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Association between MDR 1 (ABCB1) gene C3435T, C1236T, G2677T/A, A2956G polymorphisms and the risk of breast cancer among Turkish Women

Year 2020, Volume: 27 Issue: 3, 345 - 352, 01.09.2020
https://doi.org/10.17343/sdutfd.650471

Abstract

Objective: The most
common malignancy in women is breast cancer worldwide. Previous studies
performed in different populations have suggested an association between
Multi-Drug Resistance (MDR1) gene polymorphisms and breast cancer risk in
women. The purpose of the current study is to examine relationship between MDR1
polymorphisms (C3435T, G2677T/A, C1236T, A2956G) and the risk of breast cancer
in Turkish women.

Methods: In this study
35 breast cancer cases and 20 healthy controls were enrolled. Identification
of MDR1 genotypes was performed with the polymerase chain reaction/restriction
fragment length polymorphism (PCR-RFLP) technique.

Results: We observed
significant difference in distribution of C3435T genotypes between the cases
and the controls (cases, CC 37.1%, CT 28.6%, and TT 34.3%; controls, CC 25%, CT
65%, and TT 10%, p: 0.023). On the other hand, no significant differences in
genotype and allele frequencies of C1236T and G2677T/A polymorphisms were
observed between groups. We also found that all subjects carry AA genotype for
A2956G polymorphism.







Conclusion: Although our study group is small, the results suggest that the MDR1
C3435T polymorphism may increase the breast cancer risk in Turkish women.

