İSONİAZİD VE BAZI AMİNO ASİTLERİN GEÇİŞ METALLERİ İLE OLUŞTURDUĞU ÜÇLÜ KOMPLEKSLERİN TAYİNİ

Yıl 2013, Cilt: 14 Sayı: 1, 1 - 14, 20.11.2016

Bilgiç Alkaya Serap Karaderi Gülbin Erdoğan

Öz

Bu çalışmada isoniazid ve iki aminoasitin bakır(II) ve çinko(II) metalleri ile oluşturduğu karışık kompleks oluşum dengeleri Irving Rossotti metodu ile potansiyometrik olarak tayin edildi. Üçlü komplekslerin stabilite sabitleri Irving Rossotti yöntemi ile 25±0.1 ºC de ve iyonik kuvvet (0.11M) NaClO4 ile sabit tutularak sulu çözeltide incelendi. 25 ºC de karışık ligand komplekslerin oluşum sabitleri;

Cu(II)-isoniazid-L-asparajin logK= 7.29; Zn(II)-isoniazid-L-asparajin logK= 4.09; Cu(II)-isoniazid-L-glutamik asit logK= 6.70; Zn(II)-isoniazid-L-glutamik asit logK= 6.30 olarak bulundu. Oluşan komplekslerin koşullu oluşum sabitleri pH’a bağlı olarak hesaplandı ve belirli bir pH bölgesinde koşullu oluşum sabitinin maksimum olduğu değerin deneysel olarak bulunan kararlılık sabiti ile uyum içinde olduğu gözlendi. Ayrıca karışık kompleksten türeyen türlerin bağıl bollukları oluşum sabitlerinden hesaplandı.

Anahtar Kelimeler

: İsoniazid, L-asparajin, L-glutamik asit, metal kompleks, potansiyometri, kararlılık sabiti

TERNARY COMPLEX FORMATION OF ISONIAZID WITH SOME TRANSITION METALS AND AMINO ACIDS

Öz

In this article mixed ligand complex formation equilibria of copper(II) and zinc(II) with isoniazid and two amino acids have been determined by potentiometric titration method, involving the use of Irving Rossotti procedure. The formation constants of mixed ligand complexes have been found to be Cu(II)-isoniazid-L-asparagine logK= 7.29; Zn(II)- isoniazid-L-asparagine logK= 4.09 and Cu(II)-isoniazid-L-glutamic acid logK= 6.70; Zn(II)- isoniazid-L-glutamic acid logK= 6.30, at 25.0±0.1° C and I= 0.11 mol dm-3 ionic strength (NaCIO4) in aqueous solution. The maximum values of the conditional formation constants were found to be in accordance with the mixed-ligand complex formation constants in a given pH region. In addition, the mole fractions of different species from mixed complexes were calculated by means of formation constants.

Anahtar Kelimeler

Isoniazid, L-asparagine, L-glutamic acid, metal complex, satibility constant

Kaynakça

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