Advance stage small cell neuroendocrine carcinoma of cervix: A case report

Year 2013, Volume: 18 Issue: 1, 41 - 44, 02.05.2013

Yasam Kemal Akpak İsmet Gun

Abstract

Abstract.Neuroendocrine small cell carcinoma of the uterine cervix is an entity withvery aggressive behaviour. The optimal initial therapeutic approach to thisrare disease has not yet been clearly defined. These tumors are difficult tomanage. It is often diagnosed at an advanced stage and its prognosis isgenerally poor. In this paper, a 44-year-old woman with small cellneuroendocrine tumor of the cervix presenting with widespread metastasis isreported. Literature provides limited research on the issue and the reportedresearch involves only small series and case reports on neuroendocrine small cellcervical carcinoma. Neuroendocrine differentiation can be shown by severalmethods. The most important of all these methods is immunohistochemical study.Surgery, radiotherapy, and chemotherapy have been used either alone or incombination. The purpose of this case is to evaluate this rarely seen,aggressive, malignant cervical tumor with poor prognosis, and thus, make somecontribution to the literature.Key words: Chemoradiotherapy, immunohistochemical study, neuroendocrinesmall cell carcinoma

Keywords

Chemoradiotherapy, immunohistochemical study, neuroendocrine small cell carcinoma

References

• Pazdur R, Boromi P, Slayton R, et al. Neuroendocrine carcinoma of the cervix: implications for staging and therapy. Gynecol Oncol 1981; 12: 120-128.
• Wells M, Nesland JM, Oster AG, et al. Epithelial tumors. In: Tavassoli FA, Devilee P, editors. World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs. Lyon (France): IARC. Press 2003: 279.
• Mullins JD, Hilliard GD. Cervical carcinoid ("Argyrophil cell" carcinoma) associated with an endocervical adenocarcinoma. A light and ultrastructural study. Cancer 1981; 47: 785-790.
• Ishida GM, Kato N, Hayasaka T, et al. Small cell neuroendocrine carcinomas of the uterine cervix: A histological, immunohistochemical, and molecular genetic study. Int J Gynecol Pathol 2004; 23: 366-372. Piehl MR, Gould VE, Warren WH, et al. Immunohistochemical identification of exocrine and neuroendocrine subsets of large cell lung carcinomas. Pathol Res Pract 1988; 183: 675-682.
• Boruta DM 2nd, Schorge JO, Duska LA, et al. Multimodality therapy in early stage neuroendocrine carcinoma of the uterine cervix. Gynecol Oncol 2001; 81: 82-87.
• McCusker ME, Cote TR, Clegg LX, et al. Endocrin tumors of the uterine cervix: Incidence, demographics and survival with comparison to squamous cell carcinoma. Gynecol Oncol 2003; 88: 333-339.
• Chan JK, Loizzi V, Burger RA, et al. Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. Cancer 2003; 97: 568-5
• Lee JM, Lee KB, Nam JH, et al. Prognostic factors in FIGO stage IB-IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: results of a multi-center retrospective Korean study. Ann Oncol 2008; 19: 321-326.
• Cohen JG, Kapp DS, Shin JY, et al. Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol 2010; 203: 347.