Investigation of stability and activity of quaternized zinc phthalocyanine photosensitizer with fused extended conjugation in vitro conditions

Year 2024, Volume: 42 Issue: 2, 490 - 496, 30.04.2024

Yeşim Karahan Gülşah Gümrükçü Köse Gülnur Keser Karaoğlan , Dolunay Şakar

Abstract

Quaternized zinc phthalocyanine (QZnPc) which is water soluable is a promising candidate for photo dynamic therapy (PDT) applications. The physicochemical properties like the stability, activity, particle size, surface charge of tetrakis-(4-[(1E)-3-iminoprop-1-en-1-yl]-N,N,N-trimethylphenylammonium) phthalocyaninato zinc(II)] tetraiodide (II) quaternized zinc phthalocyanine (fused extended conjugation, QZnPc-FE) were investigated. The Zeta Potential Analyzer was used for this purpose. QZnPc-FE is freshly synthesized, water soluble quaternized zinc phthalocyanine and used as potential photosensitizer for PDT application. The stability and activity behavior of QZnPc-FE was determined in vitro conditions such as different pHs and in simulated body fluids as function of time via Zetasizer measurements and UV/VIS absorbances, respectively. Morphology of the QZnPc-FE was determined via XRD and the organic solvent effect with different polarity on QZnPc-FE was checked by UV/VIS. The optimum stability and activity conditions of QZnPc-FE in vitro conditions were deter-mined, and the obtained results showed that the studied compound can be used for medical (PDT) and pharmaceutical applications.

Keywords

Water Soluable Quaternized Zinc Phthalocyanine, Zeta Potential, Particle Size, Stability, Particle Charge; Activity

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