BibTex RIS Kaynak Göster

Bağırsak mikrobiyotası ve sağlık

Yıl 2018, , 58 - 73, 30.04.2018
https://doi.org/10.20518/tjph.458203

Öz

Her organın diğer adı flora olan mikrobiyotası bulunmaktadır. Mikrobiyota denince akla ilk olarak gastrointestinal sistem gelmektedir. İntestinal mikrobiyotadaki mikroplar, insan fizyolojisinin
biçimlendirilmesi, sürdürülmesi ve homeostazda aktif olarak görev almaktadır. İntestinal mikrobiyota, en fazla sayıda bakteri ve sinir hücresi bulundurduğu için, ikinci beyin olarak adlandırılmaktadır. İnutero geliştiği düşünülmekte olup, çeşitli çevresel faktörlerden etkilenmektedir. İmmun sistemin fonksiyonunda ve metabolizmanın regülasyonunda önemli rol oynamaktadır. Bu bağlamda, kanserler, tip 2 diyabet, Alzheimer gibi kronik hastalıklarla ilişkilidir. Bazı hastalıkların ortaya çıkmasında, disbiyozun rol oynadığı düşünülmektedir. Yapılacak bazı müdahalelerle hastalıkların önlenmesi mümkün olsa da konu ile ilgili ileri çalışmalara gerek bulunmaktadır.

Kaynakça

  • 1.Pelzer E, et al. Review: Maternal health and the placental microbiome. Placenta 2017;54:30-37
  • 2.Yang N J, Chiu I M. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol 2017;429(5):587-605
  • 3.Sonnenburg J, Sonnenburg E. The Good Gut Gut Feelings–the "Second Brain" in Our Gastrointestinal Systems [Excerpt]. New York:Penguin Books 2015. Available at: https://www.scientificamerican.com/articl e/gut-feelings-the-second-brain-in-ourgastrointestinal-systems-excerpt/
  • 4.Sommer F, Bäckhed F. Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. BioEssays 2016;38(5):455464
  • 5.Falony G, et al. Population-level analysis of gut microbiome variation. Science 2016;352(6285):560-564
  • 6.Liu S. The Development of Our Organ of Other Kinds—The Gut Microbiota. Front Microbiol 2016;7(2107):
  • 7.Sun J, Kato I. Gut microbiota, inflammation and colorectal cancer. Genes & Diseases 2016;3(2):130-143
  • 8.Pagliari D, et al. The Interactions between Innate Immunity and Microbiota in Gastrointestinal Diseases. J Immunol Res 2015;2015:1-3
  • 9.Martin F-P J, Montoliu I, Kussmann M. Metabonomics of ageing – Towards understanding metabolism of a long and healthy life. Mech Ageing Dev 2017;165:171179
  • 10.Herrema H, Ijzerman R G, Nieuwdorp M. Emerging role of intestinal microbiota and microbial metabolites in metabolic control. Diabetologia 2016;60(4):613-617
  • 11.von Martels J Z H, et al. The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut. Anaerobe 2017;44:3-12
  • 12.Grigg J B, Sonnenberg G F. HostMicrobiota Interactions Shape Local and Systemic Inflammatory Diseases. J Immunol 2017;198(2):564-571
  • 13.Nagpal R, et al. Sensitive Quantitative Analysis of the Meconium Bacterial Microbiota in Healthy Term Infants Born Vaginally or by Cesarean Section. Front Microbiol 2016;7:
  • 14.Mayer E A, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest 2015;125(3):926-938
  • 15.Ochoa-Repáraz J, Kasper L H. The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders? Curr Obes Rep 2016;5(1):51-64
  • 16.Yao J, Rock C O. How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics. J Biol Chem 2015; 290(10): 5940-5946
  • 17.Wasielewski H, Alcock J, Aktipis A. Resource conflict and cooperation between human host and gut microbiota: implications for nutrition and health. Ann N Y Acad Sci 2016;1372(1):20-28
  • 18.Gregor, M.F. and G.S. Hotamisligil, Inflammatory mechanisms in obesity. Annu Rev Immunol, 2011. 29: p. 415-45.
  • 19.de Cossío L F, et al. Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome. Brain, Behav Immun 2017;64:33-49
  • 20.Liu J, et al. Inside Out: HIV, the Gut Microbiome, and the Mucosal Immune System. J Immunol 2017;198(2):605-614
  • 21.Viramontes Hörner D, Avery A, Stow R. The Effects of Probiotics and Symbiotics on Risk Factors for Hepatic Encephalopathy. J Clin Gastroenterol 2017;51(4):312-323
  • 22.Palacios T, et al. The effect of a novel probiotic on metabolic biomarkers in adults with prediabetes and recently diagnosed type 2 diabetes mellitus: study protocol for a randomized controlled trial. Trials 2017;18(1):
  • 23.Patel S, Goyal A. The current trends and future perspectives of prebiotics research: a review. 3 Biotech 2012;2(2):115-125
  • 24.Lin L, Zhang J. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol 2017;18(2):
  • 25.Coondoo A. Cytokines in dermatology - A basic overview. Indian J Dermatol 2011;56(4):368
  • 26.Berbers R-M, et al. Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences. Trends Immunol 2017;38(3):206-216
  • 27.Hov J R, Kummen M. Intestinal microbiota in primary sclerosing cholangitis. Curr Opin Gastroenterol 2017;33(2):85-92
  • 28.Salman T., V.U., Yıldız İ. Küçükzeybek Y., Alacacıoğlu A. Mikrobiyota ve Kanser. Acta Oncol Turcica 2015;48(2):73-78
  • 29.Kennedy P J, et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology 2017;112:399412
  • 30.Ogawa S, et al. Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis. J Clin Psychiatry 2014;75(9):906–915
  • 31.Clark A, Mach N. Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response. Front Immunol 2016;7(627):
  • 32.Demirci H., U.A. Fekal Transplantasyon Nasıl ve Kime Uygulanmalı. Güncel Gastroenterol 2014;18(4):444-447