Supporting Institution

Research Projects Committee of Afyon Kocatepe University

Project Number

Project Number: BAP08.TIP.13

References

  • 1. Yan C, Sun C, Ding X, Rizeq FK, Ren M, Yang F, et al. Association of CAV1 polymorphisms with the risks of breast cancer: A systematic review and meta-analysis. Pathol Res Pract 2019; 28: 152518. (https://www.ncbi.nlm.nih.gov/pubmed/term=Yan+C%2C+Sun+C%2C+Ding+X%2C+Rizeq+FK%2C+Ren+M%2C+Yang+F)
  • 2. Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global Cancer in Women: Burden and Trends. Cancer Epidemiol Biomarkers Prev 2017; 26(4): 444-457. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Torre+LA%2C+Islami+F%2C+Siegel+RL%2C+Ward+EM%2C+Jemal+A.)
  • 3. Özmen V. Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients). J Breast Health 2014; 10(2): 98-105. (https://www.ncbi.nlm.nih.gov/pubmed/28331652)
  • 4. Wang Z, Wang T, Bian J. Association between MDR1 C3435T polymorphism and risk of breast cancer. Gene 2013; 532(1): 94-9. (https://www.ncbi.nlm.nih.gov/pubmed/24070710)
  • 5. Gao L, Yang Y, Song S, Hong H, Zhao X, Li D. The association between genetic variant of MDR1 gene and breast cancer risk factors in Chinese women. Int Immunopharmacol 2013; 17(1): 88-91. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Gao+L%2C+Yang+Y%2C+Song+S%2C+Hong+H%2C+Zhao+X%2C+Li+D.)
  • 6. Abuhaliema AM, Yousef AM, Elmadany NN, Bulatova NR, Awwad NM, Yousef MA, et al. Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer--a Case-Control Study in Jordan. Asian Pac J Cancer Prev 2016; 17(1): 261-6. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Abuhaliema+AM%2C+Yousef+AM%2C+Elmadany+NN%2C+Bulatova+NR%2C+Awwad+NM%2C+Yousef+MA)
  • 7. Sheng X, Zhang L, Tong N, Luo D, Wang M, Xu M, et al. MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies. Mol Biol Rep 2012; 39(7): 7237-49. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Sheng+X%2C+Zhang+L%2C+Tong+N%2C+Luo+D%2C+Wang+M%2C+Xu+M%2C)
  • 8. Turgut S, Yaren A, Kursunluoglu R, Turgut G. MDR1 C3435T Polymorphism in Patients with Breast Cancer. Arch Med Res 2007; 38(5): 539-44. (https://www.ncbi.nlm.nih.gov/pubmed/17560460)
  • 9. Tatari F, Salek R, Mosaffa F, Khedri A, Behravan J. Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian population. DNA Cell Biol 2009; 28(5): 259-63. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tatari+F%2C+Salek+R%2C+Mosaffa+F%2C+Khedri+A%2C+Behravan+J.)
  • 10. Mijac D, Vukovic-Petrovic I, Mijac V, Perovic V, Milic N, Djuranovic S, et al. MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease. PLoS One 2018;13(3):e0194536. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Mijac+D%2C+Vukovic-Petrovic+I%2C+Mijac+V%2C+Perovic+V%2C+Milic+N%2C+Djuranovic+S)
  • 11. Stańko G, Kamiński M, Bogacz A, Seremak-Mrozikiewicz A, Kosiński B, Bartkowiak-Wieczorek J, et al. The importance of G2677T/A and C3435T polymorphisms of the MDR1 gene in the etiology of colorectal cancer. Prz Gastroenterol 2016; 11(1): 35-40. (https://www.ncbi.nlm.nih.gov/pubmed/?term=11.%09Sta%C5%84ko+G%2C+Kami%C5%84ski+M%2C+Bogacz+A%2C+Seremak-Mrozikiewicz+A%2C+Kosi%C5%84ski+B%2C+Bartkowiak-Wieczorek+J)
  • 12. Yin G, Xiao Z, Ni Y, Qu X, Wu H, Lu H, et al. Association of MDR1 single-nucleotide polymorphisms and haplotype variants with multiple myeloma in Chinese Jiangsu Han population. Tumour Biol 2016; 37(7): 9549-54. (https://www.ncbi.nlm.nih.gov/pubmed/26790444)
  • 13. Subhani S, Jamil K, Nirni SS. Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy. Mol Diagn Ther 2015; 19(5): 289-97. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Subhani+S%2C+Jamil+K%2C+Nirni+SS.)
