S, Kato S, Tsuji S, Kaneko K. Urinary Biomarkers for Screening for Renal Scarring in Children with Febrile Urinary Tract Infection: Pilot Study. J Urol. 2015 Sep;194(3):766-71. doi: 10.1016/j.juro.2015.04.091. Epub 2015 Apr 29.
- Referans [8] Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension. 1998 Sep;32(3):387-92.
- Referans [9] Yamada M, Ueda M, Naruko T, Tanabe S, Han YS, Ikura Y, Ogami M, Takai S, Miyazaki M. Mast cell chymase expression and mast cell phenotypes in human rejected kidneys. Kidney Int. 2001 Apr;59(4):1374-81.
- Referans [10] Li Y, Liu FY, Peng YM, Li J, Chen J. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis. Med Hypotheses. 2007;69(1):99-103. Epub 2007 Jan 25.
- Referans [11] Wu Y1, Liu Z, Hu W, Li L. Mast cell infiltration associated with tubulointerstitial fibrosis in chronic Aristolochic Acid Nephropathy. Hum Exp Toxicol. 2005 Feb;24(2):41-7.
- Referans [12] Dai H, Korthuis RJ. Mast Cell Proteases and Inflammation. Drug Discov Today Dis Models. 2011 Spring;8(1):47-55.
- Referans [13] Columbo M, Horowitz EM, Botana LM, McGlashan DW Jr, Bochner BS, Gillis S, Zsebo KM, Galli SJ, Lichtenstein LM. The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol 1992;149: 599 –608.
- Referans [14] Kondo S, Kagami S, Kido H, Strutz F, Müller GA, Kuroda Y. Role of mast cell tryptase in renal interstitial fibrosis. J Am Soc Nephrol. 2001 Aug;12(8):1668-76.
- Referans [15] Singal AK, Bajpai M, Dinda AK. Blockade of Renin-Angiotensin system blunts the fibrotic response in experimental acute pyelonephritis. J Indian Assoc Pediatr Surg/ Jan-Mar 2005/vol 10/Issue 1:20-24
- Referans [16] Abareshi A, Norouzi F, Asgharzadeh F, Beheshti F, Hosseini M, Farzadnia M, Khazaei M. Effect of Angiotensin-converting Enzyme Inhibitor on Cardiac Fibrosis and Oxidative Stress Status in Lipopolysaccharide-induced Inflammation Model in Rats.Int J Prev Med. 2017 Sep 6;8:69. doi: 10.4103/ijpvm.IJPVM_322_16. eCollection 2017.
- Referans [17] Hrenák J, Arendášová K, Rajkovičová R, Aziriová S, Repová K, Krajčírovičová K, Celec P, Kamodyová N, Bárta A, Adamcová M, Paulis L, Simko F.Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol Res. 2013;62 Suppl 1:S181-9.
- Referans [18] Kostan W Reisinger, Jacco J de Haan, and Marc H Schreinemacher. Word of caution before implementing ketotifen for gastrointestinal transit improvement. World J Gastroenterol. 2013 Jul 21; 19(27): 4445–4446. Published online 2013 Jul 21. doi: 10.3748/wjg.v19.i27.4445
- Referans [19] Yukselen V, Karaoglu AO, Ozutemiz O, Yenisey C, Tuncyurek M. Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus. Pediatr Surg Int. 2004 Jun;20(6):429-33. Epub 2004 Apr 24.
- Referans [20] Emamghorashi F, Owji SM, Motamedifar M. Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat. Adv Urol. 2011; 2011:489496.
- Referans [21] Roupakias S, Sinopidis X, Karatza A, Varvarigou A. Predictive risk factors in childhood urinary tract infection, vesicoureteral reflux, and renal scarring management. Clin Pediatr (Phila). 2014 Oct;53(12):1119-33.
- Referans [22] Smith EA. Pyelonephritis, renal scarring, and reflux nephropathy: a pediatric urologist's perspective. Pediatr Radiol. 2008 Jan;38 Suppl 1:S76-82.
- Referans [23] Roberts IS, Brenchley PE. Mast cells: the forgotten cells of renal fibrosis. J Clin Pathol. 2000 Nov;53(11):858-62.
