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Atopik Hastalık Tanısıyla Takipli Hastalarda İmmünglobülin A Eksikliği İnsidansı

Year 2016, Volume: 2 Issue: 1, 176 - 186, 15.01.2016
https://doi.org/10.30569/adiyamansaglik.351627

Abstract

Amaç: İmmünglobülin
A eksikliği ile atopik hastalıklar arasındaki ilişkiyi incelemek.

Materyal ve metod: Atopik
hastalık tanılı 68’i erkek, 35’i kız toplam 103 hastanın dosyaları geriye dönük
olarak incelendi. Hastaların yaş, cinsiyet, atopik hastalık tanıları, eşlik
eden hastalıkları, ailede atopi öyküsü, gaytada parazit testi, deri prick testi
sonuçları, immünglobülin A, G, M, E ve eozinofil düzeyleri kaydedildi.
İmmünglobülin düzeyleri nephelometrik yöntemle ölçüldü. Üç hasta, IgM ve/veya IgG
düzeyleri yaşa göre düşük bulunduğu için çalışma dışı bırakıldı.

Bulgular: Atopik
hastalık tanısıyla takip edilen hastaların 7’sinde IgA düzeyleri yaşa göre düşük
bulunurken sadece 1 hastada 5mg/dl’nin altında bulundu. Selektif IgA eksikliği
sıklığı hasta grubumuzda %1 olarak hesaplandı. IgA eksikliği bulunan hastaların
tümü erkekti ve cinsiyetler arasındaki fark istatistiksel olarak anlamlı
bulundu (p꞊0.043). IgA düzeyi düşük olanlarla normal olanlar arasında ailede
atopi öyküsü açısından fark saptanmadı (p꞊0.34). IgA eksikliği bulunan
hastaların tümünde astım öyküsü vardı ancak diğer atopik hastalıklar yoktu. IgA
eksikliği bulunanlar ile normal sınırlarda olan atopik hastaların eozinofil ve
IgE düzeyleri arasında fark saptanmadı.







Sonuç: Atopik hastalarda IgA eksikliği sıklığının
genel popülasyonda görülen Selektif IgA eksikliği sıklığından farklı
olmadığını, bu nedenle de atopik hastalıklar ile IgA eksikiği arasında doğrudan
bir ilişki olmadığını düşünüyoruz.

