Vital-supporting new therapy in dogs with systemic inflammatory response syndrome and possible bacterial translocation: application of high-volume polyethylene glycol with proctolysis

Abstract

In the study of retrospective case series, it was aimed to restrained of sepsis as reconstructing the intestinal barrier via high volume polyethylene glycol administration by rectal enema (proctolysis) in dogs being systemic inflammatory response syndrome with possible bacterial translocation accompanied by laboratory analysis. Regarding high volume polyethylene glycol was administered rectally with standard treatment protocols in 8 different dogs diagnosed different diseases and concomitant with systemic inflammatory response syndrome. It was observed to the systemic inflammatory response scores was 2-4 before the polyethylene glycol application, decreased 0-1 after 5 days of application. In this respect, the use of polyethylene glycol via rectal enema has been demonstrated as a first in this study in cases applied to clinics with systemic inflammatory response syndrome and sepsis and we have also received the absence of any side effects favorably although in a limited number of cases.

Keywords

• dog
• rectal enema
• polyethylene glycol
• SIRS

Sistemik inflamatuvar cevap sendromu ve muhtemel bakteriyel translokasyonu mevcut köpeklerde vital destekleyici yeni sağaltım: proktolizis ile yüksek hacimde polietilen glikol uygulaması

Öz

Retrospektif vaka serisine ait çalışmada laboratuvar analizleri eşliğinde sistemik inflamatuvar cevap sendromu ile muhtemel bakteriyel translokasyonu mevcut köpeklerde, rektal enema (proktolizis) ile yüksek hacimde polietilen glikol uygulamasının bağırsak bariyerini yeniden inşaası ile sepsisin durdurulması amaçlandı. Bu kapsamda farklı hastalıkları bulunan ve sistemik inflamatuvar cevap sendromu eşlik eden 8 farklı köpekte standart sağaltım protokolleri ile rektal yolla yüksek hacimde polietilen glikol uygulandı. Polietilen glikol uygulama öncesi 2-4 arası saptanan sistemik inflamatuvar cevap skorlarında 5 günlük uygulama sonrası 0-1 arasına düştüğü gözlemlendi. Bu yönü ile sınırlı sayıda olguda da olsa, kliniklerde sistemik inflamatuvar cevap sendromu ve sepsis durumlarında bu çalışmada bir ilk olduğu üzere rektal enema ile polietilen glikol kullanılabilirliği ortaya konulmuş olup herhangi bir yan etki saptanmaması yine tarafımızca olumlu karşılanmıştır.

Anahtar Kelimeler

• köpek
• rektal enema
• polietilen glikol
• SIRS

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