Functional paraganglioma of bladder: A case report

Abstract

Extraadrenal phoechromacytomas are also called paragangliomas that were firstly described by Zimmerman at 1953. Less than 1% of all paragangliomas are genitourinary paragangliomas. Bladder is the most affected organ in the urinary system also renal pelvis and ureter was less affected than bladder too. It was frequently occured 20-40 years age women population.The symptoms of patients are related to cathecolamins that was secreted by tumour and the most of symptoms are hypertension, headache, hematuria and syncope/palpitation. In our case presentation, we aimed to discuss treatment of bladder paraganglioma that occured in 56 years age male patient with current literature. 

Keywords

• Paraganglioma
• bladder
• sur- gical treatment

Fonksiyonel mesane paraganglioması: Olgu sunumu

Abstract

İlk olarak 1953 yılında Zimmerman tarafından tanımlanan extraadrenal feokromasitomalar, paraganglioma olarak isimlendirilir. Genito üriner paraganglioma, tüm paragangliomaların %1’inden azını oluşturmaktadır. Üriner sistemde en sık olarak etkilenen organ mesanedir. Daha az sıklıkla renal pelvis ve üreter etkilenmektedir. Sıklıkla 20-40 yaş arası kadınlarda izlenmektedir. Hastaların semptomları tümörün salgıladığı katekolaminler ile ilişkilidir ve en sık hipertansiyon, baş ağrısı, hematüri ve senkop/palpitasyondur. Biz bu vaka sunumumuzda 56 yaşındaki erkek hastada saptadığımız mesane paragangliomasının tedavisini literatür eşliğinde tartışmayı amaçladık. 

Keywords

• Paraganglioma
• me- sane
• cerrahi tedavi

References

1. 1. Zimmerman IJ, Bıron RE, Macmahon HE. Pheochromocy- toma of the urinary bladder. N Engl J Med 1953;2:249:25-6.
2. 2. Lack EE, Cubilla AL, Woodruff JM, Farr HW. Paraganglio- mas of the head and neck region: a clinical study of 69 patients. Cancer 1977;39:397-409.
3. 3. Ueda N, Yoshida A, Fukunishi R, Fujita H, Yanagihara N.Nonchromaffin paraganglioma in the nose and paranasal sinuses. Acta Pathol Jpn 1985;35:489-95.
4. 4. Sheps SG, Jiang NS, Klee GG, et al. Recent developments in the diagnosis and treatment of pheochromocytoma. Mayo Clin Proc 1990;65:88–95.
5. 5. Pastor-Guzman JM, Lopez-García S, Gimenez-Bachs JM,et al. Paraganglioma of the bladder: controversy regarding treatment. Urol Int 2004;73:270-5.
6. 6. Doran F, Varinli S, Bayazit Y, Bal N, Özdemir S. Pheochro-mocytoma of the urinary bladder. APMIS 2002;110:733-6.
7. 7. Beilan JA, Lawton A, Hajdenberg J, Rosser CJ. Pheochro- mocytoma of the urinary bladder: a systematic review of the contemporary literature. BMC Urol 2013;29:13-22.
8. 8. Bhalani SM, Casalino DD, Manvar AM. Paraganglioma of bladder. Journal of Urology 2011;160:279-80.

9. 9. Neumann HPH, Bausch B, McWhinney SR, et al. Germ- line mutations in nonsyndromic pheochromocytoma. N Engl J Med 2002;346:1459-66.
10. 10. Lalloo F. Diagnosis and Management of Hereditary Phae-ochromocytoma and Paraganglioma. Recent Result Cancer Res 2016;205:105-24.
11. 11. Lenders JW, Pacak K, Walther MM. Biochemical diag- nosis of pheochromocytoma: which test is best? JAMA 2002;287:1427-34.
12. 12. Zelinka T, Eisenhofer G, Pacak K. Pheochromocytoma as a catecholamine producing tumor: implications for clinical practice. Stress 2007;10:195-203.
13. 13. Intenzo CM, Jabbour S, Lin HC, et al. Scintigraphic ima- ging of body neuroendocrine tumors.Radiographics 2007;27:1355-69.
14. 14. Jain TK, Basher RK, Gupta N, Shukla J, Singh SK, Mittal BR. Unusual Presentation of Bladder Paraganglioma: Com- parison of (131)I MIBG SPECT/CT and (68)Ga DOTA- NOCPET/CT. World J Nucl Med 2016;15:65-7.
15. 15. Yang C, Liu Z, Lan R, et al. Paraganglioma of the urinary bladder with chromosome duplications detected by fluores- cence in situ hybridization in urine exfoliated cells: A case report. Oncoll lett 2016;11:795-7.
16. 16. Tregliaa G, Ceriania L, Merlob E, Rubertoa T, Paonea G, Giovanellaa L. Added value of fused somatostatin recep- tor imaging/magnetic resonance imaging in a rare case of paraganglioma of the urinary bladder. Rev Esp Med Nucl Imagen Mol 2014;33:122-4.
17. 17. Ercil H, Unal U, Gurlen G, Sener NC, Cinar T, EvliyaogluY. A Rare Case: Sporadic Bladder Paraganglioma. Cukurova Med J 2013;38:794-9.