  • 14. Pongstaporn W, Pakakasama S, Chaksangchaichote P, Pongtheerat T, Hongeng S, Permitr S. MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev 2015; 16(7): 2839-43. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Pongstaporn+W%2C+Pakakasama+S%2C+Chaksangchaichote+P%2C+Pongtheerat+T%2C+Hongeng+S%2C+Permitr+S.)
  • 15. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, et al. Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene. J Pharmacol Exp Ther 2001; 297(3): 1137-43. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tanabe+M%2C+Ieiri+I%2C+Nagata+N%2C+Inoue+K%2C+Ito+S%2C+Kanamori+Y)
  • 16. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, et al. Frequency of single nucleotide polymor¬phisms in the P-glycoprotein drug transporter MDR1 gene in white sub¬jects. Clin Pharmacol Ther 2001; 69(3): 169-74. (https://www.ncbi.nlm.nih.gov/pubmed/term=Cascorbi+I%2C+Gerloff+T%2C+Johne+A%2C+Meisel+C%2C+Hoffmeyer+S%2C+Schwab+M)
  • 17. Sapmaz A, Ozen Karatayli SC, Dağli U, Kiliç ZM, Törüner M, Celik Y, et al. Effects of polymorphism in G2677T/A triallelic region of MDR1 gene in Turkish patients with inflammatory bowel disease. Turk J Gastroenterol 2008; 19(3): 168-73. (https://www.ncbi.nlm.nih.gov/pubmed/term=Sapmaz+A%2C+Ozen+Karatayli+SC%2C+Da%C4%9Fli+U%2C+Kili%C3%A7+ZM%2C+T%C3%B6r%C3%BCner+M%2C+Celik+Y)
  • 18. Fang Y, Zhao Q, Ma G, Han Y, Lou N. Investigation on MDR1 gene polymorphisms and its relationship with breast cancer risk factors in Chinese women. Med Oncol 2013; 30(1): 375. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Fang+Y%2C+Zhao+Q%2C+Ma+G%2C+Han+Y%2C+Lou+N)
  • 19. Lu PH, Wei MX, Yang J, Liu X, Tao GQ, Shen W, et al. Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat 2011; 125(2): 537-43. (https://www.ncbi.nlm.nih.gov/pubmed/term=Lu+PH%2C+Wei+MX%2C+Yang+J%2C+Liu+X%2C+Tao+GQ%2C+Shen+W)
  • 20. Wang J, Wang B, Bi J, Li K, Di J. MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies. J Cancer Res Clin Oncol 2012; 138(6): 979-89. (https://www.ncbi.nlm.nih.gov/pubmed/22358302)
  • 21. Wang LH, Song YB, Zheng WL, Jiang L, Ma WL. The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 case-control studies. Cancer Cell Int 2013;13(1):46. (https://www.ncbi.nlm.nih.gov/pubmed/term=Wang+LH%2C+Song+YB%2C+Zheng+WL%2C+Jiang+L%2C+Ma+WL)
  • 22. Ghafouri H, Ghaderi B, Amini S, Nikkhoo B, Abdi M, Hoseini A. Association of ABCB1 and ABCG2 single nucleotide polymorphisms with clinical findings and response to chemotherapy treatments in Kurdish patients with breast cancer. Tumour Biol 2016; 37(6): 7901-6. (https://www.ncbi.nlm.nih.gov/pubmed/term=Ghafouri+H%2C+Ghaderi+B%2C+Amini+S%2C+Nikkhoo+B%2C+Abdi+M%2C+Hoseini+A)
  • 23. Macías-Gómez NM, Gutiérrez-Angulo M, Leal-Ugarte E, Ramírez-Reyes L, Peregrina-Sandoval J, Meza-Espinoza JP, et al. MDR1 C3435T polymorphism in Mexican patients with breast cancer. Genet Mol Res 2014; 13(3): 5018-24. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Mac%C3%ADas-G%C3%B3mez+NM%2C+Guti%C3%A9rrez-Angulo+M%2C+Leal-Ugarte+E%2C+Ram%C3%ADrez-Reyes+L%2C+Peregrina-Sandoval+J%2C+Meza-Espinoza+JP)
  • 24. Gutierrez-Rubio SA, Quintero-Ramos A, Durán-Cárdenas A, Franco-Topete RA, Castro-Cervantes JM, Oceguera-Villanueva A, et al. 1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients. Genet Mol Res 2015; 14(1): 1250-9. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Gutierrez-Rubio+SA%2C+Quintero-Ramos+A%2C+Dur%C3%A1n C%C3%A1rdenas+A%2C+Franco-Topete+RA%2C+Castro-Cervantes+JM%2C+Oceguera-Villanueva+A)
  • 25. Tazzite A, Kassogue Y, Diakité B, Jouhadi H, Dehbi H, Benider A, et al. Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis. BMC Genet 2016; 17(1): 126. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tazzite+A%2C+Kassogue+Y%2C+Diakit%C3%A9+B%2C+Jouhadi+H%2C+Dehbi+H%2C+Benider+A)

