Research Article

Classifying White Blood Cells Using Machine Learning Algorithms

Volume: 11 Number: 1 January 31, 2019
Abdullah Elen *, M. Kamil Turan
EN

Classifying White Blood Cells Using Machine Learning Algorithms

Abstract

Blood and its components have an important place in human life and are the best indicator tool in determining many pathological conditions. In particular, the classification of white blood cells is of great importance for the diagnosis of hematological diseases. In this study, 350 microscopic blood smear images were tested with 6 different machine learning algorithms for the classification of white blood cells and their performances were compared. 35 different geometric and statistical (texture) features have been extracted from blood images for training and test parameters of machine learning algorithms. According to the results, the Multinomial Logistic Regression (MLR) algorithm performed better than the other methods with an average 95% test success. The MLR can be used for automatic classification of white blood cells. It can be used especially as a source for diagnosis of diseases for hematologists and internal medicine specialists.

Keywords

WBC classification,leukocytes,blood cells,machine learning

References

  1. Adjouadi, M., Zong, N. & Ayala, M. (2005). Multidimensional Pattern Recognition and Classification of White Blood Cells Using Support Vector Machines. Particle & Particle Systems Characterization, 22(2): pp. 107-118.
  2. Arı, E., & Yıldız, Z. (2013). Parallel Lines Assumption in Ordinal Logistic Regression and Analysis Approaches. International Interdisciplinary Journal of Scientific Research, 1(3): pp. 8-23.
  3. Avuçlu, E., & Başçiftçi, F. (2018). New approaches to determine age and gender in image processing techniques using multilayer perceptron neural network. Applied Soft Computing, 70, pp. 157–168. doi:10.1016/j.asoc.2018.05.033
  4. Bikhet, S. F., Darwish, A. M., Tolba, H. A. & Shaheen, S. I. (2000). Segmentation and classification of white blood cells. IEEE International Conference on Acoustics, Speech, and Signal Processing, İstanbul, pp. 2259-2261.
  5. Breiman, L. (2001). Random Forests. Machine Learning, 45(1): pp. 5-32.
  6. Büyüköztürk, Ş., Çokluk Bökeoğlu, Ö. & Şekercioğlu, G. (2010). Sosyal Bilimler İçin Çok Değişkenli İstatistik SPSS ve LISREL Uygulamaları. Pegem Akademi Yayıncılık, Ankara, pp. 59-65.
  7. Cortes, C. & Vapnik, V. (1995). Support-Vector Network. Machine Learning, 20(3): pp. 273–297.
  8. Cover, T., & Hart, P. (1967). Nearest Neighbor Pattern Classification. IEEE Transactions on Information Theory, 13(1): 21-27.
  9. Elen, A. & Turan, M. K. (2018). A New Approach for Fully Automated Segmentation of Peripheral Blood Smears. International Journal of Advanced and Applied Sciences, 5(1): pp. 81-93.
  10. Ferri, M., Lombardini, S. & Pallotti, C. (1994). Leukocyte Classification by Size Functions. IEEE Workshop on Applications of Computer Vision, Sarasota, pp. 223-229.
APA
Elen, A., & Turan, M. K. (2019). Classifying White Blood Cells Using Machine Learning Algorithms. International Journal of Engineering Research and Development, 11(1), 141-152. https://doi.org/10.29137/umagd.498372
AMA
1.Elen A, Turan MK. Classifying White Blood Cells Using Machine Learning Algorithms. IJERAD. 2019;11(1):141-152. doi:10.29137/umagd.498372
Chicago
Elen, Abdullah, and M. Kamil Turan. 2019. “Classifying White Blood Cells Using Machine Learning Algorithms”. International Journal of Engineering Research and Development 11 (1): 141-52. https://doi.org/10.29137/umagd.498372.
EndNote
Elen A, Turan MK (January 1, 2019) Classifying White Blood Cells Using Machine Learning Algorithms. International Journal of Engineering Research and Development 11 1 141–152.
IEEE
[1]A. Elen and M. K. Turan, “Classifying White Blood Cells Using Machine Learning Algorithms”, IJERAD, vol. 11, no. 1, pp. 141–152, Jan. 2019, doi: 10.29137/umagd.498372.
ISNAD
Elen, Abdullah - Turan, M. Kamil. “Classifying White Blood Cells Using Machine Learning Algorithms”. International Journal of Engineering Research and Development 11/1 (January 1, 2019): 141-152. https://doi.org/10.29137/umagd.498372.
JAMA
1.Elen A, Turan MK. Classifying White Blood Cells Using Machine Learning Algorithms. IJERAD. 2019;11:141–152.
MLA
Elen, Abdullah, and M. Kamil Turan. “Classifying White Blood Cells Using Machine Learning Algorithms”. International Journal of Engineering Research and Development, vol. 11, no. 1, Jan. 2019, pp. 141-52, doi:10.29137/umagd.498372.
Vancouver
1.Abdullah Elen, M. Kamil Turan. Classifying White Blood Cells Using Machine Learning Algorithms. IJERAD. 2019 Jan. 1;11(1):141-52. doi:10.29137/umagd.498372

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