D vitamini ve Tip 2 diyabet

Year 2016, , 167 - 177, 28.12.2016

Arda Karagöl Nazlı Atak

https://doi.org/10.20518/tjph.288397

Abstract

Bu çalışmanın amacı, tip 2 diyabet ile D vitamini
yetersizliği arasındaki olası ilişkinin değerlendirilmesidir. Tip 2 diyabet
(T2D) morbidite ve mortalitesi giderek artmaktadır. T2D ve komplikasyonlarının
tedavisinde ilerleme kaydedilmesine rağmen, hastalık yükünün giderek artması,
korunmada yeni yaklaşımların gerekliliğini ortaya koymaktadır. Ekolojik
kanıtlar, D vitamini yetersizliğinin belirgin olduğu az güneş alan bölgelerde,
diyabet sıklığının arttığını göstermiştir. D vitamini son zamanlarda T2D’in
etiyopatogenezi ve önlenmesinde giderek artan bir şekilde gündeme gelmektedir.
Yetersizliğinin T2D riskini arttırdığı belirtilmekle birlikte, nedensel ilişki
ile ilgili kanıtlar, yeterli sayıda yüksek kalitede randomize kontrollü
çalışmalar bulunmadığı için sınırlıdır. Korunmada yaşam biçimi ve
davranışlarının değiştirilmesi yüksek riskli bireylerde önemli bir yaklaşımdır.
Ek olarak 25(OH)D3 düzeyinin arttırılması da, T2D’in önlenmesi ve tedavisinde
umut vadeden bir yaklaşım olabilir. Bu konuda bazı önemli sonuçlara ulaşılmış
olsa da ileriye dönük geniş kapsamlı çalışmalara gereksinim bulunmaktadır.

