Araştırma Makalesi
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Serebral Beyaz Cevherde Diffüzyon Değişiklikleri: Yaş ve Cinsiyetin Etkisi

Yıl 2021, Cilt: 3 Sayı: 3, 63 - 70, 14.10.2021

Öz

Amaç: Myelinasyon, doğumdan sonra devam eden dinamik bir süreçtir. MR görüntüleme
tekniklerinden biri olan difüzyon ağırlıklı görüntüleme (DAG) ve görünen difüzyon
katsayısının (GDK) ölçümü, normal beyin gelişimi için bir kılavuzdur. Bu çalışmanın amacı
çocuklarda normal miyelinasyon gelişiminin izlenmesinde DAG ve GDK haritalarının
rolünü göstermek ve korpus kallozum (KK) ve temporal bölgelerde (TB) GDK değerlerini
belirlemektir.

Gereç ve Yöntem: MR görüntülerinin yeniden değerlendirildiği retrospektif çalışmaya
57'si erkek toplam 112 çocuk (ortalama yaş 98 ± 52,9 ay) dahil edildi. Katılımcılar 0 ile
202 ay arasında dört yaş grubuna ayrıldı. DAG ve GDK haritaları her iki TB'de KK'nın her iki
tarafından ve parahipokampal sulkus beyaz cevherinden elde edildi. GDK değerlerinin
ortalamaları belirlendi.


Bulgular:
Yaş ilerledikçe GDK değerlerinin tüm ölçüm alanlarında düştüğü görüldü (p<
0,005). Bu değişiklik TB'nin her iki tarafında ve KK genu ve gövdenin sol yarısında
önemliydi. ADC değeri cinsiyete ve ölçülen tarafa göre değişmedi.

Sonuç: GDK değerleri yaş ilerledikçe azalmaktadır. KK ve TB'nin ADC değerleri kullanılarak beyinde normal myelinasyon gelişimi ve ergenliğin neden olduğu değişiklikler
diğer patolojilerden ayırt edilebilir.