Türk kadınlarında MDR1 (ABCB1) geni C3435T, C1236T, G2677T/A, A2956G polimorfizmleri ile meme kanseri riski arasındaki ilişki

Year 2020, Volume: 27 Issue: 3, 345 - 352, 01.09.2020
https://doi.org/10.17343/sdutfd.650471

Abstract

Amaç:
Meme kanseri dünya genelinde kadınlarda en yaygın rastlanan kanser türüdür.
Farklı populasyonlarda yapılan daha önceki çalışmalarda MDR1 geni polimorfizmleri
ile kadınlarda meme kanseri riski arasında ilişki olduğu öne sürülmüştür.
Mevcut çalışmanın amacı Türk kadınlarında MDR1 geni C3435T, G2677A/T, C1236T,
A2956G polimorfizmleri ile meme kanseri riski arasındaki ilişkiyi
araştırmaktır.



Yöntem: Bu
çalışmaya 35 meme kanseri hastası ve 20 sağlıklı kontrol dahil edilmiştir. MDR1
genotiplerinin belirlenmesi amacıyla polimeraz zincir reaksiyonu/restriksiyon
uzunluk polimorfizmi (PCR/RFLP) yöntemi kullanılmıştır.



Bulgular: Olgu
ve kontrol grubu arasında C3435T polimorfizminin genotipleri açısından anlamlı
bir fark gözlenmiştir (olgu grubu, CC %37.1, CT %28.6 ve TT %34.3; kontrol
grubu CC %25, CT %65, TT %10, p: 0.023). Diğer taraftan, C1236T ve G2677A/T
polimorfizmlerinin genotip ve allel sıklıkları gruplar arasında farklı
bulunmamıştır. A2956G polimorfizmi için ise tüm çalışma grubunun AA genotipini
taşıdığı belirlenmiştir.



Sonuç:
Çalışmamızda değerlendirilen hasta sayısı az olmakla birlikte, elde ettiğimiz
veriler MDR1 geni C3435T polimorfizminin Türk kadınlarında meme kanseri riskini
artırabileceğini düşündürmektedir. 

Project Number

Project Number: BAP08.TIP.13

References

  • 1. Yan C, Sun C, Ding X, Rizeq FK, Ren M, Yang F, et al. Association of CAV1 polymorphisms with the risks of breast cancer: A systematic review and meta-analysis. Pathol Res Pract 2019; 28: 152518. (https://www.ncbi.nlm.nih.gov/pubmed/term=Yan+C%2C+Sun+C%2C+Ding+X%2C+Rizeq+FK%2C+Ren+M%2C+Yang+F)
  • 2. Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global Cancer in Women: Burden and Trends. Cancer Epidemiol Biomarkers Prev 2017; 26(4): 444-457. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Torre+LA%2C+Islami+F%2C+Siegel+RL%2C+Ward+EM%2C+Jemal+A.)
  • 3. Özmen V. Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients). J Breast Health 2014; 10(2): 98-105. (https://www.ncbi.nlm.nih.gov/pubmed/28331652)
  • 4. Wang Z, Wang T, Bian J. Association between MDR1 C3435T polymorphism and risk of breast cancer. Gene 2013; 532(1): 94-9. (https://www.ncbi.nlm.nih.gov/pubmed/24070710)
  • 5. Gao L, Yang Y, Song S, Hong H, Zhao X, Li D. The association between genetic variant of MDR1 gene and breast cancer risk factors in Chinese women. Int Immunopharmacol 2013; 17(1): 88-91. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Gao+L%2C+Yang+Y%2C+Song+S%2C+Hong+H%2C+Zhao+X%2C+Li+D.)
  • 6. Abuhaliema AM, Yousef AM, Elmadany NN, Bulatova NR, Awwad NM, Yousef MA, et al. Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer--a Case-Control Study in Jordan. Asian Pac J Cancer Prev 2016; 17(1): 261-6. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Abuhaliema+AM%2C+Yousef+AM%2C+Elmadany+NN%2C+Bulatova+NR%2C+Awwad+NM%2C+Yousef+MA)
  • 7. Sheng X, Zhang L, Tong N, Luo D, Wang M, Xu M, et al. MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies. Mol Biol Rep 2012; 39(7): 7237-49. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Sheng+X%2C+Zhang+L%2C+Tong+N%2C+Luo+D%2C+Wang+M%2C+Xu+M%2C)
  • 8. Turgut S, Yaren A, Kursunluoglu R, Turgut G. MDR1 C3435T Polymorphism in Patients with Breast Cancer. Arch Med Res 2007; 38(5): 539-44. (https://www.ncbi.nlm.nih.gov/pubmed/17560460)
  • 9. Tatari F, Salek R, Mosaffa F, Khedri A, Behravan J. Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian population. DNA Cell Biol 2009; 28(5): 259-63. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tatari+F%2C+Salek+R%2C+Mosaffa+F%2C+Khedri+A%2C+Behravan+J.)
  • 10. Mijac D, Vukovic-Petrovic I, Mijac V, Perovic V, Milic N, Djuranovic S, et al. MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease. PLoS One 2018;13(3):e0194536. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Mijac+D%2C+Vukovic-Petrovic+I%2C+Mijac+V%2C+Perovic+V%2C+Milic+N%2C+Djuranovic+S)
  • 11. Stańko G, Kamiński M, Bogacz A, Seremak-Mrozikiewicz A, Kosiński B, Bartkowiak-Wieczorek J, et al. The importance of G2677T/A and C3435T polymorphisms of the MDR1 gene in the etiology of colorectal cancer. Prz Gastroenterol 2016; 11(1): 35-40. (https://www.ncbi.nlm.nih.gov/pubmed/?term=11.%09Sta%C5%84ko+G%2C+Kami%C5%84ski+M%2C+Bogacz+A%2C+Seremak-Mrozikiewicz+A%2C+Kosi%C5%84ski+B%2C+Bartkowiak-Wieczorek+J)
  • 12. Yin G, Xiao Z, Ni Y, Qu X, Wu H, Lu H, et al. Association of MDR1 single-nucleotide polymorphisms and haplotype variants with multiple myeloma in Chinese Jiangsu Han population. Tumour Biol 2016; 37(7): 9549-54. (https://www.ncbi.nlm.nih.gov/pubmed/26790444)
  • 13. Subhani S, Jamil K, Nirni SS. Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy. Mol Diagn Ther 2015; 19(5): 289-97. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Subhani+S%2C+Jamil+K%2C+Nirni+SS.)
  • 14. Pongstaporn W, Pakakasama S, Chaksangchaichote P, Pongtheerat T, Hongeng S, Permitr S. MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev 2015; 16(7): 2839-43. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Pongstaporn+W%2C+Pakakasama+S%2C+Chaksangchaichote+P%2C+Pongtheerat+T%2C+Hongeng+S%2C+Permitr+S.)
  • 15. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, et al. Expression of P-glycoprotein in Human Placenta: Relation to Genetic Polymorphism of the Multidrug Resistance (MDR)-1 Gene. J Pharmacol Exp Ther 2001; 297(3): 1137-43. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tanabe+M%2C+Ieiri+I%2C+Nagata+N%2C+Inoue+K%2C+Ito+S%2C+Kanamori+Y)
