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Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls

Year 2018, Volume: 8 Issue: 3, 151 - 154, 18.12.2018
https://doi.org/10.32448/entupdates.499028

Abstract










Objective: Autologous serum skin testing is a practical test
for basophil histamine release which is used in the diagnosis of
chronic autoimmune urticaria. Although the exact autoimmune
pathogenesis of allergic diseases of the upper respiratory tract
remains a matter of debate, recent studies have reported positive
autologous serum skin tests in both allergic and non-allergic
rhinitis, asthma sufferers, and even in healthy controls. In this
study, we aim to evaluate positive results from autologous serum
testing in hayfever sufferers and to compare the results with those
from healthy controls.




Materials and methods




The study included 76 seasonal allergic rhinitis patients aged
between 18-65 years and 51 healthy volunteers who underwent
autologous serum skin testing. The Chi-squared test was used for
comparisons between the two groups.




Result




Autologous serum testing proved positive in 29 of the patients with
allergic rhinitis and in 10 of the healthy controls. The number of
positive results from autologous serum testing was found to be
significantly higher in patients with allergic rhinitis than in the
control group.




Conclusion




From the results of this research and the information found in the
literature, it appears that autologous serum skin testing has uses
beyond merely detecting chronic urticaria. There may be an advantage
in evaluating the common features and serum factor in patients with
allergic rhinitis and urticaria who show positivity to autologous
serum skin testing.




References

  • 1- Kakli HA, RileyTD. Allergic rhinitis. Prim Care 2016;43:465-75.
  • 2- Skoner DP. Allergic rhinitis: Definition, epidemiology, pathopysiology, detection and diagnosis. J Allergy Clin Immunol 2001;108:2-8.
  • 3- Khan DA. Allergic rhinitis and asthma: Epidemiology and common pathophysiology. Allergy Asthma Proc 2014;35:357-61.
  • 4- Kumaran MS, Mangal S, Narang T, Parsad D. Autologous serum and plasma skin test in chronic spontaneous urticaria: A reappraisal. Ind Dermatol Online J 2017;8:94-99.
  • 5- Grattan CEH. Autoimmune urticaria. Immunol Allergy Clin North Am 2004;24:163-81.
  • 6- Asero R, Lorini M, Chong SU, Zuberbier T, Tedeschi A. Assesment of histamin-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells. Clin Exp Allergy 2004;34:1111-1114.
  • 7- Mari A. Allergy-like asthma and rhinitis – a cross sectional survey of a respiratory cohort and a diagnostic approach using the autologous serum skin test. Int Arch Allergy Immunol 2004;133:29-39
  • 8- Tedeschi A, Comi AL, Lorini M et al. Autologous serum skin test reactivity in patients with non-allergic asthma. Clin Exp Allergy 2005;35:849-53.
  • 9- Asero R, Tedeschi A, Lorini M. Autoreactivity is highly prevalent in patients with multiple intolerances to NSAIDs. Ann Allergy Asthma Immunol 2002;88:468-72.
  • 10- Asero R, Tedeschi A, Lorini M et al. Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. Int Arch Allergy Immunol 2003;131:195-200.
  • 11- Guttman-Yassky E, Bergman R, Maor C et al. The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals. J Eur Acad Dermatol Venereol 2007;21:35-9.
  • 12- Sabroe RA, Fiebiger E, Francis DM et al. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol 2002;110:492-499.
  • 13- Toubi E, Kessel A, Avshovich N et al. Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy 2004;59:869-873.
  • 14- Zuberbier T, Henz BM, Fieebiger E, Maurer D, Stingl G. Anti-FcepsilonRIalpha autoantibody in different subtypes of urticaria. Allergy 2000;55:951-954.
  • 15- Horn MP, Gerster T, Ochensberger B et al. Human antiFcepsilonRI alpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur J Immunol 1999;29: 1139-1148.
  • 16- Taşkapan O, Kutlu A, Karabudak O. Evaluation of autologous serum skin test results in patients with chronic urticaria, allergic/non-allergic asthma or rhinitis and healhy people. Clin Exp Dermatol 2008;33:754-8.
  • 17- Marasoğlu Çelen O, Kutlubay Z, Aydemir EH. Usefulness of the autologous serum test for the diagnosis of chronic idiopathic urticaria. Ann Dermatol 2014;26:592-597.
  • 18- Kurt E, Aktaş A, Aksu K. Autologous serum skin test response in chronic spontaneous urticaria and respiratory disease and it’s relationship with serum interleukin-18 level. Arch Dermatol Res 2011;303:643-649.
Year 2018, Volume: 8 Issue: 3, 151 - 154, 18.12.2018
https://doi.org/10.32448/entupdates.499028

