Objective: The aim of this study was to assess thyroid function and lesions after radiotherapy to the head and neck region in children with Hodgkin lymphoma (HL) or central nervous system (CNS) tumors.
Material and Methods: The study included children diagnosed with HL or CNS tumors who were in complete remission at least one year after completion of chemotherapy (CT) and who had all received radiotherapy (RT) to the head and/or neck. All patients were requested to undergo thyroid function tests and thyroid ultrasonography (USG).
Results: A total of 37 patients were included. The mean age was 13.7±3.8 years. The mean follow-up time was 5.09±2.5 years. All patients had CT and RT. Seven (18.9%) patients had subclinical hypothyroidism, and 7 (18.9%) had thyroid USG abnormalities. None of the patients had thyroid malignancy. Age under 10 years at diagnosis, follow-up time of 3 years or more, and an RT dose of 25 Gy or more were found as effective factors for subclinical hypothyroidism development. Only an RT dose of 25 Gy or more was found to be related to thyroid USG abnormalities.
Conclusion: Thyroid function tests and thyroid imaging should be routinely examined in any patient who has been treated for cancer to evaluate thyroid dysfunction regardless of clinical findings and the follow-up of these patients should be lifelong.
Amaç: Bu çalışmanın amacı Hodgkin lenfoma (HL) veya merkezi sinir sistemi (SSS) tümörlü çocuklarda baş ve boyun bölgesine uygulanan radyoterapi sonrası tiroid fonksiyonunu ve lezyonları değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya HL veya SSS tümörü tanısı alan, kemoterapi (KT) ve baş boyun bölgesine radyoterapi (RT) tamamlanmasından en az bir yıl sonra tam remisyonda olan çocuklar dahil edildi. Tüm hastalardan tiroid fonksiyon testleri ve tiroid ultrasonografisi (USG) istendi.
Bulgular: Çalışmaya toplam 37 hasta dahil edildi. Yaş ortalaması 13.7±3.8’di. Ortalama takip süresi 5.09±2.5 yıldı. Tüm hastalarda BT ve RT mevcuttu. Yedi (%18.9) hastada subklinik hipotiroidi, 7 (%18.9) hastada tiroid USG anormalliği mevcuttu. Hastaların hiçbirinde tiroid malignitesi yoktu. Tanı anında 10 yaşın altında olmak, takip süresinin 3 yıl ve üzerinde olması, RT dozunun 25 Gy veya daha fazla olması subklinik hipotiroidizm gelişimi için etkili faktörler olarak bulundu. Sadece RT dozu 25 Gy veya daha fazlasının tiroid USG anormallikleri ile ilişkili olduğu saptandı.
Sonuç: Kanser tedavisi almış her hastada tiroid fonksiyon bozukluğunu değerlendirmek için klinik bulgulara bakılmaksızın tiroid fonksiyon testleri ve tiroid görüntülemesi rutin olarak incelenmeli ve bu hastaların takipleri ömür boyu yapılmalıdır.
Primary Language | English |
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Subjects | Internal Diseases |
Journal Section | ORIGINAL ARTICLES |
Authors | |
Early Pub Date | April 25, 2024 |
Publication Date | July 22, 2024 |
Submission Date | January 17, 2024 |
Acceptance Date | March 14, 2024 |
Published in Issue | Year 2024 Volume: 18 Issue: 4 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 7 articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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