ANTIOXIDANT RESPONSE IN BRAIN TISSUSE OF CAPOETA UMBLA EXPOSED TO CHLORPYRIFOS

Yıl 2024, Cilt: 11 Sayı: 4, 1149 - 1153, 12.10.2024

Mehmet Reşit Taysı

https://doi.org/10.30910/turkjans.1546985

Öz

In this study on the toxic effects of chlorpyrifos on aquatic ecosystems, Capoeta umbla fish were used as a model organism. By applying chlorpyrifos to fish at different concentrations (55-110 µg/L) and durations (24 and 96 hours), malondialdehyde (MDA) levels, an indicator of lipid peroxidation in brain tissue, and catalase (CAT) and glutathione reductase (GR) activities, which are important enzymes of the antioxidant defense system, were determined. The results obtained showed that chlorpyrifos triggered oxidative stress in fish, increased lipid peroxidation in cell membranes, and suppressed the antioxidant defense system. This situation emphasizes the negative effects of chlorpyrifos on living organisms in aquatic ecosystems and its environmental risk.

Anahtar Kelimeler

Chlorpyrifos, Capoeta umbla, catalase, antioxidant

Klorpirifosa Maruz Kalan Capoeta Umbla' nın Beyin Dokusunda Antioksidan Yanıtı

Öz

Klorpirifosun su ekosistemleri üzerindeki toksik etkileri üzerine yapılan bu çalışmada, Capoeta umbla türü balıkları model organizma olarak kullanılmıştır. Balıklara farklı konsantrasyonlarda (55-110 µg/L) ve sürede (24 ve 96 saat) klorpirifos uygulanarak, beyin dokusunda lipid peroksidasyonunun bir göstergesi olan malondialdehit (MDA) seviyesi ve antioksidan savunma sisteminin önemli enzimlerinden olan katalaz (CAT) ve glutatyon redüktaz (GR) aktiviteleri belirlenmiştir. Elde edilen sonuçlar, klorpirifosun balıklarda oksidatif stresi tetikleyerek hücre zarlarında lipid peroksidasyonunu artırdığını ve antioksidan savunma sistemini baskıladığını göstermiştir. Bu durum, klorpirifosun su ekosistemlerindeki canlılar üzerindeki olumsuz etkilerini ve çevresel riskini vurgulamaktadır.

Anahtar Kelimeler

Klorpirifos, Capoeta umbla, katalaz, antioksidan.

Kaynakça

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