Research Article
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Evaluation of Kidneys with Renal Doppler Ultrasonography and Ultrasound Elastography in Patients with Type 2 Diabetes Mellitus

Year 2023, Volume: 20 Issue: 3, 555 - 559, 31.12.2023
https://doi.org/10.35440/hutfd.1320159

Abstract

Introduction: The aim of this study early recognize diabetic nephropathy by ultrasound elastography.This study was to predict the possibility of developing diabetic nephropathy without the need for renal biopsy.

Methods:This study included 100 patients and 100 healthy volunteers. Shear wave elastography examination were taken of the renal parenchyma and the Resistive Index values were taken renal artery.

Results:.In the patient group, the elastography values were measured as 7.02±2.15 kPa in the right kidney parenchyma and 6.90±2.09 kPa in the left. In the control group, the elasticity values were measured as 4.14±0.98 kPa in the right kidney parenchyma and 4.11±0.85 kPa in the left. The RI mean values were determined as 0.59±0.05 in the right kidney and 0.59±0.04 in the left kidney in the patient group and 0.52±0.05 in the right kidney and 0.52±0.05 in the left kidney in the control group.

Conclusion: The elastography values and the RI values were significantly higher in the patients with Type 2 DM than in the control group. Thus, it can be concluded that it is possible to determine renal fibrosis and predict the possibility of diabetic nephropathy development with the non-invasive methods of SWE and colour Doppler US, without the need for biopsy.

References

  • 1. Satman I, Yilmaz T, Sengul A, et al.Population-based study of diabetes and risc characteristics in Turkey: results of the Tur-kish diabetes epidemiology study (TUR-DEP).Diabetes Care 2002;25:1551-1556.
  • 2. Satman I, Tutuncu Y, Gedik S, et al. The TURDEP-II Study Group, Diabetes epidemic in Turkey: Results of the second population based survey of diabetes and risk characteristics in Turkey (TURDEP-II). Poster: A-11-2498. 47th EASD Annual Meeting, 12-16 Sept 2011, Lisbon, Portugal. Diabetologia 2011; 2498-2499.
  • 3. El Nahas AM. Growth factors and glomerular sclerosis. Kidney Int Suppl 1992;36: 15-20.
  • 4. Balleyguier C, Ciolovan L, Ammari S, et al. Breast elastography: The technical process and its applications. Diagn Interv Ima-ging 2013; 94: 503–513.
  • 5. Tublin ME, Bude RO, Platt JF. The resistive index in renal Doppler sonography: Where do we stand? Am J Roentgenol 2003;180:885–892.
  • 6. Taş S, Onur MR, Yılmaz S, et al. Shear Wave Elastography Is a Reliableand Repeatable Methodfor Measuring the Elastic Modulus of theRectus Femoris Muscleand Patellar Tendon. J UltrasoundMed 2017;36: 565-570.
  • 7. Rübenthaler J, Müller-Peltzer K, Reiser M, et al. [Sonoelastog-raphy in dailyclinicalroutine] Radiologe 2017; 17: 17-224.
  • 8. Dr. A.Yiğit Göktay, Dr. Adnan Kabaalioğlu, Dr. Cem Yücel DDA. Renal Renkli Doppler Ultrasonografi İncelemesi Uygulama Kı-lavuzu. Tıbbi Ultrason Derneği. 2006.
  • 9. Mogensen CE, Christensen CK, Vittinghus E. The stages in diabetic renal disease. With emphasis on the stage of incipi- ent diabetic nephropathy. Diabetes 1983;32: 64-78.
  • 10. Kahn CR, Weir GC, King GL, et al. Joslin's Diabetes Mellitus Yumuk M (çev.ed) İstanbul Medikal Yayıncılık, 2008; 331-339.
  • 11. Klein R, Klein B. Epidemiology of proliferative diabetic retino-pathy. Diabetes Care 1992; 15: 1875–1891.
  • 12. Akahashi T, Wang F, Quarles CC, et al. Current MRI Techniques for the Assessment of Renal Disease. Curr Opin Nephrol He-pertens 2016;24: 217–223.
  • 13. Sar MA. Elastography Usage in Renal Patients Turkish Nephrol Dial Transplant J 2017; 26: 18–20.
  • 14. Galesić K, Sabljar-Matovinović M, Tomić M BB. Renal Vascular Resistance in Glomerular Diseases – Correlation of Resistance Index with Biopsy Findings. Coll Antropol 2004;28: 667– 674.
  • 15. Koc, AS & Sumbul, HE J Ultrason 2018; 21: 279-80.
  • 16. Hassan K, Loberant N, Abbas N, et al. Shear wave elastog-raphy imaging for assessing the chronic pathologic changes in advanced diabetic kidney disease. Ther Clin Risk Manag 2016;12: 1615–1622.
  • 17. Samir AE, Allegretti AS, Zhu Q, et al. Shear wave elastography in chronic kidney disease: A pilot experience in native kidneys. BMC Nephrol 2015;16: 119-120.
  • 18. Grass, L., Szekely, N., Alrajab, A, et al. Pointshear wave elas-tography (pSWE) using Acoustic Radiation Force Impulse (AR-FI) imaging: a feasibility study and norm values for renal pa-renchymal stiffness in healthy children and adolescentsMedi-cal Ultrasonography 2017;19: 366-373.
  • 19. Fiorini F, Barozzi L. The role of ultrasonography in the study of medical nephropathy. J Ultrasound 2007;10:161–167.
  • 20. Tatsuo Kawai, Kei Kamide, Miyuki Onishi, et al. Usefulness of the resistive index in renal Doppler ultrasonography as an in-dicator of vascular damage in patients with risks of atheroscle-rosis, Nephrology Dialysis Transplantation 2011;26:3256–3262
  • 21. Toledo C, Thomas G, Schold JD, et al. Renal Resistive Index and Mortality in Chronic Kidney Disease. Hypertension 2015.
  • 22. Ohta Y, Fujii K, Arima H, et al. Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Dopp-ler sonography. J Hypertens 2015;23: 1905–1911.