Öz
Amaç: Hipertansiyon ve diabete
bağlı nefropati gelişiminden artmış Angiotensin II (Ang II) düzeyleri sorumlu
tutulmaktadır. Bunun yanı sıra Ang II blokajı ile renal fibrozis gelişiminin
önlenebilirliği bilinen bir antitedir. Böbrek
dokusunun doğal bir elemanı olmamasına rağmen fibrosis nedeniyle incelenen
spesmenlerde artmış mast hücre yoğunluğu dikkati çekmiş ve bu hücrelerden
salınan fibrotik ajanların sürece katkıda bulunabileceği düşünülmüştür. Bu nedenle Ang II düzeylerinin bir anjiotensin
converting enzim (ACE) inhibitörü olan kaptopril ile düşürülmesi ve yine bir mast
hücre stabilizatörü olan ketotifenin kullanımı ile pyelonefrrite bağlı böbrek
skarı gelişiminin önlenebilirliği hakkında deneysel çalışma planlandı.
Materyal ve
Metod: Elli
rat beş eşit gruba bölündü. Grup A’da renal kortekse SF enjeksiyonu yapıldı.
Grup B’de renal kortekse 107 E. coli enjeksiyonu ile akut
pyelonefrit oluşturuldu. Grup C’de E. coli enjeksiyonu ile beraber antibiyotik
tedavisi, Grup D’de E. coli enjeksiyonu ile antibiyotik ve kaptopril uygulaması,
Grup E’de E. coli enjeksiyonu ile antibiyotik ve ketotifen verildi. Kronik süreci
temsil etmek amacı ile ratlar altı hafta sonra sakrifiye edildi, karşı böbrek
de patolojik inceleme ve istatistiksel değerlendirmeye alındı.
Sonuçlar: Grup B’de inflamatuar
skorların A grubuna (sham) göre istatistiksel olarak anlamlı arttığı görüldü
(p= 0.001). Skar gelişimini azaltan tek faktörün ise kaptopril ya da ketotifen
tedavisi olduğu görüldü (p= 0.007). Ancak kaptopril ya da ketotifen
tedavilerinin; skar gelişiminin
önlenmesi açısından birbirlerine üstünlükleri saptanmadı (p>0.05).
Tartışma: Ratlarda pyelonefrit
modelinde kaptopril veya ketotifen tedavisinin renal fibrozis gelişimini
önleyici etkisi mevcuttur. Çalışmamızın renal skar gelişimin önlenmesinde
klinik çalışmalar için katkı sağlayabileceği düşüncesindeyiz.
Anahtar Kelimeler
Angiotensin-converting enzyme inhibitors captopril ketotifen
Kaynakça
- Referans [1] Shortliffe LMD. Infection and Inflammation of Pediatric Genitourinary Tract. 10th Edition, In Philadelphia, Elsevier Saunders: Cambell-Walsh Urology, 2012. Referans [2] Lin R. Vesicoureteral reflux and urinary tract infection evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol. 2009;192:1197-1208
- Referans [3] Simões e Silva AC1, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol. 2013 Jun;169(3):477-92.
- Referans [4] Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007 Sep;59(3):251-87.
- Referans [5] Youxia Liu , Xinxin Ma , Jie Zheng , Junya Jia and Tiekun Yan. Effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular events and residual renal function in dialysis patients: a meta-analysis of randomised controlled trials. BMC Nephrology (2017) 18:206 DOI 10.1186/s12882-017-0605-7
- Referans [6] Lama G, Salsano M E, Pedulla M, Grassia C, Ruocco G. Angiotensin converting enzyme inhibitors and reflux nephropathy: 2-year follow-up. Pediatr. Nephrol(Berlin, Germany). - December 1, 1997; 11 (6); 714-8
- Referans [7] Kitao T, Kimata T, Yamanouchi S, Kato S, Tsuji S, Kaneko K. Urinary Biomarkers for Screening for Renal Scarring in Children with Febrile Urinary Tract Infection: Pilot Study. J Urol. 2015 Sep;194(3):766-71. doi: 10.1016/j.juro.2015.04.091. Epub 2015 Apr 29.