References

  • 1. Aberg N, Hesselmar B, Aberg B, Eriksson B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 1995;25:815-9.
  • 2. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H; ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-43.
  • 3. Kim HY, Kwon EB, Baek JH, Shin YH, Yum HY, Jee HM, Yoon JW, Han MY. Prevalence and comorbidity of allergic diseases in preschool children. Korean J Pediatr 2013;56(8):338-42.
  • 4. Borrego LM, César M, Leiria-Pinto P, Rosado-Pinto JE. Prevalence of asthma in a Portuguese countryside town: repercussions on absenteeism and self-concept. Allergol Immunopathol (Madr) 2005;33(2):93-9.
  • 5. Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008;452(7188):773-6.
  • 6. Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs. Eur Respir J 1999;13(1):8-14.
  • 7. Aghamohammadi A, Cheraghi T, Gharagozlou M, Movahedi M, Rezaei N, Yeganeh M, Parvaneh N, Abolhassani H, Pourpak Z, Moin M. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol 2009;29(1):130-6.
  • 8. Taylor B, Norman AP, Orgel HA, Stokes CR, Turner MW, Soothill JF. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet 1973;2(7821):111-3.
  • 9. National Heart, Lung, and Blood Institute; National Institutes of Health. Global strategy for asthma mana- gement and prevention: Global Initative for Asthma (GINA): 2008 update (Internet). Available from:http//www.ginaasthma.org.
  • 10. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization GA(2)LEN and Aller- Gen). Allergy 2008;63 (Suppl 86):8-160. 11. Böhme M, Svensson A, Kull I, Wahlgren CF. Hanifin’s and Rajka’s minor criteria for atopic dermatitis: Which do 2-year-olds exhibit? J Am Acad Dermatol 2000;43 (5 pt 1):785-92.
  • 12. Illi S, Weber J, Zutavern A, Genuneit J, Schierl R, Strunz-Lehner C, von Mutius E. Perinatal influences on the development of asthma and atopy in childhood. Ann Allergy Asthma Immunol 2014;112(2):132-139.
  • 13. Artaç H, Keleş S, Karagöl C, Göktürk B, Reisli İ. İmmünglobulin A eksikliğinde atopi ve allerjik hastalıklar(Atopy and allergic diseases in immunoglobulin A deficiency). Asthma Allergy Immunol 2012;10:25-30.
  • 14. Bazin H, Pauwels R. IgE and IgG2a isotypes in the rat. Progr Allergy 1982;32:52-73.
  • 15. Machtinger S, Moss R. Cow’s milk allergy in breast-fed infants: the role of allergen and maternal secretory IgA antibody. Allergy Clin Immunol 1986;77:341-47.
  • 16. Buse WW. The relationship between viral infections and onset of allergic disease and asthma. Clin and Exp Allergy 1989;19:1-9.
  • 17. Gathmann B, Binder N, Ehl S, Kindle G; ESID Registry Working Party. The European internet-based patient and research database for primary immunodeficiencies: update 2011. Clin Exp Immunol 2012;167(3):479-91.
  • 18. Tomasi TB. The discovery secretory IgA and mucosal immune system. Immunol Today 1992;13:416-18.
  • 19. Mietens C. Selective IgA deficiency. Clin Paediatr 1983;195(6):385-87.
  • 20. Kaufman HS, Hodds JR. Immunglobulin deficiencies in an atopic population. Lancet 1970;2:1061-63.
  • 21. Hobbs JR. IgA as a safer form of antibody response. Protides in Biological Fluids 1978;25:865-72.
  • 22. Östergaard PAA. Clinical and immunological features of transient IgA deficiency in children. Clin Exp Immunol 1980;40:561-65.
  • 23. Domínguez O, Giner MT, Alsina L, Martín MA, Lozano J, Plaza AM. [Clinical phenotypes associated with selective IgA deficiency: a review of 330 cases and a proposed follow-up protocol]. An Pediatr (Barc) 2012;76(5):261-7.
  • 24. Brasher GW, Bourland PD. The role of IgA in the pathogenesis of atopy. Ann Allergy 1975;34(3):137-40.
  • 25. Plebani A, Monafo V, Ugazio AG, Monti C, Avanzini MA, Massimi P. Comparison of the frequency of atopic disease in children with severe and partial IgA deficiency. Int Arch Allergy Appl Immunol 987;82(3-4):485-86.
  • 26. Frick OL, German DF, Mills J. Development of allergy in children. J Allergy Clin Immunol 1979;63:228-41.
  • 27. Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A, Valdimarsson H. Correlation between serum immunglobulin A concentrations and allergic manifestations in infants. J Pediatric 1992;121(1):23-27.
  • 28. Urm SH, Yun HD, Fenta YA, Yoo KH, Abraham RS, Hagan J, Juhn YJ. Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study. Mayo Clin Proc 2013;88(8):813-21.
  • 29. Voltz JM, Mole C, Aubin F, Gibey R, Faivre B. Serum and salivary immunglobulins A in atopic dermatitis. Prospective and comparative case control study. Ann Dermatol Venereol 1998;125(2):100-104.
  • 30. Taylor B, Fergusson DM, Mahoney GN. Specific IgA and IgE in childhood asthma, eczema and food allergy. Clin Allergy 1982;12(5):499-505.
Year 2016, Volume: 2 Issue: 1, 176 - 186, 15.01.2016
https://doi.org/10.30569/adiyamansaglik.351627

