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HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS

Year 2020, Volume: 21 Issue: 1, 125 - 128, 20.03.2020
https://doi.org/10.18229/kocatepetip.460178

Abstract



Venöz
tromboembolizm, derin ven trombozu ve/veya pulmoner emboli olarak görülen ciddi
bir klinik durumdur. Derin ven trombozunun ilk atağını geçiren hastalarda
tekrarlama riski artmıştır. Trombofili tromboza yatkınlık olarak tanımlanır ve
kalıtsal ya da kazanılmış olabilir. Herediter trombofili idiyopatik pulmoner
embolizm ve rekürrensi için önemli bir risk faktörüdür. Heterozigot protrombin
G20210A mutasyonu herediter trombofilinin genetik bir formudur ve herediter koagülasyon
bozukluklarının ikinci en sık nedenidir. Bu yazıda tekrarlayan pulmoner emboli
ve abdominal aortada mural trombüs ile başvuran ve herediter trombofili tespit
edilen 76 yaşında bir erkek hastayı sunduk. Bu olgu tekrarlayan pulmoner
embolide altta yatan sebebin araştırılması gerektiğini vurgulamak için
sunulmuştur.




References

  • 1. Tapson VF. Acute pulmonary embolism. N Engl J Med 2008; 358(10):1037-52.
  • 2. Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med 2004;117(1):19-25.
  • 3. Couturaud F, Leroyer C, Julian JA, Kahn SR, Ginsberg JS, Wells PS, et al. Factors that predict risk of thrombosis in relatives of pa¬tients with unprovoked venous thromboembolism. Chest 2009;136(6):1537-45.
  • 4. Brouwer JL, Lijfering WM, Ten Kate MK, Kluin-Nelemans HC, Veeger NJ, van der Meer J. High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary defi¬ciencies of protein S, protein C or antithrombin. Thromb Haemost 2009;101(1):93-9.
  • 5. Cohoon KP, Heit JA. Inherited and secondary thrombophilia. Circulation. 2014;129(2):254-7.
  • 6. Zhu T, Martinez I, Emmerich J. Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol. 2009;29(3):298-310.
  • 7. Simioni P, Prandoni P, Lensing AW, Manfrin D, Tormene D, Gavasso S, et al. Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. Blood. 2000;96(10):3329-33.
  • 8. Miles JS, Miletich JP, Goldhaber SZ, Hennekens CH, Ridker PM. G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism. J Am Coll Cardiol. 2001;37(1):215-8.
  • 9. Tait RC, Walker ID, Reitsma PH, Islam SI, McCall F, Poort SR, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost. 1995;73(1):87-93.
  • 10. Allaart CF, Aronson DC, Ruys T, Rosendaal FR, van Bockel JH, Bertina RM, et al. Hereditary protein S deficiency in young adults with arterial occlusive disease. Thromb Haemost. 1990;64(2):206-10.

RECURRENT PULMONARY EMBOLISM AND ABDOMINAL AORTIC MURAL THROMBUS IN THE PATIENT WITH HEREDITARY THROMBOPHILIA

Year 2020, Volume: 21 Issue: 1, 125 - 128, 20.03.2020
https://doi.org/10.18229/kocatepetip.460178

Abstract

Venous thromboembolism is a serious clinical condition that manifests as deep venous thrombosis and/or pulmonary embolism. Patients with a first episode of venous thromboembolism are at an increased risk of new episodes. Thrombophilia is defined as a predisposition to thrombosis and may be inherited or acquired. Hereditary thrombophilia is a major risk factor for idiopathic pulmonary embolism and its recurrence. Prothrombin G20210A heterozygosity is a genetic form of thrombophilia named for a specific mutation and is the second common cause of inherited coagulation disorders. We present case of a 76-year-old male patient presenting with recurrent pulmonary embolism and abdominal aortic mural thrombus who was detected hereditary thrombophilia. The casewas presented in order to emphasize that etiology should be investigated in recurrent pulmonary embolism.

References

  • 1. Tapson VF. Acute pulmonary embolism. N Engl J Med 2008; 358(10):1037-52.
  • 2. Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med 2004;117(1):19-25.
  • 3. Couturaud F, Leroyer C, Julian JA, Kahn SR, Ginsberg JS, Wells PS, et al. Factors that predict risk of thrombosis in relatives of pa¬tients with unprovoked venous thromboembolism. Chest 2009;136(6):1537-45.
  • 4. Brouwer JL, Lijfering WM, Ten Kate MK, Kluin-Nelemans HC, Veeger NJ, van der Meer J. High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary defi¬ciencies of protein S, protein C or antithrombin. Thromb Haemost 2009;101(1):93-9.
  • 5. Cohoon KP, Heit JA. Inherited and secondary thrombophilia. Circulation. 2014;129(2):254-7.
  • 6. Zhu T, Martinez I, Emmerich J. Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol. 2009;29(3):298-310.
  • 7. Simioni P, Prandoni P, Lensing AW, Manfrin D, Tormene D, Gavasso S, et al. Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. Blood. 2000;96(10):3329-33.
  • 8. Miles JS, Miletich JP, Goldhaber SZ, Hennekens CH, Ridker PM. G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism. J Am Coll Cardiol. 2001;37(1):215-8.
  • 9. Tait RC, Walker ID, Reitsma PH, Islam SI, McCall F, Poort SR, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost. 1995;73(1):87-93.
  • 10. Allaart CF, Aronson DC, Ruys T, Rosendaal FR, van Bockel JH, Bertina RM, et al. Hereditary protein S deficiency in young adults with arterial occlusive disease. Thromb Haemost. 1990;64(2):206-10.
There are 10 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Case Report
Authors

Nuri Köse

Tarık Yıldırım

Gökhan Ergün This is me

İbrahim Altun

Fatih Akın

Publication Date March 20, 2020
Acceptance Date February 20, 2019
Published in Issue Year 2020 Volume: 21 Issue: 1

Cite

APA Köse, N., Yıldırım, T., Ergün, G., Altun, İ., et al. (2020). HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS. Kocatepe Tıp Dergisi, 21(1), 125-128. https://doi.org/10.18229/kocatepetip.460178
AMA Köse N, Yıldırım T, Ergün G, Altun İ, Akın F. HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS. KTD. March 2020;21(1):125-128. doi:10.18229/kocatepetip.460178
Chicago Köse, Nuri, Tarık Yıldırım, Gökhan Ergün, İbrahim Altun, and Fatih Akın. “HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS”. Kocatepe Tıp Dergisi 21, no. 1 (March 2020): 125-28. https://doi.org/10.18229/kocatepetip.460178.
EndNote Köse N, Yıldırım T, Ergün G, Altun İ, Akın F (March 1, 2020) HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS. Kocatepe Tıp Dergisi 21 1 125–128.
IEEE N. Köse, T. Yıldırım, G. Ergün, İ. Altun, and F. Akın, “HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS”, KTD, vol. 21, no. 1, pp. 125–128, 2020, doi: 10.18229/kocatepetip.460178.
ISNAD Köse, Nuri et al. “HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS”. Kocatepe Tıp Dergisi 21/1 (March 2020), 125-128. https://doi.org/10.18229/kocatepetip.460178.
JAMA Köse N, Yıldırım T, Ergün G, Altun İ, Akın F. HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS. KTD. 2020;21:125–128.
MLA Köse, Nuri et al. “HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS”. Kocatepe Tıp Dergisi, vol. 21, no. 1, 2020, pp. 125-8, doi:10.18229/kocatepetip.460178.
Vancouver Köse N, Yıldırım T, Ergün G, Altun İ, Akın F. HEREDİTER TROMBOFİLİLİ HASTADA TEKRARLAYAN PULMONER EMBOLİ VE ABDOMİNAL AORTADA MURAL TROMBÜS. KTD. 2020;21(1):125-8.

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