Research Article
BibTex RIS Cite
Year 2024, Volume: 42 Issue: 2, 490 - 496, 30.04.2024

Abstract

References

  • REFERENCES
  • [1] Dini D, Hanack M. Phthalocyanines as materials for advanced technologies: Some examples. J Porphyr Phthalocya 2004;8:915933. [CrossRef]
  • [2] Dumoulin F, Durmus M, Ahsen V, Nyokong T. Synthetic pathways to water-soluble phthalocyanines and close analogs. Coord Chem Rev 2010;254:27922847. [CrossRef]
  • [3] Kılıçarslan FA, Erden İ. Synthesis, characterization and photophysical properties of europium (III) Phthalocyanines bearing [4-(thiophen-3yl)-phenoxy], Sigma J Eng Nat Sci 2017;35:2334.
  • [4] Gümrükçü G, Karaoglan GK, Erdogmus A, Gül A, Avcıata U. Photochemical, and BQ quenching properties of zinc phthalocyanines with fused or interrupted extended conjugation. J Chem 2014;2014:111. [CrossRef]
  • [5] Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems- A review (Part 1). Trop J Pharm Res 2013;12:255264. [CrossRef]
  • [6] Hunter RJ. Zeta Potential in Colloid Science: Principles and Applications. 2nd ed. New York: Academic Press; 1981.
  • [7] Fujitani T. Stability of pigment and resin dispersions in waterborne paint. Prog Org Coat 1996;29:97105. [CrossRef]
  • [8] Zhai X, Guo J, Zhang W, Yang D. Effect of zeta potential on coating morphology of SiO2-coated copper powder and conductivity of copper film. Chem Pap 2020;74:2123–2131. [CrossRef]
  • [9] Dasdan DS, Dizdar A, Karakus G. Zetasizer measurements of copolymer-drug carrier system: Poly (maleic anhydrite-co-vinyl acetate) -Acriflavine conjugate. Bulg Chem Commun 2017;49:43– 49.
  • [10] Dasdan DS, Tosun G, Karahan Y. An investigation of the pH effect on the particle size and zeta potentials of poly (ethylene glycol) and poly ethylene-block-poly (ethylene glycol) with various molecular weights. Bulg Chem Commun 2018;50:5–11.
  • [11] Güngör G, Dasdan DS, Üstün E, Şahin N. Physicochemical properties, molecular docking and global reactivity descriptors of manganese carbonyl complexes with imidazole ligands. J Indian Chem Soc 2019;96:11631168.
  • [12] Börklü BR, Dasdan DS, Karahan M. Investigation of different pHs and salt concentration effects on the stability of poly (methyl vinyl ether-co-maleic anhydride)- bovine serum albumin) bioconjugate and poly (methyl vinyl ether-co-maleic anhydride)-Cu+2-bovine serum albumin) biocomplex in aquous solutions. J Indian Chem Soc 2021;97:15.
  • [13] Dasdan DS. Investigation of stability and activity of poly (ethylene-alt-maleic anhydride) copolymer at different pHs and in simulated body fluids. Bulg Chem Commun 2021;53:471474.
  • [14] Karaoglan GK, Gumrukcu G, Koca A, Gul A, Avcıata U. Synthesis and characterization of novel soluble phthalocyanines with fused conjugated unsaturated groups. Dyes Pigments 2011;90:1120. [CrossRef]
  • [15] Wang A, Gui L, Lu S, Zhou L, Zhou J, Wei S. Tumor microenvironment-responsive charge reversal zinc phthalocyanines based on amino acids for photodynamic therapy. Dyes Pigments 2016;126:239250. [CrossRef]
  • [16] El-Nahass MM, Zeyada HM, Aziz MS, El-Ghamaz NA. Structural and optical properties of thermally evaporated zinc phthalocyanine thin films. Opt Mater 2004;27:491498. [CrossRef]
  • [17] Reichardt C, Welton T. Solvents and Solvent Effects in Organic Chemistry. 4th ed. New Jersey, USA: Wiley-VHC; 2010. [CrossRef]

Investigation of stability and activity of quaternized zinc phthalocyanine photosensitizer with fused extended conjugation in vitro conditions

Year 2024, Volume: 42 Issue: 2, 490 - 496, 30.04.2024

Abstract

Quaternized zinc phthalocyanine (QZnPc) which is water soluable is a promising candidate for photo dynamic therapy (PDT) applications. The physicochemical properties like the stability, activity, particle size, surface charge of tetrakis-(4-[(1E)-3-iminoprop-1-en-1-yl]-N,N,N-trimethylphenylammonium) phthalocyaninato zinc(II)] tetraiodide (II) quaternized zinc phthalocyanine (fused extended conjugation, QZnPc-FE) were investigated. The Zeta Potential Analyzer was used for this purpose. QZnPc-FE is freshly synthesized, water soluble quaternized zinc phthalocyanine and used as potential photosensitizer for PDT application. The stability and activity behavior of QZnPc-FE was determined in vitro conditions such as different pHs and in simulated body fluids as function of time via Zetasizer measurements and UV/VIS absorbances, respectively. Morphology of the QZnPc-FE was determined via XRD and the organic solvent effect with different polarity on QZnPc-FE was checked by UV/VIS. The optimum stability and activity conditions of QZnPc-FE in vitro conditions were deter-mined, and the obtained results showed that the studied compound can be used for medical (PDT) and pharmaceutical applications.

References

  • REFERENCES
  • [1] Dini D, Hanack M. Phthalocyanines as materials for advanced technologies: Some examples. J Porphyr Phthalocya 2004;8:915933. [CrossRef]
  • [2] Dumoulin F, Durmus M, Ahsen V, Nyokong T. Synthetic pathways to water-soluble phthalocyanines and close analogs. Coord Chem Rev 2010;254:27922847. [CrossRef]
  • [3] Kılıçarslan FA, Erden İ. Synthesis, characterization and photophysical properties of europium (III) Phthalocyanines bearing [4-(thiophen-3yl)-phenoxy], Sigma J Eng Nat Sci 2017;35:2334.
  • [4] Gümrükçü G, Karaoglan GK, Erdogmus A, Gül A, Avcıata U. Photochemical, and BQ quenching properties of zinc phthalocyanines with fused or interrupted extended conjugation. J Chem 2014;2014:111. [CrossRef]
  • [5] Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems- A review (Part 1). Trop J Pharm Res 2013;12:255264. [CrossRef]
  • [6] Hunter RJ. Zeta Potential in Colloid Science: Principles and Applications. 2nd ed. New York: Academic Press; 1981.
  • [7] Fujitani T. Stability of pigment and resin dispersions in waterborne paint. Prog Org Coat 1996;29:97105. [CrossRef]
  • [8] Zhai X, Guo J, Zhang W, Yang D. Effect of zeta potential on coating morphology of SiO2-coated copper powder and conductivity of copper film. Chem Pap 2020;74:2123–2131. [CrossRef]
  • [9] Dasdan DS, Dizdar A, Karakus G. Zetasizer measurements of copolymer-drug carrier system: Poly (maleic anhydrite-co-vinyl acetate) -Acriflavine conjugate. Bulg Chem Commun 2017;49:43– 49.
  • [10] Dasdan DS, Tosun G, Karahan Y. An investigation of the pH effect on the particle size and zeta potentials of poly (ethylene glycol) and poly ethylene-block-poly (ethylene glycol) with various molecular weights. Bulg Chem Commun 2018;50:5–11.
  • [11] Güngör G, Dasdan DS, Üstün E, Şahin N. Physicochemical properties, molecular docking and global reactivity descriptors of manganese carbonyl complexes with imidazole ligands. J Indian Chem Soc 2019;96:11631168.
  • [12] Börklü BR, Dasdan DS, Karahan M. Investigation of different pHs and salt concentration effects on the stability of poly (methyl vinyl ether-co-maleic anhydride)- bovine serum albumin) bioconjugate and poly (methyl vinyl ether-co-maleic anhydride)-Cu+2-bovine serum albumin) biocomplex in aquous solutions. J Indian Chem Soc 2021;97:15.
  • [13] Dasdan DS. Investigation of stability and activity of poly (ethylene-alt-maleic anhydride) copolymer at different pHs and in simulated body fluids. Bulg Chem Commun 2021;53:471474.
  • [14] Karaoglan GK, Gumrukcu G, Koca A, Gul A, Avcıata U. Synthesis and characterization of novel soluble phthalocyanines with fused conjugated unsaturated groups. Dyes Pigments 2011;90:1120. [CrossRef]
  • [15] Wang A, Gui L, Lu S, Zhou L, Zhou J, Wei S. Tumor microenvironment-responsive charge reversal zinc phthalocyanines based on amino acids for photodynamic therapy. Dyes Pigments 2016;126:239250. [CrossRef]
  • [16] El-Nahass MM, Zeyada HM, Aziz MS, El-Ghamaz NA. Structural and optical properties of thermally evaporated zinc phthalocyanine thin films. Opt Mater 2004;27:491498. [CrossRef]
  • [17] Reichardt C, Welton T. Solvents and Solvent Effects in Organic Chemistry. 4th ed. New Jersey, USA: Wiley-VHC; 2010. [CrossRef]
There are 18 citations in total.

Details

Primary Language English
Subjects Structural Biology, Clinical Chemistry
Journal Section Research Articles
Authors

Yeşim Karahan This is me 0000-0002-1917-3484

Gülşah Gümrükçü Köse This is me 0000-0001-7947-0432

Gülnur Keser Karaoğlan 0000-0002-1765-1630

Dolunay Şakar 0000-0003-3392-6005

Publication Date April 30, 2024
Submission Date April 11, 2022
Published in Issue Year 2024 Volume: 42 Issue: 2

Cite

Vancouver Karahan Y, Gümrükçü Köse G, Keser Karaoğlan G, Şakar D. Investigation of stability and activity of quaternized zinc phthalocyanine photosensitizer with fused extended conjugation in vitro conditions. SIGMA. 2024;42(2):490-6.

IMPORTANT NOTE: JOURNAL SUBMISSION LINK https://eds.yildiz.edu.tr/sigma/