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Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017

Yıl 2021, Cilt: 5 Sayı: 2, 156 - 161, 27.05.2021
https://doi.org/10.30621/jbachs.855719

Öz

Purpose: The purpose of our study is to reveal the demographic features, exposure routes and reasons for exposure, clinical effects and outcomes of cardiovascular drug poisonings reported to the Dokuz Eylul University Drug and Poison Information Center (DEUDPIC) between January 2014 and December 2017.
Methods: This retrospective, descriptive, and cross-sectional study was approved by the Noninvasive Research Ethics Committee of Dokuz Eylül University School of Medicine. All data were recorded on standard data forms and then transferred to a software (Ruber, written by Engin Yildiztepe, 2007) for data analysis.
Results: There were 43 poisonings cases were reported with cardiovascular drugs. Female cases were common (60.47%). Half of the poisoning cases were toxic (51.16%). The most common reason of poisonings was intentional (81.40%). All of cases between 13-49 age group were intentional exposures. Only single substance intakes were responsible for the most of the drug exposures (62.79%). The most common agents were beta-blockers (29.85%), medicines that affect the renin-angiotensin system (23.88 %), calcium channel blockers (11.94%) and cardiac therapy drugs such as digoxin (11.94%). Clinical signs and symptoms were classified as asymptomatic (37.21%), mild (23.26%), moderate (23.26%), and severe (4.65%). Recommended treatments were observation and supportive care (46.67%), decontamination methods (44.00%) and antidote therapy (2.67%). One fatality was reported.
Conclusions: We suggest that determination of the epidemiological characteristics of cardiovascular drug exposures in our country through prospectively multi-centered studies may provide significant contributions to prevent poisonings and decrease the mortality and morbidity of the cases.

Kaynakça

  • 1Rang HP, Ritter JM, Flower RJ, Henderson G. The hearts. In: Rang HP, Ritter JM, Flower RJ, Henderson G (eds). Rang&Dale’s Pharmacology. 8th ed. China:Elsevier; 2016; 247-60.
  • Muhit MA, Rahman MO, Raihan SZ, et al. Cardiovascular disease prevalence and prescription patterns at a tertiary level hospital in Bangladesh. J Appl Pharm Sci. 2012; 2: 80-4
  • Rahman A, Raka SC, Ahmed SM. Prevalence of Cardiovascular Diseases and Prescription Patterns in A Randomly Selected Population in Bangladesh. Biomed Pharmacol J. 2017; 10: 607-13.
  • Kose MR, Başara BB, Çağlar SI,et al. General Directorate of Health Research, Republic of Turkey Ministry of Health , Health Statistic Year Book 2016: 2017. Ministry of Health Publication No: 1084.
  • Meenakshisundaram R, Cannie DE, Shankar PR, Zadeh HZ, Bajrachary O, Thirumalaikolundusubramania P. Cardiovascular Toxicity of Cardiovascular Drugs. In: Meenakshisundaram R, Thirumalaikolundusubramania P (eds). Heart and Toxins. New York: Elsevier; 2015; 225-74.
  • Gummin DD, Mowry JB, Spyker AD, Brooks DE , Fraser MO, Banner W. 2016 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th Annual Report, Clinical Toxicology. 2017; 55: 1072-1254.
  • Kalkan S, Hocaoglu N, Oransay K, Unverir P, Tuncok Y. Cardiovascular medication exposures reported to Drug and Poison Information Center (DPIC) in İzmir, Turkey: A 14 year experience. Hum Exp Toxicol. 2011; 34: 53-60.
  • Ayhan H, Ozucelik DN, Dogan H, Erdogan MO, Yigit Y. Suicidal Cardiovascular Drug Intoxication in Emergency Department. HSP. 2015; 2: 329-33.
  • Zeinvand M, Hoseini T, Rahmani A. A Clinico-Epidemiological Study on Poisonings due to Cardiovascular Drugs in Ahvaz, Iran. Asia Pac J Med Toxicol. 2017; 6: 25-8.
  • Brusin KM, Sentsov VG, Krayeva YV, Kondrashov DL, Lund C, Hovda KE. Poisonings by Cardiovascular Drugs in Yekaterinburg, Russia. Asia Pac J Med Toxicol. 2016; 5: 3-10.
  • Yürüyen G, Toprak İD, Toprak Z, et al. Choice of treatment based on Turkish hypertension consensus report: Do we follow the recommendations? Turk Kardiyol Dern Ars. 2018; 46: 25-31.
Yıl 2021, Cilt: 5 Sayı: 2, 156 - 161, 27.05.2021
https://doi.org/10.30621/jbachs.855719

Öz

Kaynakça

  • 1Rang HP, Ritter JM, Flower RJ, Henderson G. The hearts. In: Rang HP, Ritter JM, Flower RJ, Henderson G (eds). Rang&Dale’s Pharmacology. 8th ed. China:Elsevier; 2016; 247-60.
  • Muhit MA, Rahman MO, Raihan SZ, et al. Cardiovascular disease prevalence and prescription patterns at a tertiary level hospital in Bangladesh. J Appl Pharm Sci. 2012; 2: 80-4
  • Rahman A, Raka SC, Ahmed SM. Prevalence of Cardiovascular Diseases and Prescription Patterns in A Randomly Selected Population in Bangladesh. Biomed Pharmacol J. 2017; 10: 607-13.
  • Kose MR, Başara BB, Çağlar SI,et al. General Directorate of Health Research, Republic of Turkey Ministry of Health , Health Statistic Year Book 2016: 2017. Ministry of Health Publication No: 1084.
  • Meenakshisundaram R, Cannie DE, Shankar PR, Zadeh HZ, Bajrachary O, Thirumalaikolundusubramania P. Cardiovascular Toxicity of Cardiovascular Drugs. In: Meenakshisundaram R, Thirumalaikolundusubramania P (eds). Heart and Toxins. New York: Elsevier; 2015; 225-74.
  • Gummin DD, Mowry JB, Spyker AD, Brooks DE , Fraser MO, Banner W. 2016 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th Annual Report, Clinical Toxicology. 2017; 55: 1072-1254.
  • Kalkan S, Hocaoglu N, Oransay K, Unverir P, Tuncok Y. Cardiovascular medication exposures reported to Drug and Poison Information Center (DPIC) in İzmir, Turkey: A 14 year experience. Hum Exp Toxicol. 2011; 34: 53-60.
  • Ayhan H, Ozucelik DN, Dogan H, Erdogan MO, Yigit Y. Suicidal Cardiovascular Drug Intoxication in Emergency Department. HSP. 2015; 2: 329-33.
  • Zeinvand M, Hoseini T, Rahmani A. A Clinico-Epidemiological Study on Poisonings due to Cardiovascular Drugs in Ahvaz, Iran. Asia Pac J Med Toxicol. 2017; 6: 25-8.
  • Brusin KM, Sentsov VG, Krayeva YV, