Yıl 2019, Cilt 11 , Sayı 2, Sayfalar 612 - 619 2019-06-30

Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing

Çağlar Elbüken [1]


Identification and successive separation of cell populations have a vast number of applications in both clinical research and basic sciences. In the last few decades several custom-made microfluidic systems have been developed to address the differentiation needs of the researchers. For all these systems there is a need for focusing the cells of interest in the interrogation zone during the flow. In this article, a new method of viscoelastic focusing was used for this purpose. By adding polymeric materials into the carrying fluid, elastic lift force was generated on the cells that allows passive particle focusing. Once the cells are aligned with the sensor, detection and identification was achieved using impedance characterization. The carrier fluid properties were investigated to achieve successful viscoelastic focusing and impedimetric detection. Two blood cell types, red blood cells and white blood cells, were differentiated based on their impedance signal. In addition to its capability as a microfluidic cell counter, this work reveals the possibility of using viscoelastic focusing for flow through impedance based particle characterization.
Microfluidics, cell counting, impedance detection, viscoelastic focusing
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Birincil Dil en
Konular Mühendislik, Ortak Disiplinler
Bölüm Makaleler
Yazarlar

Orcid: 0000-0001-8359-6871
Yazar: Çağlar Elbüken
Kurum: İHSAN DOĞRAMACI BİLKENT ÜNİVERSİTESİ, ULUSAL NANOTEKNOLOJİ UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 30 Haziran 2019

Bibtex @araştırma makalesi { umagd532269, journal = {International Journal of Engineering Research and Development}, issn = {}, eissn = {1308-5514}, address = {Kırıkkale Üniversitesi Mühendislik Fakültesi Dekanlığı Kampüs 71450 Yahşihan/KIRIKKALE}, publisher = {Kırıkkale Üniversitesi}, year = {2019}, volume = {11}, pages = {612 - 619}, doi = {10.29137/umagd.532269}, title = {Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing}, key = {cite}, author = {Elbüken, Çağlar} }
APA Elbüken, Ç . (2019). Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing. International Journal of Engineering Research and Development , 11 (2) , 612-619 . DOI: 10.29137/umagd.532269
MLA Elbüken, Ç . "Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing". International Journal of Engineering Research and Development 11 (2019 ): 612-619 <https://dergipark.org.tr/tr/pub/umagd/issue/43865/532269>
Chicago Elbüken, Ç . "Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing". International Journal of Engineering Research and Development 11 (2019 ): 612-619
RIS TY - JOUR T1 - Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing AU - Çağlar Elbüken Y1 - 2019 PY - 2019 N1 - doi: 10.29137/umagd.532269 DO - 10.29137/umagd.532269 T2 - International Journal of Engineering Research and Development JF - Journal JO - JOR SP - 612 EP - 619 VL - 11 IS - 2 SN - -1308-5514 M3 - doi: 10.29137/umagd.532269 UR - https://doi.org/10.29137/umagd.532269 Y2 - 2019 ER -
EndNote %0 Uluslararası Mühendislik Araştırma ve Geliştirme Dergisi Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing %A Çağlar Elbüken %T Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing %D 2019 %J International Journal of Engineering Research and Development %P -1308-5514 %V 11 %N 2 %R doi: 10.29137/umagd.532269 %U 10.29137/umagd.532269
ISNAD Elbüken, Çağlar . "Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing". International Journal of Engineering Research and Development 11 / 2 (Haziran 2019): 612-619 . https://doi.org/10.29137/umagd.532269
AMA Elbüken Ç . Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing. IJERAD. 2019; 11(2): 612-619.
Vancouver Elbüken Ç . Impedimetric Cell Detection using Microfluidic Viscoelastic Focusing. International Journal of Engineering Research and Development. 2019; 11(2): 619-612.