Keywords

D vitamini, Tip 2 diyabet, D vitamini eksikliği, D vitamini yetersizliği

References

• Khan H, Kunutsor S, Franco OH, Chowdhury R. Vitamin D, Type 2 Diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies. Proceed Nutr Soc 2013; 72(1):89-97.
• 2. Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006;116(8):2062-2072.
• 3. Holick MF, Garabedian M. Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of the mineral metabolism. 6th ed. American Society for Bone and Mineral Research, Washington 2006, pp. 129-137.
• 4. Bellan M, Guzalloni G, Rinaldi M et al. Altered glucose metabolsim rather than naive type 2 diabetes mellitus (T2D) is related to vitamin D status in severe obesity. Card Diabetol 2014;13(57):1-10.
• 5. Lim S, Kim MJ, Choi CS et al. Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr 2013;97(3):524-530.
• 6. Rosen CJ, Adams JS, Bikle DD et al. The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocr Rev 2012;33(3):456-492.
• 7. Lim S, Shin H, Kim MJ et al. Vitamin D in adequacy is associated with significant coronary artery stenosis in a community-based elderly cohort: the Korean Longitudinal Study on Health and Aging. J Clin Endocrinol Metab 2012;97(1):169-178.
• 8. Palomer X, Gonzales-Clemente JM, Blanco Vaca F, Mauricio D. Role of Vitamin D in the pathogenezis of type 2 diabetes mellitus. Diab Obes Metab 2008;10(3):185-197.
• 9. Mezza T, Muscogiuri Sorice GP, Prioletta A et al. Vitamin D Deficiency: A New Risk Factor For Type 2 Diabetes? Ann Nutr Met 2012;61(4):337-348.
• 10. Alvarez JA, Ashraf A. Role of Vitamin D in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis. Int J Endocrinol 2010(2010); p 1-18.
• Lee BK, Park S, Kim Y. Age- and gender-specific associations between low serum 25-hydroxyvitamin D level and type 2 diabetes in the Korean general population: analysis of 2008-2009; Korean National Health and Nutrition Examination Survey data. Asia Pac J Clin Nutr 2012;21(4):536-546.
• 12. Stivelman E, Retnakaran R. Role of Vitamin D in the Pathophysiology and Treatment of Type 2 Diabetes. Curr Diab Rev 2012;8(1):42-47.
• 13. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: A Systematic Review. Eur J Clin Nutr 2011;65(9):1005-1015
• 14. Cangoz S, Chang Y-Y, Chempakaseril SJ et al. Vitamin D and type 2 diabetes mellitus. J Clin Pharm Therap 2013;38(2):81-84.
• 15. Gedik O, Akalın S. Effects of Vitamin D deficiency and repletion on insülin and glucagon secretion in man. Diabetologia 1986;29(2):142-145.
• 16. Pittas AG, Lau J, Hu F, Dawson-Hughes B. The role of Vitamin D and Calcium in type 2 diabetes. A systematic Review and Meta-Analysis. J Clin Endocrinol Metab 2007;92(6):2017-2029.
• 17. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010;95(2):471-478.
• 18. Holick MF. Vitamin D deficiency. New Engl J Med 2007;357(3):266-281.
• 19. George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insülin resistance: a systematic review and meta- analysis. Diab Med 2012;29(8):e142-e150.
• 20. Segal S, Lloyd S, Sherman N, Sussman K, Draznin B. Postprandial changes in cytosolic free calcium and glucose uptake in adipocytes in obesity and non-insulin dependent diabetes mellitus. Horm Res 1990;34:39-44.
• Ohno Y, Suzuki H, Yamakawa H, Nakamura M, Otsuka K, Saruta T. Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism. J Hypertens 1993;11(4):421-426.
• 22. Zemel MB. Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insülin resistance and hypertension. Mol Cell Biochem 1998;188(1-2):129-136.
• 23. Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr 2008;87(suppl):1080S-1086S.
• 24. Grineva EN, Karonova T, Micheeva E, Belyaeva O, Nikitina IL. Aging 2013;5(7):575-581.
• 25. American Diabetes Association. Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus: follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26(11):3160-3167.
• 26. Global Report on Diabetes 2016. Erişim adresi: http://www.who.int/diabetes/global-report/en/ Erişim tarihi:22.10.2016.
• 27. Global status report on noncommunicable diseases. Erişim adresi: http://www.who.int/nmh/publications/nc-status-report-2014/en/ Erişim tarihi: 25.02.2016.
• 28. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Geneva, World Health Organization, 1999 (WHO/NCD/NCS/99.2).
• 29. Satman I, Ömer B, Tütüncü Y et al. Twelve Year Trends in the Prevalance and risk factors of Diabetes and prediabetes in Turkish adulta. Eur J Epidemiology 2013:28(1):169-180.
• 30. Satman I, Yılmaz T, Sengul A et al. The TURDEP Group: Population based study of diabetes and risk characteristics in Turkey: results of the Turkish diabetes epidemiology study (TURDEP). Diabetes Care 2002;25(9):1551-1556.
• Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. The Endocrine Society’s Clinical Guidelines. © The Endocrine Society, 2011.
• 32. Husemoen LLN, Thuesen BH, Fenger M et al. Serum 25(OH)D and Type 2 Diabetes Association in a General population. A prospective study. Diabetes Care 2012;35(8):1695-1700.
• 33. Al Tımim DJ, Ardawan FA. Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control. J Clin Diag Research 2013;7(12):2686-2688.
• 34. Boucher BJ, Mannan N, Noonan K et al. Glucose intolerance and impairment of insülin secretion in relation to vitamin D deficiency in East London Asians. Diabetologia 1995;38(10):1239-1245.
• 35. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89(5):552-572.
• 36. Boucher BJ. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’. Br J Nutr 1998;79(4):315-327.
• 37. Alvarez JA, Ashraf AP, Hunter GR, Gower BA. Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. Am J Clin Nutr 2010;92(6):1344-1349.
• 38. Scragg R, Sowers M, Bell C. Third National Health and Nutrition Examination Survey. Serum 25 hydroxyvitamin D, Diabetes and Ethnicity in the third National Health and Nutrition Examination Survey. Diabetes Care 2004;27(12):2813-2818.
• 39. Isaia G, Giorgino R, Adami S. High prevalance of hypovitaminosis D in female type 2 diabetic population. Diabetes Care 2001;24(8):1496.
• 40. Targher G, Bertollini L, Padovani et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol (Oxf) 2006;65(5):593-597.
• Borissova AM, Tankova T, Kirilov G et al. The effect of vitamin D3 on insülin secretion and peripheral insülin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003;57: 258-261.
• 42. Chiu KC, Chuang LM, Yoon C. The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet 2001;2(2):1-8.
• 43. Scragg R, Sowers M, Bell C. Serum 25 hydroxyvitamin D, diabetes and ethnicity in the third National Health and Nutrition Examination Survey. Diabetes Care 2004;27(12):2813-2818.
• 44. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 2011;65(9):1005-1015.
• 45. Araceli Muñoz-Garach, Mercedes Clemente-Postigo, Diego Fernandez-García, Fernando Cardona-Diaz, Manuel Macias-Gonzalez & Francisco Tinahones-Madueño. Relationship between serum 25-hydroxivitamin D3 and adipose tissue vitamin D receptor gene expression with obesity and type 2 diabetes. Endocrine Abstracts (2015) DOI: http://dx.doi.org/10.1210/jc.2014-3016
• 46. Scragg R, Holdaway I, Singh V et al. Serum 25-hydroxyvitamin D3 levels decreased in IGT and diabetes. Diabetes Res Clin Pract 1995;27(3):181-188.
• 47. Knekt P, Laaksonen M, Mattila C et al. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology 2008;19(5):666-671.
• 48. Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia 2012;55(6):1668-1678.
• 49. Dalgard C, Skaalum Peterson M, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism in septuagenarians. Diabetes Care 2011;34(6):1284-1288
• 50. Baynes KCR, Boucher BJ, Feskens EJM et al. Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 1997;40(3):344-347.
• Pittas A, Nelson J, Mitri J, Hilmann W, Garganta C, Nathan D et al. Plasma 25- hydroxy vitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Programme. Diabetes Care 2012;35(3):565-573.
• 52. Kayaniyil S, Retnakaran R, Haris SB et al. Prospective associations of vitamin D with beta-cell function and glycemia: the PROspective Metabolism and ISlet cell evaluation (PROMISE) cohort study. Diabetes 2011;60(11):2947-2953.
• 53. Schöttker B, Herder C, Rothenbacher D, Perna L, Müler H, Brenner H. Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults. Eur J Epidemiol 2013;28(3):267-275.
• 54. Afzal S, Bojesen SE, Nordestgaard BG. Low 25-Hydroxyvitamin D and Risk of Type 2 Diabetes: A prospective Cohort Study and Metaanalysis. Clin Chem 2013;59(2):381-391.
• 55. Forouhi NG, Rickard Z Ye AP, Khaw KT, Luben R, Langenberg C, Wareham NJ. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the european Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia 2012;55(8):2173-2182.
• 56. Pittas AG, Sun Q, Manson JE, Dawson-Hughes B, Hu FB. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care 2010;33(9):2021-2023.
• 57. Giovannucci E.Can vitamin D reduce total mortality? Arch Intern Med 2007;167(16):1709-1710.
• 58. van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab 2011;25(4):671-80.
• 59. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48(7):1247-1257.