Abstract

References

  • 1- Kakli HA, RileyTD. Allergic rhinitis. Prim Care 2016;43:465-75.
  • 2- Skoner DP. Allergic rhinitis: Definition, epidemiology, pathopysiology, detection and diagnosis. J Allergy Clin Immunol 2001;108:2-8.
  • 3- Khan DA. Allergic rhinitis and asthma: Epidemiology and common pathophysiology. Allergy Asthma Proc 2014;35:357-61.
  • 4- Kumaran MS, Mangal S, Narang T, Parsad D. Autologous serum and plasma skin test in chronic spontaneous urticaria: A reappraisal. Ind Dermatol Online J 2017;8:94-99.
  • 5- Grattan CEH. Autoimmune urticaria. Immunol Allergy Clin North Am 2004;24:163-81.
  • 6- Asero R, Lorini M, Chong SU, Zuberbier T, Tedeschi A. Assesment of histamin-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells. Clin Exp Allergy 2004;34:1111-1114.
  • 7- Mari A. Allergy-like asthma and rhinitis – a cross sectional survey of a respiratory cohort and a diagnostic approach using the autologous serum skin test. Int Arch Allergy Immunol 2004;133:29-39
  • 8- Tedeschi A, Comi AL, Lorini M et al. Autologous serum skin test reactivity in patients with non-allergic asthma. Clin Exp Allergy 2005;35:849-53.
  • 9- Asero R, Tedeschi A, Lorini M. Autoreactivity is highly prevalent in patients with multiple intolerances to NSAIDs. Ann Allergy Asthma Immunol 2002;88:468-72.
  • 10- Asero R, Tedeschi A, Lorini M et al. Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. Int Arch Allergy Immunol 2003;131:195-200.
  • 11- Guttman-Yassky E, Bergman R, Maor C et al. The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals. J Eur Acad Dermatol Venereol 2007;21:35-9.
  • 12- Sabroe RA, Fiebiger E, Francis DM et al. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol 2002;110:492-499.
  • 13- Toubi E, Kessel A, Avshovich N et al. Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy 2004;59:869-873.
  • 14- Zuberbier T, Henz BM, Fieebiger E, Maurer D, Stingl G. Anti-FcepsilonRIalpha autoantibody in different subtypes of urticaria. Allergy 2000;55:951-954.
  • 15- Horn MP, Gerster T, Ochensberger B et al. Human antiFcepsilonRI alpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur J Immunol 1999;29: 1139-1148.
  • 16- Taşkapan O, Kutlu A, Karabudak O. Evaluation of autologous serum skin test results in patients with chronic urticaria, allergic/non-allergic asthma or rhinitis and healhy people. Clin Exp Dermatol 2008;33:754-8.
  • 17- Marasoğlu Çelen O, Kutlubay Z, Aydemir EH. Usefulness of the autologous serum test for the diagnosis of chronic idiopathic urticaria. Ann Dermatol 2014;26:592-597.
  • 18- Kurt E, Aktaş A, Aksu K. Autologous serum skin test response in chronic spontaneous urticaria and respiratory disease and it’s relationship with serum interleukin-18 level. Arch Dermatol Res 2011;303:643-649.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Aslıhan Çakır Akay This is me

Esin Yalçınkaya

Publication Date December 18, 2018
Submission Date September 30, 2018
Published in Issue Year 2018 Volume: 8 Issue: 3

Cite

APA Çakır Akay, A., & Yalçınkaya, E. (2018). Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls. ENT Updates, 8(3), 151-154. https://doi.org/10.32448/entupdates.499028
AMA Çakır Akay A, Yalçınkaya E. Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls. ENT Updates. December 2018;8(3):151-154. doi:10.32448/entupdates.499028
Chicago Çakır Akay, Aslıhan, and Esin Yalçınkaya. “Evaluation of Positive Results for Autologous Serum Skin Testing in Patients With Seasonal Allergic Rhinitis Compared With Healthy Controls”. ENT Updates 8, no. 3 (December 2018): 151-54. https://doi.org/10.32448/entupdates.499028.
EndNote Çakır Akay A, Yalçınkaya E (December 1, 2018) Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls. ENT Updates 8 3 151–154.
IEEE A. Çakır Akay and E. Yalçınkaya, “Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls”, ENT Updates, vol. 8, no. 3, pp. 151–154, 2018, doi: 10.32448/entupdates.499028.
ISNAD Çakır Akay, Aslıhan - Yalçınkaya, Esin. “Evaluation of Positive Results for Autologous Serum Skin Testing in Patients With Seasonal Allergic Rhinitis Compared With Healthy Controls”. ENT Updates 8/3 (December 2018), 151-154. https://doi.org/10.32448/entupdates.499028.
JAMA Çakır Akay A, Yalçınkaya E. Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls. ENT Updates. 2018;8:151–154.
MLA Çakır Akay, Aslıhan and Esin Yalçınkaya. “Evaluation of Positive Results for Autologous Serum Skin Testing in Patients With Seasonal Allergic Rhinitis Compared With Healthy Controls”. ENT Updates, vol. 8, no. 3, 2018, pp. 151-4, doi:10.32448/entupdates.499028.
Vancouver Çakır Akay A, Yalçınkaya E. Evaluation of positive results for autologous serum skin testing in patients with seasonal allergic rhinitis compared with healthy controls. ENT Updates. 2018;8(3):151-4.