Intestinal microbiota and health

Yıl 2018, , 58 - 73, 30.04.2018
https://doi.org/10.20518/tjph.458203

Öz

Each organ has a unique microbiota, formerly known as its flora. In discussions around microbiota, intestinal microbiota comes to mind first. Microbes in the intestinal microbiota are essential for shaping and maintaining human physiology, and play an active role in hemostasis. As the gastrointestinal system holds a lot of bacteria and neurons, it is often called the second brain. The gastrointestinal microbiota is formed in utero and is influenced by various environmental factors. It influences the functioning of the immune system, as well as affecting the regulation of the metabolism. In this context, the gastrointestinal microbiota is implicated in some types of cancer, type 2 diabetes and Alzheimer’s disease. It is thought that dysbiosis plays a part in the occurence of certain diseases. Therefore, it might be possible to prevent some diseases via the introduction of certain interventions. Further studies are needed in this field. Key

Kaynakça

  • 1.Pelzer E, et al. Review: Maternal health and the placental microbiome. Placenta 2017;54:30-37
  • 2.Yang N J, Chiu I M. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol 2017;429(5):587-605
  • 3.Sonnenburg J, Sonnenburg E. The Good Gut Gut Feelings–the "Second Brain" in Our Gastrointestinal Systems [Excerpt]. New York:Penguin Books 2015. Available at: https://www.scientificamerican.com/articl e/gut-feelings-the-second-brain-in-ourgastrointestinal-systems-excerpt/
  • 4.Sommer F, Bäckhed F. Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. BioEssays 2016;38(5):455464
  • 5.Falony G, et al. Population-level analysis of gut microbiome variation. Science 2016;352(6285):560-564
  • 6.Liu S. The Development of Our Organ of Other Kinds—The Gut Microbiota. Front Microbiol 2016;7(2107):
  • 7.Sun J, Kato I. Gut microbiota, inflammation and colorectal cancer. Genes & Diseases 2016;3(2):130-143
  • 8.Pagliari D, et al. The Interactions between Innate Immunity and Microbiota in Gastrointestinal Diseases. J Immunol Res 2015;2015:1-3
  • 9.Martin F-P J, Montoliu I, Kussmann M. Metabonomics of ageing – Towards understanding metabolism of a long and healthy life. Mech Ageing Dev 2017;165:171179
  • 10.Herrema H, Ijzerman R G, Nieuwdorp M. Emerging role of intestinal microbiota and microbial metabolites in metabolic control. Diabetologia 2016;60(4):613-617
  • 11.von Martels J Z H, et al. The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut. Anaerobe 2017;44:3-12
  • 12.Grigg J B, Sonnenberg G F. HostMicrobiota Interactions Shape Local and Systemic Inflammatory Diseases. J Immunol 2017;198(2):564-571
  • 13.Nagpal R, et al. Sensitive Quantitative Analysis of the Meconium Bacterial Microbiota in Healthy Term Infants Born Vaginally or by Cesarean Section. Front Microbiol 2016;7:
  • 14.Mayer E A, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest 2015;125(3):926-938
  • 15.Ochoa-Repáraz J, Kasper L H. The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders? Curr Obes Rep 2016;5(1):51-64
  • 16.Yao J, Rock C O. How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics. J Biol Chem 2015; 290(10): 5940-5946
  • 17.Wasielewski H, Alcock J, Aktipis A. Resource conflict and cooperation between human host and gut microbiota: implications for nutrition and health. Ann N Y Acad Sci 2016;1372(1):20-28