  • 16. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, et al. Frequency of single nucleotide polymor¬phisms in the P-glycoprotein drug transporter MDR1 gene in white sub¬jects. Clin Pharmacol Ther 2001; 69(3): 169-74. (https://www.ncbi.nlm.nih.gov/pubmed/term=Cascorbi+I%2C+Gerloff+T%2C+Johne+A%2C+Meisel+C%2C+Hoffmeyer+S%2C+Schwab+M)
  • 17. Sapmaz A, Ozen Karatayli SC, Dağli U, Kiliç ZM, Törüner M, Celik Y, et al. Effects of polymorphism in G2677T/A triallelic region of MDR1 gene in Turkish patients with inflammatory bowel disease. Turk J Gastroenterol 2008; 19(3): 168-73. (https://www.ncbi.nlm.nih.gov/pubmed/term=Sapmaz+A%2C+Ozen+Karatayli+SC%2C+Da%C4%9Fli+U%2C+Kili%C3%A7+ZM%2C+T%C3%B6r%C3%BCner+M%2C+Celik+Y)
  • 18. Fang Y, Zhao Q, Ma G, Han Y, Lou N. Investigation on MDR1 gene polymorphisms and its relationship with breast cancer risk factors in Chinese women. Med Oncol 2013; 30(1): 375. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Fang+Y%2C+Zhao+Q%2C+Ma+G%2C+Han+Y%2C+Lou+N)
  • 19. Lu PH, Wei MX, Yang J, Liu X, Tao GQ, Shen W, et al. Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat 2011; 125(2): 537-43. (https://www.ncbi.nlm.nih.gov/pubmed/term=Lu+PH%2C+Wei+MX%2C+Yang+J%2C+Liu+X%2C+Tao+GQ%2C+Shen+W)
  • 20. Wang J, Wang B, Bi J, Li K, Di J. MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies. J Cancer Res Clin Oncol 2012; 138(6): 979-89. (https://www.ncbi.nlm.nih.gov/pubmed/22358302)
  • 21. Wang LH, Song YB, Zheng WL, Jiang L, Ma WL. The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 case-control studies. Cancer Cell Int 2013;13(1):46. (https://www.ncbi.nlm.nih.gov/pubmed/term=Wang+LH%2C+Song+YB%2C+Zheng+WL%2C+Jiang+L%2C+Ma+WL)
  • 22. Ghafouri H, Ghaderi B, Amini S, Nikkhoo B, Abdi M, Hoseini A. Association of ABCB1 and ABCG2 single nucleotide polymorphisms with clinical findings and response to chemotherapy treatments in Kurdish patients with breast cancer. Tumour Biol 2016; 37(6): 7901-6. (https://www.ncbi.nlm.nih.gov/pubmed/term=Ghafouri+H%2C+Ghaderi+B%2C+Amini+S%2C+Nikkhoo+B%2C+Abdi+M%2C+Hoseini+A)
  • 23. Macías-Gómez NM, Gutiérrez-Angulo M, Leal-Ugarte E, Ramírez-Reyes L, Peregrina-Sandoval J, Meza-Espinoza JP, et al. MDR1 C3435T polymorphism in Mexican patients with breast cancer. Genet Mol Res 2014; 13(3): 5018-24. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Mac%C3%ADas-G%C3%B3mez+NM%2C+Guti%C3%A9rrez-Angulo+M%2C+Leal-Ugarte+E%2C+Ram%C3%ADrez-Reyes+L%2C+Peregrina-Sandoval+J%2C+Meza-Espinoza+JP)
  • 24. Gutierrez-Rubio SA, Quintero-Ramos A, Durán-Cárdenas A, Franco-Topete RA, Castro-Cervantes JM, Oceguera-Villanueva A, et al. 1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients. Genet Mol Res 2015; 14(1): 1250-9. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Gutierrez-Rubio+SA%2C+Quintero-Ramos+A%2C+Dur%C3%A1n C%C3%A1rdenas+A%2C+Franco-Topete+RA%2C+Castro-Cervantes+JM%2C+Oceguera-Villanueva+A)
  • 25. Tazzite A, Kassogue Y, Diakité B, Jouhadi H, Dehbi H, Benider A, et al. Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis. BMC Genet 2016; 17(1): 126. (https://www.ncbi.nlm.nih.gov/pubmed/term=Tazzite+A%2C+Kassogue+Y%2C+Diakit%C3%A9+B%2C+Jouhadi+H%2C+Dehbi+H%2C+Benider+A)
There are 25 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Fadime Mutlu İçduygu

Hale Şamlı

Türkkan Evrensel This is me

Asuman Özgöz

Kuyaş Hekimler Öztürk This is me

Mustafa Canhoroz This is me

Adem Deligönül

Necat İmirzalıoğlu This is me

Project Number Project Number: BAP08.TIP.13
Publication Date September 1, 2020
Submission Date November 24, 2019
Acceptance Date January 21, 2020
Published in Issue Year 2020 Volume: 27 Issue: 3

Cite

Vancouver Mutlu İçduygu F, Şamlı H, Evrensel T, Özgöz A, Hekimler Öztürk K, Canhoroz M, Deligönül A, İmirzalıoğlu N. Association between MDR 1 (ABCB1) gene C3435T, C1236T, G2677T/A, A2956G polymorphisms and the risk of breast cancer among Turkish Women. Med J SDU. 2020;27(3):345-52.

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