Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690)

Sinem Pehlivan; İlker Şimşek; Eda Akdağ; Ali Fatih Yıltırak; Pınar Arslan Yüce; Özgür Kuzukıran; Ayhan Filazi

doi:10.31797/vetbio.1863533

Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690)

Abstract

Glioblastoma multiforme (GBM) constitutes a significant majority of glial-derived tumors. It has a poor prognosis. It is highly aggressive and malignant. In this disease, where treatment methods can be used alone or in combination, localization and, consequently, accessibility are among the most important factors affecting treatment. Nanoparticle-based approaches, such as silver-based nanoparticles containing different silver forms like AgNO₃, AgMP, and AgNP, are emerging as potential agents in tumor treatment. This study aimed to determine the effects of silver nanoparticles of different sizes on GBM cell viability. The results obtained revealed that AgNP exposure produced a highly cytotoxic effect and that the cytotoxic properties of AgMPs were lower compared to the other silver forms examined in our study. Although further research is needed regarding their ability to cross the blood-brain barrier, AgNPs can be considered as potential agents that can be effectively used in GBM treatment due to their potent inhibitory effects.

Keywords

References

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Details

Primary Language

English

Subjects

Veterinary Pharmacology

Journal Section

Research Article

Authors

Sinem Pehlivan ^*
0000-0002-3389-3189
Türkiye

İlker Şimşek
0000-0001-9181-9879
Türkiye

Eda Akdağ
0000-0001-9132-4438
Türkiye

Ali Fatih Yıltırak
0000-0001-9835-4584
Türkiye

Pınar Arslan Yüce
0000-0001-5910-2835
Türkiye

Özgür Kuzukıran
0000-0001-9294-2801
Türkiye

Ayhan Filazi
0000-0002-2800-6215
Türkiye

Publication Date

May 6, 2026

Submission Date

January 15, 2026

Acceptance Date

April 5, 2026

Published in Issue

Year 2026 Number: 2

DOI

https://doi.org/10.31797/vetbio.1863533

IZ

https://izlik.org/JA24MT24PS

Cite

RIS / Bibtex

APA

Pehlivan, S., Şimşek, İ., Akdağ, E., Yıltırak, A. F., Arslan Yüce, P., Kuzukıran, Ö., & Filazi, A. (2026). Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). Journal of Advances in VetBio Science and Techniques, 2, 92-96. https://doi.org/10.31797/vetbio.1863533

AMA

1.Pehlivan S, Şimşek İ, Akdağ E, et al. Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). J Ad VetBio Sci Tech. 2026;(2):92-96. doi:10.31797/vetbio.1863533

Chicago

Pehlivan, Sinem, İlker Şimşek, Eda Akdağ, et al. 2026. “Comparison of the Effects of Nano, Micro Silver Particles, and Silver Nitrate on Glioblastoma Multiforme (CRL-1690)”. Journal of Advances in VetBio Science and Techniques, nos. 2: 92-96. https://doi.org/10.31797/vetbio.1863533.

EndNote

Pehlivan S, Şimşek İ, Akdağ E, Yıltırak AF, Arslan Yüce P, Kuzukıran Ö, Filazi A (May 1, 2026) Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). Journal of Advances in VetBio Science and Techniques 2 92–96.

IEEE

[1]S. Pehlivan et al., “Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690)”, J Ad VetBio Sci Tech, no. 2, pp. 92–96, May 2026, doi: 10.31797/vetbio.1863533.

ISNAD

Pehlivan, Sinem - Şimşek, İlker - Akdağ, Eda - Yıltırak, Ali Fatih - Arslan Yüce, Pınar - Kuzukıran, Özgür - Filazi, Ayhan. “Comparison of the Effects of Nano, Micro Silver Particles, and Silver Nitrate on Glioblastoma Multiforme (CRL-1690)”. Journal of Advances in VetBio Science and Techniques. 2 (May 1, 2026): 92-96. https://doi.org/10.31797/vetbio.1863533.

JAMA

1.Pehlivan S, Şimşek İ, Akdağ E, Yıltırak AF, Arslan Yüce P, Kuzukıran Ö, Filazi A. Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). J Ad VetBio Sci Tech. 2026;:92–96.

MLA

Pehlivan, Sinem, et al. “Comparison of the Effects of Nano, Micro Silver Particles, and Silver Nitrate on Glioblastoma Multiforme (CRL-1690)”. Journal of Advances in VetBio Science and Techniques, no. 2, May 2026, pp. 92-96, doi:10.31797/vetbio.1863533.

Vancouver

1.Sinem Pehlivan, İlker Şimşek, Eda Akdağ, Ali Fatih Yıltırak, Pınar Arslan Yüce, Özgür Kuzukıran, Ayhan Filazi. Comparison of the effects of nano, micro silver particles, and silver nitrate on glioblastoma multiforme (CRL-1690). J Ad VetBio Sci Tech. 2026 May 1;(2):92-6. doi:10.31797/vetbio.1863533