Abstract

References

  • 1. Aberg N, Hesselmar B, Aberg B, Eriksson B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 1995;25:815-9.
  • 2. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H; ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-43.
  • 3. Kim HY, Kwon EB, Baek JH, Shin YH, Yum HY, Jee HM, Yoon JW, Han MY. Prevalence and comorbidity of allergic diseases in preschool children. Korean J Pediatr 2013;56(8):338-42.
  • 4. Borrego LM, César M, Leiria-Pinto P, Rosado-Pinto JE. Prevalence of asthma in a Portuguese countryside town: repercussions on absenteeism and self-concept. Allergol Immunopathol (Madr) 2005;33(2):93-9.
  • 5. Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008;452(7188):773-6.
  • 6. Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs. Eur Respir J 1999;13(1):8-14.
  • 7. Aghamohammadi A, Cheraghi T, Gharagozlou M, Movahedi M, Rezaei N, Yeganeh M, Parvaneh N, Abolhassani H, Pourpak Z, Moin M. IgA deficiency: correlation between clinical and immunological phenotypes. J Clin Immunol 2009;29(1):130-6.
  • 8. Taylor B, Norman AP, Orgel HA, Stokes CR, Turner MW, Soothill JF. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet 1973;2(7821):111-3.
  • 9. National Heart, Lung, and Blood Institute; National Institutes of Health. Global strategy for asthma mana- gement and prevention: Global Initative for Asthma (GINA): 2008 update (Internet). Available from:http//www.ginaasthma.org.
  • 10. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization GA(2)LEN and Aller- Gen). Allergy 2008;63 (Suppl 86):8-160. 11. Böhme M, Svensson A, Kull I, Wahlgren CF. Hanifin’s and Rajka’s minor criteria for atopic dermatitis: Which do 2-year-olds exhibit? J Am Acad Dermatol 2000;43 (5 pt 1):785-92.
  • 12. Illi S, Weber J, Zutavern A, Genuneit J, Schierl R, Strunz-Lehner C, von Mutius E. Perinatal influences on the development of asthma and atopy in childhood. Ann Allergy Asthma Immunol 2014;112(2):132-139.
  • 13. Artaç H, Keleş S, Karagöl C, Göktürk B, Reisli İ. İmmünglobulin A eksikliğinde atopi ve allerjik hastalıklar(Atopy and allergic diseases in immunoglobulin A deficiency). Asthma Allergy Immunol 2012;10:25-30.
  • 14. Bazin H, Pauwels R. IgE and IgG2a isotypes in the rat. Progr Allergy 1982;32:52-73.
  • 15. Machtinger S, Moss R. Cow’s milk allergy in breast-fed infants: the role of allergen and maternal secretory IgA antibody. Allergy Clin Immunol 1986;77:341-47.
  • 16. Buse WW. The relationship between viral infections and onset of allergic disease and asthma. Clin and Exp Allergy 1989;19:1-9.
  • 17. Gathmann B, Binder N, Ehl S, Kindle G; ESID Registry Working Party. The European internet-based patient and research database for primary immunodeficiencies: update 2011. Clin Exp Immunol 2012;167(3):479-91.
  • 18. Tomasi TB. The discovery secretory IgA and mucosal immune system. Immunol Today 1992;13:416-18.
  • 19. Mietens C. Selective IgA deficiency. Clin Paediatr 1983;195(6):385-87.
  • 20. Kaufman HS, Hodds JR. Immunglobulin deficiencies in an atopic population. Lancet 1970;2:1061-63.
  • 21. Hobbs JR. IgA as a safer form of antibody response. Protides in Biological Fluids 1978;25:865-72.
  • 22. Östergaard PAA. Clinical and immunological features of transient IgA deficiency in children. Clin Exp Immunol 1980;40:561-65.
  • 23. Domínguez O, Giner MT, Alsina L, Martín MA, Lozano J, Plaza AM. [Clinical phenotypes associated with selective IgA deficiency: a review of 330 cases and a proposed follow-up protocol]. An Pediatr (Barc) 2012;76(5):261-7.
  • 24. Brasher GW, Bourland PD. The role of IgA in the pathogenesis of atopy. Ann Allergy 1975;34(3):137-40.
  • 25. Plebani A, Monafo V, Ugazio AG, Monti C, Avanzini MA, Massimi P. Comparison of the frequency of atopic disease in children with severe and partial IgA deficiency. Int Arch Allergy Appl Immunol 987;82(3-4):485-86.
  • 26. Frick OL, German DF, Mills J. Development of allergy in children. J Allergy Clin Immunol 1979;63:228-41.
  • 27. Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A, Valdimarsson H. Correlation between serum immunglobulin A concentrations and allergic manifestations in infants. J Pediatric 1992;121(1):23-27.
  • 28. Urm SH, Yun HD, Fenta YA, Yoo KH, Abraham RS, Hagan J, Juhn YJ. Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study. Mayo Clin Proc 2013;88(8):813-21.
  • 29. Voltz JM, Mole C, Aubin F, Gibey R, Faivre B. Serum and salivary immunglobulins A in atopic dermatitis. Prospective and comparative case control study. Ann Dermatol Venereol 1998;125(2):100-104.
  • 30. Taylor B, Fergusson DM, Mahoney GN. Specific IgA and IgE in childhood asthma, eczema and food allergy. Clin Allergy 1982;12(5):499-505.
There are 29 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Mehmet Tekin

Selçuk Uzuner

Hasan Önal

Rengin Şiraneci This is me

Publication Date January 15, 2016
Submission Date November 13, 2017
Acceptance Date November 22, 2017
Published in Issue Year 2016 Volume: 2 Issue: 1

Cite

AMA Tekin M, Uzuner S, Önal H, Şiraneci R. Atopik Hastalık Tanısıyla Takipli Hastalarda İmmünglobülin A Eksikliği İnsidansı. ADYÜ Sağlık Bilimleri Derg. April 2016;2(1):176-186. doi:10.30569/adiyamansaglik.351627