Kaynakça

  • 1. Deoni SC, Mercure E, Blasi A et al. Mapping infant brain myelination with magnetic resonance imaging. J Neurosci 2011;31: 784-791.
  • 2. Aubert-Broche B, Fonov V, Leppert I, Pike GB, Collins DL. Human brain myelination from birth to 4.5 years. Med Image Comput Comput Assist Interv 2008;11:180-187.
  • 3. Tortori- Donati P, Biancheri R, Rossi A, Raybaud C. Pediatric neuroradiology: brain head, neck and spine. First edition. New York: Springer 2010;21-40.
  • 4. Brody BA, Kinney HC, Kloman AS, Gilles, FH. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 1987;46:283- 301.
  • 5. Hermoye L, Saint-Martin C, Guy C et al. Pediatric diffusion tensor imaging: Normal database and observation of the white matter maturation in early childhood. NeuroImage 2006;29: 493-504.
  • 6. Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 2000;21:1099-1109.
  • 7. Counsell SJ, Maalouf EF, Fletcher AM et al. MR imaging assessment of myelination in the very preterm brain. AJNR Am J Neuroradiol 2002;23:872-881.
  • 8. Ladoucer CD, Pepper JS, Crone EA, Dahl RE. White matter development in adolescence: The influence of puberty and implications for affective disorders. Dev Cogn Neurosci 2012;2:36-54.
  • 9. Girard N, Raybaud C, Du Lac P. MRI study of brain myelination. J Neuroradiol 1991;18:291-307.
  • 10. Simerly RB, Chang C, Muramatsu Swanson LW. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study. J Comp Neurol 1990; 294:76-95.
  • 11. Stanfield BB, Cowan WM. The development of the hippocampal region. In: Peters A, Jones EG, eds. Cerebral Cortex: Development and Maturation of the Cerebral Cortex. New York: Plenu 1988:7:91-131.
  • 12. Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 2000;21:1099-109.
  • 13. Bonekamp D, NagaeL M, Degaonkar M et al. Diffusion Tensor Imaging in Children and Adolescents: Reproducibility, Hemispheric, and Age-Related Differences. Neuroimage 2007;15;34: 733-742.
  • 14. Andrews TJ, Osborne MT, Does MD. Diffusion of Myelin Water. Magn Reson Med 2006;56:381-385.
  • 15. Prayer D, Prayer L. Diffusion-weighted magnetic resonance imaging of cerebral white matter development. Eur J Radiol 2003;45:235-243.
  • 16. Prunas C, Delvecchio G, Perlini C et al. Diffusion imagng study of the Corpus Callosum in bipolar disorder. Psychiatry Res Neuroimaging 2018;271:75-81.
  • 17. Genç S, Seal M, Dhollander T et al. White matter alternations at pubertal onset. Neuroimage 2017;156:286-292.
  • 18. Zhang L, Thomas KM, Davidson MC, Casey BJ, Heier LA, Ulug AM. MR quantitation of volume and diffusion changes in the developing brain. AJNR Am J Neuroradiol 2005;26:45-49.
  • 19. Giorgio A, Watkins KE, Douaud G et al. Changes in white matter microstructure during adolescence. Neuroimage 2008;39:52- 61.
  • 20. Neil JJ, Shiran SI, McKinstry RC et al. Normal brain in human newborns: apparent diffusioncoefficient and diffusion anisotropy measured by using diffusion tensor MR imaging Radiology 1998;209:57-66.
  • 21. Forbes J, Pipe G, Bird CR. Changes in brain water diffusion during the 1st year of life. Radiology 2002;222:405-409.
  • 22. Lobel O, Sedlacik J, Gullmar D, WA et al. Diffusion tensor imaging: the normal evolution of ADC, RA, FA, and eigenvalues studied in multiple anatomical regions of the brain. Neuroradiology 2009;51:253-263.
  • 23. Zhai G, Lin W, Wilber KP, Gerig G, Gilmore JH. Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 2003;229: 673- 681.
  • 24. Fadeel SRA, Montasser MM, Etaby AN, Darweesh RMA. The role of diffusion weighted magnetic resonanceimaging in assessment of normal myelination in infantile brain. Alexandria Journal of Medicine 2015;51:271-276.

Diffusion Changes in Cerebral White Matter: The Effect of Age and Gender

Yıl 2021, Cilt: 3 Sayı: 3, 63 - 70, 14.10.2021

Öz

Objective: Myelination is a dynamic process that continues after birth. One of the MR
imaging techniques diffusion-weighted imaging (DWI) and measurement of apparent
diffusion coefficient (ADC) is a guide for normal brain development. The aim of this study is
to show the role of DWI and ADC maps in monitoring the normal development of
myelination in children, and to determine ADC values in corpus callosum (CC) and
temporal regions (TL).

Material and Method: A total of 112 children (mean age 98 ±52.9 months), 57 of whom
were male, were included in the retrospective study in which MRI images were
reevaluated. Participants were divided into four age groups between 0 and 202 months.
DWI and ADC maps were obtained from both sides of CC and parahippocampal sulcus
white matter in both TL. Averages of ADC values were determined.

Results: It was found that ADC values decreased in all measurement areas as the age
progressed (p< 0.005). This change was significant on both sides of the TL and left half of
the CC genu and body. ADC value did not change according to gender and measured side.


Conclusion:
ADC values decrease with progressive increase of age. Using ADC values of
CC and TL, the development of normal myelination in the brain and changes caused by
puberty can be distinguished from other pathologies.

Kaynakça

  • 1. Deoni SC, Mercure E, Blasi A et al. Mapping infant brain myelination with magnetic resonance imaging. J Neurosci 2011;31: 784-791.
  • 2. Aubert-Broche B, Fonov V, Leppert I, Pike GB, Collins DL. Human brain myelination from birth to 4.5 years. Med Image Comput Comput Assist Interv 2008;11:180-187.
  • 3. Tortori- Donati P, Biancheri R, Rossi A, Raybaud C. Pediatric neuroradiology: brain head, neck and spine. First edition. New York: Springer 2010;21-40.
  • 4. Brody BA, Kinney HC, Kloman AS, Gilles, FH. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 1987;46:283- 301.
  • 5. Hermoye L, Saint-Martin C, Guy C et al. Pediatric diffusion tensor imaging: Normal database and observation of the white matter maturation in early childhood. NeuroImage 2006;29: 493-504.
  • 6. Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 2000;21:1099-1109.
  • 7. Counsell SJ, Maalouf EF, Fletcher AM et al. MR imaging assessment of myelination in the very preterm brain. AJNR Am J Neuroradiol 2002;23:872-881.
  • 8. Ladoucer CD, Pepper JS, Crone EA, Dahl RE. White matter development in adolescence: The influence of puberty and implications for affective disorders. Dev Cogn Neurosci 2012;2:36-54.
  • 9. Girard N, Raybaud C, Du Lac P. MRI study of brain myelination. J Neuroradiol 1991;18:291-307.
  • 10. Simerly RB, Chang C, Muramatsu Swanson LW. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study. J Comp Neurol 1990; 294:76-95.
  • 11. Stanfield BB, Cowan WM. The development of the hippocampal region. In: Peters A, Jones EG, eds. Cerebral Cortex: Development and Maturation of the Cerebral Cortex. New York: Plenu 1988:7:91-131.
  • 12. Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 2000;21:1099-109.
  • 13. Bonekamp D, NagaeL M, Degaonkar M et al. Diffusion Tensor Imaging in Children and Adolescents: Reproducibility, Hemispheric, and Age-Related Differences. Neuroimage 2007;15;34: 733-742.
  • 14. Andrews TJ, Osborne MT, Does MD. Diffusion of Myelin Water. Magn Reson Med 2006;56:381-385.
  • 15. Prayer D, Prayer L. Diffusion-weighted magnetic resonance imaging of cerebral white matter development. Eur J Radiol 2003;45:235-243.
  • 16. Prunas C, Delvecchio G, Perlini C et al. Diffusion imagng study of the Corpus Callosum in bipolar disorder. Psychiatry Res Neuroimaging 2018;271:75-81.
  • 17. Genç S, Seal M, Dhollander T et al. White matter alternations at pubertal onset. Neuroimage 2017;156:286-292.
  • 18. Zhang L, Thomas KM, Davidson MC, Casey BJ, Heier LA, Ulug AM. MR quantitation of volume and diffusion changes in the developing brain. AJNR Am J Neuroradiol 2005;26:45-49.
  • 19. Giorgio A, Watkins KE, Douaud G et al. Changes in white matter microstructure during adolescence. Neuroimage 2008;39:52- 61.
  • 20. Neil JJ, Shiran SI, McKinstry RC et al. Normal brain in human newborns: apparent diffusioncoefficient and diffusion anisotropy measured by using diffusion tensor MR imaging Radiology 1998;209:57-66.
  • 21. Forbes J, Pipe G, Bird CR. Changes in brain water diffusion during the 1st year of life. Radiology 2002;222:405-409.
  • 22. Lobel O, Sedlacik J, Gullmar D, WA et al. Diffusion tensor imaging: the normal evolution of ADC, RA, FA, and eigenvalues studied in multiple anatomical regions of the brain. Neuroradiology 2009;51:253-263.
  • 23. Zhai G, Lin W, Wilber KP, Gerig G, Gilmore JH. Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 2003;229: 673- 681.
  • 24. Fadeel SRA, Montasser MM, Etaby AN, Darweesh RMA. The role of diffusion weighted magnetic resonanceimaging in assessment of normal myelination in infantile brain. Alexandria Journal of Medicine 2015;51:271-276.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makaleleri
Yazarlar

Avni Merter Keçeli 0000-0002-9412-6733

Yayımlanma Tarihi 14 Ekim 2021
Gönderilme Tarihi 6 Nisan 2021
Kabul Tarihi 8 Haziran 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 3 Sayı: 3

Kaynak Göster

AMA Keçeli AM. Diffusion Changes in Cerebral White Matter: The Effect of Age and Gender. Hitit Medical Journal. Ekim 2021;3(3):63-70.