  • 18.Gregor, M.F. and G.S. Hotamisligil, Inflammatory mechanisms in obesity. Annu Rev Immunol, 2011. 29: p. 415-45.
  • 19.de Cossío L F, et al. Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome. Brain, Behav Immun 2017;64:33-49
  • 20.Liu J, et al. Inside Out: HIV, the Gut Microbiome, and the Mucosal Immune System. J Immunol 2017;198(2):605-614
  • 21.Viramontes Hörner D, Avery A, Stow R. The Effects of Probiotics and Symbiotics on Risk Factors for Hepatic Encephalopathy. J Clin Gastroenterol 2017;51(4):312-323
  • 22.Palacios T, et al. The effect of a novel probiotic on metabolic biomarkers in adults with prediabetes and recently diagnosed type 2 diabetes mellitus: study protocol for a randomized controlled trial. Trials 2017;18(1):
  • 23.Patel S, Goyal A. The current trends and future perspectives of prebiotics research: a review. 3 Biotech 2012;2(2):115-125
  • 24.Lin L, Zhang J. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol 2017;18(2):
  • 25.Coondoo A. Cytokines in dermatology - A basic overview. Indian J Dermatol 2011;56(4):368
  • 26.Berbers R-M, et al. Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences. Trends Immunol 2017;38(3):206-216
  • 27.Hov J R, Kummen M. Intestinal microbiota in primary sclerosing cholangitis. Curr Opin Gastroenterol 2017;33(2):85-92
  • 28.Salman T., V.U., Yıldız İ. Küçükzeybek Y., Alacacıoğlu A. Mikrobiyota ve Kanser. Acta Oncol Turcica 2015;48(2):73-78
  • 29.Kennedy P J, et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology 2017;112:399412
  • 30.Ogawa S, et al. Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis. J Clin Psychiatry 2014;75(9):906–915
  • 31.Clark A, Mach N. Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response. Front Immunol 2016;7(627):
  • 32.Demirci H., U.A. Fekal Transplantasyon Nasıl ve Kime Uygulanmalı. Güncel Gastroenterol 2014;18(4):444-447
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Rapor
Yazarlar

Kamer Kalip

Nazlı Atak Bu kişi benim

Yayımlanma Tarihi 30 Nisan 2018
Gönderilme Tarihi 22 Temmuz 2017
Yayımlandığı Sayı Yıl 2018

Kaynak Göster

APA Kalip, K., & Atak, N. (2018). Bağırsak mikrobiyotası ve sağlık. Turkish Journal of Public Health, 16(1), 58-73. https://doi.org/10.20518/tjph.458203
AMA Kalip K, Atak N. Bağırsak mikrobiyotası ve sağlık. TJPH. Nisan 2018;16(1):58-73. doi:10.20518/tjph.458203
Chicago Kalip, Kamer, ve Nazlı Atak. “Bağırsak Mikrobiyotası Ve sağlık”. Turkish Journal of Public Health 16, sy. 1 (Nisan 2018): 58-73. https://doi.org/10.20518/tjph.458203.
EndNote Kalip K, Atak N (01 Nisan 2018) Bağırsak mikrobiyotası ve sağlık. Turkish Journal of Public Health 16 1 58–73.
IEEE K. Kalip ve N. Atak, “Bağırsak mikrobiyotası ve sağlık”, TJPH, c. 16, sy. 1, ss. 58–73, 2018, doi: 10.20518/tjph.458203.
ISNAD Kalip, Kamer - Atak, Nazlı. “Bağırsak Mikrobiyotası Ve sağlık”. Turkish Journal of Public Health 16/1 (Nisan 2018), 58-73. https://doi.org/10.20518/tjph.458203.
JAMA Kalip K, Atak N. Bağırsak mikrobiyotası ve sağlık. TJPH. 2018;16:58–73.
MLA Kalip, Kamer ve Nazlı Atak. “Bağırsak Mikrobiyotası Ve sağlık”. Turkish Journal of Public Health, c. 16, sy. 1, 2018, ss. 58-73, doi:10.20518/tjph.458203.
Vancouver Kalip K, Atak N. Bağırsak mikrobiyotası ve sağlık. TJPH. 2018;16(1):58-73.

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