Research Article

Effect of age on oxidative stress and hematological parameters in healthy male dogs

Number: 3 October 17, 2026

Effect of age on oxidative stress and hematological parameters in healthy male dogs

Abstract

This study aimed to evaluate the effect of age on oxidative stress and hematological parameters in healthy dogs by measuring malondialdehyde (MDA) and glutathione peroxidase (GPx) levels. A total of 46 healthy male dogs were divided into two groups: 3-8 months (n=23) and 2-4 years (n=23). All animals were clinically examined and maintained under identical housing and feeding conditions. Hematological parameters were analyzed using an automated analyzer, and serum MDA and GPx levels were measured by ELISA. Data were analyzed using independent samples t-test. RBC, HGB, and HCT values were significantly lower in young dogs (p<0.05), while WBC and lymphocyte counts were significantly higher (p<0.05). MDA levels were significantly higher in young dogs (p<0.001), whereas GPx activity was significantly higher in adult dogs (p<0.01). Young dogs are more susceptible to oxidative stress, while antioxidant defense mechanisms improve with age. These findings emphasize the importance of age-specific clinical evaluation and nutritional strategies.

Keywords

Supporting Institution

TÜBİTAK

Project Number

1919B012409717

Ethical Statement

This study was approved by Yozgat Bozok University Animal Experiments Local Ethics Committee (Decision No: 10, Meeting No: 2025/4).

Thanks

We would like to thank the TÜBİTAK institution and its staff for supporting this project.

References

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Details

Primary Language

English

Subjects

Veterinary Internal Medicine

Journal Section

Research Article

Publication Date

October 17, 2026

Submission Date

May 7, 2026

Acceptance Date

September 27, 2026

Published in Issue

Year 2026 Number: 3

APA
Sayar, E., & Koca, Z. (2026). Effect of age on oxidative stress and hematological parameters in healthy male dogs. Journal of Advances in VetBio Science and Techniques, 3, 267-271. https://doi.org/10.31797/vetbio.1946283
AMA
1.Sayar E, Koca Z. Effect of age on oxidative stress and hematological parameters in healthy male dogs. J Ad VetBio Sci Tech. 2026;(3):267-271. doi:10.31797/vetbio.1946283
Chicago
Sayar, Emre, and Zeynep Koca. 2026. “Effect of Age on Oxidative Stress and Hematological Parameters in Healthy Male Dogs”. Journal of Advances in VetBio Science and Techniques, nos. 3: 267-71. https://doi.org/10.31797/vetbio.1946283.
EndNote
Sayar E, Koca Z (October 1, 2026) Effect of age on oxidative stress and hematological parameters in healthy male dogs. Journal of Advances in VetBio Science and Techniques 3 267–271.
IEEE
[1]E. Sayar and Z. Koca, “Effect of age on oxidative stress and hematological parameters in healthy male dogs”, J Ad VetBio Sci Tech, no. 3, pp. 267–271, Oct. 2026, doi: 10.31797/vetbio.1946283.
ISNAD
Sayar, Emre - Koca, Zeynep. “Effect of Age on Oxidative Stress and Hematological Parameters in Healthy Male Dogs”. Journal of Advances in VetBio Science and Techniques. 3 (October 1, 2026): 267-271. https://doi.org/10.31797/vetbio.1946283.
JAMA
1.Sayar E, Koca Z. Effect of age on oxidative stress and hematological parameters in healthy male dogs. J Ad VetBio Sci Tech. 2026;:267–271.
MLA
Sayar, Emre, and Zeynep Koca. “Effect of Age on Oxidative Stress and Hematological Parameters in Healthy Male Dogs”. Journal of Advances in VetBio Science and Techniques, no. 3, Oct. 2026, pp. 267-71, doi:10.31797/vetbio.1946283.
Vancouver
1.Emre Sayar, Zeynep Koca. Effect of age on oxidative stress and hematological parameters in healthy male dogs. J Ad VetBio Sci Tech. 2026 Oct. 1;(3):267-71. doi:10.31797/vetbio.1946283

 

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