- Referans [8] Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension. 1998 Sep;32(3):387-92.
- Referans [9] Yamada M, Ueda M, Naruko T, Tanabe S, Han YS, Ikura Y, Ogami M, Takai S, Miyazaki M. Mast cell chymase expression and mast cell phenotypes in human rejected kidneys. Kidney Int. 2001 Apr;59(4):1374-81.
- Referans [10] Li Y, Liu FY, Peng YM, Li J, Chen J. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis. Med Hypotheses. 2007;69(1):99-103. Epub 2007 Jan 25.
- Referans [11] Wu Y1, Liu Z, Hu W, Li L. Mast cell infiltration associated with tubulointerstitial fibrosis in chronic Aristolochic Acid Nephropathy. Hum Exp Toxicol. 2005 Feb;24(2):41-7.
- Referans [12] Dai H, Korthuis RJ. Mast Cell Proteases and Inflammation. Drug Discov Today Dis Models. 2011 Spring;8(1):47-55.
- Referans [13] Columbo M, Horowitz EM, Botana LM, McGlashan DW Jr, Bochner BS, Gillis S, Zsebo KM, Galli SJ, Lichtenstein LM. The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol 1992;149: 599 –608.
- Referans [14] Kondo S, Kagami S, Kido H, Strutz F, Müller GA, Kuroda Y. Role of mast cell tryptase in renal interstitial fibrosis. J Am Soc Nephrol. 2001 Aug;12(8):1668-76.
- Referans [15] Singal AK, Bajpai M, Dinda AK. Blockade of Renin-Angiotensin system blunts the fibrotic response in experimental acute pyelonephritis. J Indian Assoc Pediatr Surg/ Jan-Mar 2005/vol 10/Issue 1:20-24
- Referans [16] Abareshi A, Norouzi F, Asgharzadeh F, Beheshti F, Hosseini M, Farzadnia M, Khazaei M. Effect of Angiotensin-converting Enzyme Inhibitor on Cardiac Fibrosis and Oxidative Stress Status in Lipopolysaccharide-induced Inflammation Model in Rats.Int J Prev Med. 2017 Sep 6;8:69. doi: 10.4103/ijpvm.IJPVM_322_16. eCollection 2017.
- Referans [17] Hrenák J, Arendášová K, Rajkovičová R, Aziriová S, Repová K, Krajčírovičová K, Celec P, Kamodyová N, Bárta A, Adamcová M, Paulis L, Simko F.Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol Res. 2013;62 Suppl 1:S181-9.
- Referans [18] Kostan W Reisinger, Jacco J de Haan, and Marc H Schreinemacher. Word of caution before implementing ketotifen for gastrointestinal transit improvement. World J Gastroenterol. 2013 Jul 21; 19(27): 4445–4446. Published online 2013 Jul 21. doi: 10.3748/wjg.v19.i27.4445
- Referans [19] Yukselen V, Karaoglu AO, Ozutemiz O, Yenisey C, Tuncyurek M. Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus. Pediatr Surg Int. 2004 Jun;20(6):429-33. Epub 2004 Apr 24.
- Referans [20] Emamghorashi F, Owji SM, Motamedifar M. Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat. Adv Urol. 2011; 2011:489496.
- Referans [21] Roupakias S, Sinopidis X, Karatza A, Varvarigou A. Predictive risk factors in childhood urinary tract infection, vesicoureteral reflux, and renal scarring management. Clin Pediatr (Phila). 2014 Oct;53(12):1119-33.
- Referans [22] Smith EA. Pyelonephritis, renal scarring, and reflux nephropathy: a pediatric urologist's perspective. Pediatr Radiol. 2008 Jan;38 Suppl 1:S76-82.
- Referans [23] Roberts IS, Brenchley PE. Mast cells: the forgotten cells of renal fibrosis. J Clin Pathol. 2000 Nov;53(11):858-62.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | ORIGINAL ARTICLES |
| Yazarlar | |
| Yayımlanma Tarihi | 23 Aralık 2019 |
| Gönderilme Tarihi | 16 Temmuz 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 13 Sayı: 6 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.