Tip 2 Diabetes Mellituslu Hastalarda Böbreklerin Renal Doppler Ultrasonografi ve Ultrason Elastografi ile Değerlendirilmesi

Year 2023, Volume: 20 Issue: 3, 555 - 559, 31.12.2023
https://doi.org/10.35440/hutfd.1320159

Abstract

Amaç: Bu çalışmanın amacı diyabetik nefropatiyi ultrason elastografi ile erken teşhis etmektir. Bu çalışma renal biyopsiye gerek kalmadan diyabetik nefropati gelişme olasılığını tahmin etmektir.

Materyal ve metod: Bu çalışmaya 100 hasta ve 100 sağlıklı gönüllü dahil edildi. Renal parankimden shear wave elastografi incelemesi ve renal arter Resistive Index değerleri alındı.

Bulgular: Hasta grubunda elastografi değerleri sağ böbrek parankiminde 7,02±2,15 kPa, solda 6,90±2,09 kPa olarak ölçüldü. Kontrol grubunda elastisite değerleri sağ böbrek parankiminde 4,14±0,98 kPa, solda 4,11±0,85 kPa olarak ölçüldü. RI ortalama değerleri hasta grubunda sağ böbrekte 0,59±0,05 ve sol böbrekte 0,59±0,04, kontrol grubunda sağ böbrekte 0,52±0,05 ve sol böbrekte 0,52±0,05 olarak ölçüldü.

Sonuç: Tip 2 DM'li hastalarda elastografi değerleri ve RI değerleri kontrol grubuna göre anlamlı olarak yüksekti. Böylece non-invazif SWE ve renkli Doppler US yöntemleri ile biyopsiye gerek kalmadan böbrek fibrozisini belirlemenin ve diyabetik nefropati gelişme olasılığını tahmin etmenin mümkün olduğu söylenebilir.

