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Investigation of the Effect of COVID-19 on Kidney Functions

Yıl 2021, Cilt: 4 Sayı: 2, 75 - 79, 30.12.2021

Öz

2019 yılında Çin'in Wuhan kentinde ortaya çıkan ve tüm dünyayı etkisi altına alan yeni tip koronavirüs (COVID-19), esas olarak solunum sistemini etkilemektedir. Solunum sisteminin yanı sıra kliniği ağır olgularda kardiyovasküler sistem, sinir sistemi, sindirim sistemi ve böbrekler de etkilenebilmektedir. Böbrek tutulumunun patofizyolojisi kesin olarak bilinmemekle birlikte hastalarda akut böbrek hasarı (AKI) sıklıkla izlenmektedir.
Çalışmamıza 336 COVID-19 pozitif hasta dahil edilerek AKI negatif (n:299) ve AKI pozitif (n:37) olmak üzere iki gruba ayrıldı. AKI negatif grupta 196 erkek ve 103 kadın, AKI pozitif grupta 31 erkek ve 6 kadın hasta saptandı. AKI negatif grubun yaş ortalaması 56.63 ± 14.64 yıl ve AKI pozitif grubun yaş ortalaması 66.08 ± 17.81 yıl olup istatistiksel olarak anlamlı bir farklılık tespit edildi (p< 0.05). Kan parametrelerinden lenfosit sayısı, monosit sayısı, kan üre azotu, kreatinin, sodyum, potasyum, albümin, CRP, ferritin, prokalsitonin ve pro-BNP gruplar arasında istatistiksel olarak anlamlı farklılıklar gösterdi (p< 0.05).
Sonuç olarak, COVID-19 hastalarında AKI gelişiminde ileri yaş ve erkek cinsiyetin önemli olduğunu, inflamatuar parametrelerin ve klinik şiddetinin AKI gelişiminin takibinde yararlı olabileceği kanaatini taşımaktayız.

Kaynakça

  • 1. Krishnan, A., Hamilton, J. P., Alqahtani, S. A., & Woreta, T. A. (2021). COVID-19: An overview and a clinical update. World journal of clinical cases, 9(1), 8–23.
  • 2. Jain U. (2020). Effect of COVID-19 on the Organs. Cureus, 12(8), e9540.
  • 3. Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Northwell COVID-19 Research Consortium, & Northwell Nephrology COVID-19 Research Consortium (2020). Acute kidney injury in patients hospitalized with COVID-19. Kidney international, 98(1), 209–218.
  • 4. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury
  • 5. Chong, W. H., & Saha, B. K. (2021). Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). The American journal of the medical sciences, 361(3), 287–296.
  • 6. Hamming, I., Timens, W., Bulthuis, M. L., Lely, A. T., Navis, G., & van Goor, H. (2004). Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. The Journal of pathology, 203(2), 631–637.
  • 7. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., Choe, H., & Farzan, M. (2003). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426(6965), 450–454.
  • 8. Robbins-Juarez, S. Y., Qian, L., King, K. L., Stevens, J. S., Husain, S. A., Radhakrishnan, J., & Mohan, S. (2020). Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis. Kidney international reports, 5(8), 1149–1160.
  • 9. Arikan, H., Ozturk, S., Tokgoz, B., Dursun, B., Seyahi, N., Trabulus, S., et al. (2021) Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology. PLoS ONE, 16(8).
  • 10. Casas-Aparicio, G. A., León-Rodríguez, I., Alvarado-de la Barrera, C., González-Navarro, M., Peralta-Prado, A. B., Luna-Villalobos, Y., Velasco-Morales, A., Calderón-Dávila, N., Ormsby, C. E., & Ávila-Ríos, S. (2021). Acute kidney injury in patients with severe COVID-19 in Mexico. PloS one, 16(2), e0246595
  • 11. Seller-Pérez, G., Más-Font, S., Pérez-Calvo, C., Villa-Díaz, P., Celaya-López, M., & Herrera-Gutiérrez, M. E. (2016). Acute kidney injury: Renal disease in the ICU. Medicina intensiva, 40(6), 374–382
  • 12. Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Northwell COVID-19 Research Consortium, & Northwell Nephrology COVID-19 Research Consortium (2020). Acute kidney injury in patients hospitalized with COVID-19. Kidney international, 98(1), 209–218.
  • 13. Hamer, M., Kivimäki, M., Gale, C. R., & Batty, G. D. (2020). Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK. Brain, behavior, and immunity, 87, 184–187.
  • 14. Ronco, C., & Reis, T. (2020). Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nature reviews. Nephrology, 16(6), 308–310.
Yıl 2021, Cilt: 4 Sayı: 2, 75 - 79, 30.12.2021

Öz

Kaynakça

  • 1. Krishnan, A., Hamilton, J. P., Alqahtani, S. A., & Woreta, T. A. (2021). COVID-19: An overview and a clinical update. World journal of clinical cases, 9(1), 8–23.
  • 2. Jain U. (2020). Effect of COVID-19 on the Organs. Cureus, 12(8), e9540.
  • 3. Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Northwell COVID-19 Research Consortium, & Northwell Nephrology COVID-19 Research Consortium (2020). Acute kidney injury in patients hospitalized with COVID-19. Kidney international, 98(1), 209–218.
  • 4. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury
  • 5. Chong, W. H., & Saha, B. K. (2021). Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI). The American journal of the medical sciences, 361(3), 287–296.
  • 6. Hamming, I., Timens, W., Bulthuis, M. L., Lely, A. T., Navis, G., & van Goor, H. (2004). Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. The Journal of pathology, 203(2), 631–637.
  • 7. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., Choe, H., & Farzan, M. (2003). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426(6965), 450–454.
  • 8. Robbins-Juarez, S. Y., Qian, L., King, K. L., Stevens, J. S., Husain, S. A., Radhakrishnan, J., & Mohan, S. (2020). Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis. Kidney international reports, 5(8), 1149–1160.
  • 9. Arikan, H., Ozturk, S., Tokgoz, B., Dursun, B., Seyahi, N., Trabulus, S., et al. (2021) Characteristics and outcomes of acute kidney injury in hospitalized COVID-19 patients: A multicenter study by the Turkish society of nephrology. PLoS ONE, 16(8).
  • 10. Casas-Aparicio, G. A., León-Rodríguez, I., Alvarado-de la Barrera, C., González-Navarro, M., Peralta-Prado, A. B., Luna-Villalobos, Y., Velasco-Morales, A., Calderón-Dávila, N., Ormsby, C. E., & Ávila-Ríos, S. (2021). Acute kidney injury in patients with severe COVID-19 in Mexico. PloS one, 16(2), e0246595
  • 11. Seller-Pérez, G., Más-Font, S., Pérez-Calvo, C., Villa-Díaz, P., Celaya-López, M., & Herrera-Gutiérrez, M. E. (2016). Acute kidney injury: Renal disease in the ICU. Medicina intensiva, 40(6), 374–382
  • 12. Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Northwell COVID-19 Research Consortium, & Northwell Nephrology COVID-19 Research Consortium (2020). Acute kidney injury in patients hospitalized with COVID-19. Kidney international, 98(1), 209–218.
  • 13. Hamer, M., Kivimäki, M., Gale, C. R., & Batty, G. D. (2020). Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK. Brain, behavior, and immunity, 87, 184–187.
  • 14. Ronco, C., & Reis, T. (2020). Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nature reviews. Nephrology, 16(6), 308–310.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Eray Atalay 0000-0002-9700-7019

Seda Çelik 0000-0003-2055-3537

İhsan Kahraman Bu kişi benim 0000-0002-1142-105X

Yayımlanma Tarihi 30 Aralık 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 4 Sayı: 2

Kaynak Göster

APA Atalay, E., Çelik, S., & Kahraman, İ. (2021). Investigation of the Effect of COVID-19 on Kidney Functions. Dünya Sağlık Ve Tabiat Bilimleri Dergisi, 4(2), 75-79.