The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations

Emine Albayrak; Özer Işılar; Mutluhan Bıyıkoğlu; Ayşe Şahin Yağlıoğlu; Adnan Bulut

doi:10.29137/umagd.927358

EN TR

The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations

Abstract

A series of 1-8 different ferrocenyl chalcones were synthesized through the Claisen–Schmidt condensation and the Friedel−Crafts acylation. Their structures were confirmed by means of 1H, 13C NMR and FT-IR. The cytotoxic and antiproliferative activities of the chalcones were screened against HeLa (cervix cancer) and PC3 (prostate cancer) cell lines. They showed excellent anti-cancer activities especially against PC3 cell even at very low concentration (5 µM). Also, their physicochemical properties, drug-likeness calculations and the rule of five (RO5) were investigated.

Keywords

Ferrocene, Chalcone, PC3, HeLa, Anti-cancer, Drug-likeness

Supporting Institution

Scientific Research Projects Coordination Unit of Kırıkkale University

Project Number

2018/85

References

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Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Emine Albayrak This is me
0000-0003-4022-0860
Türkiye

Özer Işılar
0000-0001-7547-2537
Türkiye

Mutluhan Bıyıkoğlu
0000-0003-0752-2242
Türkiye

Ayşe Şahin Yağlıoğlu
0000-0002-7668-6286
Türkiye

Adnan Bulut ^*
0000-0001-9322-0325
Türkiye

Publication Date

June 18, 2021

Submission Date

April 27, 2021

Acceptance Date

June 5, 2021

Published in Issue

Year 2021 Volume: 13 Number: 2

DOI

https://doi.org/10.29137/umagd.927358

IZ

https://izlik.org/JA22ZB32CU

APA

Albayrak, E., Işılar, Ö., Bıyıkoğlu, M., Şahin Yağlıoğlu, A., & Bulut, A. (2021). The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations. International Journal of Engineering Research and Development, 13(2), 690-703. https://doi.org/10.29137/umagd.927358

AMA

1.Albayrak E, Işılar Ö, Bıyıkoğlu M, Şahin Yağlıoğlu A, Bulut A. The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations. IJERAD. 2021;13(2):690-703. doi:10.29137/umagd.927358

Chicago

Albayrak, Emine, Özer Işılar, Mutluhan Bıyıkoğlu, Ayşe Şahin Yağlıoğlu, and Adnan Bulut. 2021. “The Synthesis and Anti-Cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations”. International Journal of Engineering Research and Development 13 (2): 690-703. https://doi.org/10.29137/umagd.927358.

EndNote

Albayrak E, Işılar Ö, Bıyıkoğlu M, Şahin Yağlıoğlu A, Bulut A (June 1, 2021) The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations. International Journal of Engineering Research and Development 13 2 690–703.

IEEE

[1]E. Albayrak, Ö. Işılar, M. Bıyıkoğlu, A. Şahin Yağlıoğlu, and A. Bulut, “The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations”, IJERAD, vol. 13, no. 2, pp. 690–703, June 2021, doi: 10.29137/umagd.927358.

ISNAD

Albayrak, Emine - Işılar, Özer - Bıyıkoğlu, Mutluhan - Şahin Yağlıoğlu, Ayşe - Bulut, Adnan. “The Synthesis and Anti-Cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations”. International Journal of Engineering Research and Development 13/2 (June 1, 2021): 690-703. https://doi.org/10.29137/umagd.927358.

JAMA

1.Albayrak E, Işılar Ö, Bıyıkoğlu M, Şahin Yağlıoğlu A, Bulut A. The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations. IJERAD. 2021;13:690–703.

MLA

Albayrak, Emine, et al. “The Synthesis and Anti-Cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations”. International Journal of Engineering Research and Development, vol. 13, no. 2, June 2021, pp. 690-03, doi:10.29137/umagd.927358.

Vancouver

1.Emine Albayrak, Özer Işılar, Mutluhan Bıyıkoğlu, Ayşe Şahin Yağlıoğlu, Adnan Bulut. The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations. IJERAD. 2021 Jun. 1;13(2):690-703. doi:10.29137/umagd.927358

Kırıkkale University, Faculty of Engineering and Natural Science, 71450 Yahşihan / Kırıkkale, Türkiye.

ijerad@kku.edu.tr

The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations

The Synthesis and Anti-cancer Activities of Ferrocenyl Chalcones; Drug-Likeness Calculations

Abstract

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Ferrosenil Kalkonların Sentezi ve Anti-kanser Aktiviteleri; İlaç Benzerlik Hesaplamaları

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