Autotransporter Proteins
Abstract
Autotransporter proteins, which are examined under five groups on the basis of their secretory systems, constitute the largest protein family found in Gram-negative pathogenic bacteria. The determination that all autotransporter proteins are associated with pathogenicity and virulence in these bacteria has made them the focus of molecular pathogenicity studies. Although the structural organization of autotransporter proteins and the base sequences of the genes encoding them are highly similar, their functions in the strains they are found in show a high diversity. This indicates that pathogen-host adaptation may also result from differences in protein processing and secretion system, and that new and effective approaches can be developed in the fight against pathogens. In this review article, the contemporary literature of this important protein family has been examined, and it has been tried to be interpreted as a basis for new scientific studies.
Keywords
Autotransporter proteins, genetic and biochemical structure, secrettion systems
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