Hipertiroidili Sıçanlarda Uzamsal Öğrenme Performansına Cinsiyetin Etkisi

Yıl 2018, Cilt: 28 Sayı: 2, 69 - 75, 01.03.2018

Burak Tan Ercan Babur Hikmet Fırat Örnek Cem Süer Nurcan Dursun

Öz

Amaç: Gelişimsel dönemdeki hipotiroidi ve hipertiroidi gibi tiroid hormon seviyesi bozukluklarında, beyinde yapısal ve fonksiyonel değişikliklerin olduğu deneysel çalışmalarda gösterilmiştir. Bu değişikliklerin, hipokampüsün önemli rol oynadığı öğrenme ve bellek gibi bilişsel süreçlerde bozulmalara ve nörolojik bozukluklara neden olduğu bilinmektedir. Bu amaçla hipertiroidili erkek ve dişi sıçanlar arasında uzamsal öğrenme performansının araştırılması amaçlanmıştır. Gereç ve Yöntem: Hipertiroidi oluşturmak için erkek ve dişi sıçanlara 21 gün süreyle 0,2 mg/kg dozda L-Tiroksin İp olarak uygulanmıştır. Öğrenme ve bellek performansını değerlendirmek için Morris su tankı testi MST kullanılmıştır. Bulgular: Tekrarlayan ölçümlerle ANOVA testi yapıldığında cinsiyet faktörü platforma olan ortalama uzaklığı anlamlı p

Anahtar Kelimeler

Hipertiroidizm, öğrenme ve bellek, hipokampüs, morris su tankı

Kaynakça

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