References

  • 1. Satman I, Yilmaz T, Sengul A, et al.Population-based study of diabetes and risc characteristics in Turkey: results of the Tur-kish diabetes epidemiology study (TUR-DEP).Diabetes Care 2002;25:1551-1556.
  • 2. Satman I, Tutuncu Y, Gedik S, et al. The TURDEP-II Study Group, Diabetes epidemic in Turkey: Results of the second population based survey of diabetes and risk characteristics in Turkey (TURDEP-II). Poster: A-11-2498. 47th EASD Annual Meeting, 12-16 Sept 2011, Lisbon, Portugal. Diabetologia 2011; 2498-2499.
  • 3. El Nahas AM. Growth factors and glomerular sclerosis. Kidney Int Suppl 1992;36: 15-20.
  • 4. Balleyguier C, Ciolovan L, Ammari S, et al. Breast elastography: The technical process and its applications. Diagn Interv Ima-ging 2013; 94: 503–513.
  • 5. Tublin ME, Bude RO, Platt JF. The resistive index in renal Doppler sonography: Where do we stand? Am J Roentgenol 2003;180:885–892.
  • 6. Taş S, Onur MR, Yılmaz S, et al. Shear Wave Elastography Is a Reliableand Repeatable Methodfor Measuring the Elastic Modulus of theRectus Femoris Muscleand Patellar Tendon. J UltrasoundMed 2017;36: 565-570.
  • 7. Rübenthaler J, Müller-Peltzer K, Reiser M, et al. [Sonoelastog-raphy in dailyclinicalroutine] Radiologe 2017; 17: 17-224.
  • 8. Dr. A.Yiğit Göktay, Dr. Adnan Kabaalioğlu, Dr. Cem Yücel DDA. Renal Renkli Doppler Ultrasonografi İncelemesi Uygulama Kı-lavuzu. Tıbbi Ultrason Derneği. 2006.
  • 9. Mogensen CE, Christensen CK, Vittinghus E. The stages in diabetic renal disease. With emphasis on the stage of incipi- ent diabetic nephropathy. Diabetes 1983;32: 64-78.
  • 10. Kahn CR, Weir GC, King GL, et al. Joslin's Diabetes Mellitus Yumuk M (çev.ed) İstanbul Medikal Yayıncılık, 2008; 331-339.
  • 11. Klein R, Klein B. Epidemiology of proliferative diabetic retino-pathy. Diabetes Care 1992; 15: 1875–1891.
  • 12. Akahashi T, Wang F, Quarles CC, et al. Current MRI Techniques for the Assessment of Renal Disease. Curr Opin Nephrol He-pertens 2016;24: 217–223.
  • 13. Sar MA. Elastography Usage in Renal Patients Turkish Nephrol Dial Transplant J 2017; 26: 18–20.
  • 14. Galesić K, Sabljar-Matovinović M, Tomić M BB. Renal Vascular Resistance in Glomerular Diseases – Correlation of Resistance Index with Biopsy Findings. Coll Antropol 2004;28: 667– 674.
  • 15. Koc, AS & Sumbul, HE J Ultrason 2018; 21: 279-80.
  • 16. Hassan K, Loberant N, Abbas N, et al. Shear wave elastog-raphy imaging for assessing the chronic pathologic changes in advanced diabetic kidney disease. Ther Clin Risk Manag 2016;12: 1615–1622.
  • 17. Samir AE, Allegretti AS, Zhu Q, et al. Shear wave elastography in chronic kidney disease: A pilot experience in native kidneys. BMC Nephrol 2015;16: 119-120.
  • 18. Grass, L., Szekely, N., Alrajab, A, et al. Pointshear wave elas-tography (pSWE) using Acoustic Radiation Force Impulse (AR-FI) imaging: a feasibility study and norm values for renal pa-renchymal stiffness in healthy children and adolescentsMedi-cal Ultrasonography 2017;19: 366-373.
  • 19. Fiorini F, Barozzi L. The role of ultrasonography in the study of medical nephropathy. J Ultrasound 2007;10:161–167.
  • 20. Tatsuo Kawai, Kei Kamide, Miyuki Onishi, et al. Usefulness of the resistive index in renal Doppler ultrasonography as an in-dicator of vascular damage in patients with risks of atheroscle-rosis, Nephrology Dialysis Transplantation 2011;26:3256–3262
  • 21. Toledo C, Thomas G, Schold JD, et al. Renal Resistive Index and Mortality in Chronic Kidney Disease. Hypertension 2015.
  • 22. Ohta Y, Fujii K, Arima H, et al. Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Dopp-ler sonography. J Hypertens 2015;23: 1905–1911.
There are 22 citations in total.

Details

Primary Language English
Subjects Radiology and Organ Imaging
Journal Section Research Article
Authors

Atakan Kırteke 0000-0001-9256-7060

Sunay Sibel Karayol 0000-0002-2696-3580

Abdurrahim Dusak 0000-0002-4363-5861

Canan Çelebi 0000-0001-7871-9005

Hatice İncebiyik 0000-0002-7550-8218

Early Pub Date November 21, 2023
Publication Date December 31, 2023
Submission Date June 26, 2023
Acceptance Date August 6, 2023
Published in Issue Year 2023 Volume: 20 Issue: 3

Cite

Vancouver Kırteke A, Karayol SS, Dusak A, Çelebi C, İncebiyik H. Evaluation of Kidneys with Renal Doppler Ultrasonography and Ultrasound Elastography in Patients with Type 2 Diabetes Mellitus. Harran Üniversitesi Tıp Fakültesi Dergisi. 2023;20(3):555-9.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty