The effect of ginger essential oil (Zingiber officinale) on catalase in rat kidney tissue

Year 2024, , 87 - 95, 22.08.2024

Yağmur Yıldız Asker , Şükran Aras , Mükremin Ölmez , Hasan Asker , Mustafa Makav , Arzu Gezer , Tarkan Şahin

https://doi.org/10.31797/vetbio.1415244

Abstract

We were aimed to investigate the effect of ginger essential oil (Zingiber officinale) on catalase release in rat kidney tissue by histopathological and immunohistochemically method. This study, 21 male Wistar albino rats were used. Rats were divided into three groups: control, 100 mg/kg ginger essential oil (G100), and 500 mg/kg ginger essential oil (G500). Hematoxylin-eosin staining method was used for histopathological evaluations. Immunohistochemically localization of catalase in kidney tissue was determined by streptavidin-biotin peroxidase method. As a result of histopathological evaluations, an increase in glomerulus diameter was observed in kidney tissues of G100 and G500 groups. In addition, vacuolar degeneration was observed in the proximal and distal tubule epithelial cells in the renal cortex of the G100 group. The immunoreactivity of catalase in the renal cortex region; In the control group, it is strong in the proximal tubules and weak in the mesangial cells. While moderate severity in the proximal tubules and weak in the mesangial cells in the G100 group, very weak catalase immunoreactivity was observed in the G500 group. Strong catalase immunoreactivity was detected in the proximal and collecting ducts of the kidney medulla regions of the rats in all groups. We think that ginger essential oil can be used in appropriate doses and times to reduce kidney damage caused by oxidative stress in the kidney.

Keywords

Catalase, ginger essential oil, kidney

Ethical Statement

This study was carried out at Kafkas University Reserch Animals Application Center. This research was approved by The Ethics Committee of the Faculty of Veterinary Medicine, Kafkas University (KAU-HADYEK, Ref No:2021/035 Date: 25.03.2021)

Thanks

Histopathological results were evaluation Prof. Dr. Mahmut Sözmen in the patology Depertment Faculty of Veterinary Medicine, Ondokuz Mayıs University. Thanks to Mahmut Sözmen for contribution.

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