Therapy Resistant Hypothyroidism

Year 2018, Volume: 18 Issue: 2, 235 - 241, 25.06.2018

Oya Topaloğlu Bekir Çakır

https://doi.org/10.17098/amj.435289

Abstract

Hypothyroidism is a common problem in
the population. Standard therapy for hypothyroidism is the replacement with
synthetic L-thyroxine (L-T4) sodium preparations. The target of the treatment is
to maintain TSH levels between normal reference values. Detection of the
underlying reason can be difficult in patients with higher L-T4 dose
requirement than expected. In these patients, primarily non-adherence to the
therapy should be remembered and then, whether there is an underlying reason or
not should be investigated. 

Keywords

Hypothyroidism, therapy, resistant

Tedaviye Dirençli Hipotiroidi

Abstract

Hipotiroidi toplumda sık görülen bir
problemdir. Hipotiroidinin standart tedavisi sentetik L-tiroksin (L-T4) sodyum
preparatları ile replasmandır. Tedavide hedef TSH’yı normal referans değerleri
arasında tutmaktır. Beklenen dozların üzerinde L-T4 gereksinimi olan hastalarda
altta yatan nedeni tespit etmek zor olabilir. Bu hastalarda öncelikli olarak
ilaç alımında uyumsuzluk düşünülmeli ve sonra da altta yatan biyolojik bir
neden olup olmadığı da araştırılmalıdır.

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Keywords

Hipotiroidi, tedavi, dirençli

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