What is the best animal model for leishmaniasis studies?

Yıl 2018, Cilt: 2 Sayı: 2, 28 - 31, 24.12.2018

Şerife Akküçük Özlem Makbule Kaya Mehmet Yaman

Öz

Leishmaniasis is a zoonotic disease which has
worldwide importance and is hard to control and treat. Researchers have not yet
developed a protective vaccine for humans in the light of current studies.
Various experimental animal models are being used since; i) Leishmania has
different species and vectors, ii) there are still many clinical, pathological
and immunological issues that have to be investigated, iii) new non-toxic
medical recipes to have maximum yield in a short time have to be investigated,
iv) protective vaccination have to be developed. Mouse, hamster, dog, rodent,
and non-human primates are among these animal models. None of them has the same
clinical features, pathogenesis and immunology with the disease in human.
However, rodents, dogs, and monkeys, which are the last host of the parasite,
are among the most preferred models in recent days. Considering the different
clinical forms of the disease, it is best to decide which Leishmania species to
work with which animal. This review is intended to guide the researchers in
choosing an appropriate animal model for leishmaniasis studies.

Anahtar Kelimeler

Leishmaniasis, animal models, Leishmania species

Kaynakça

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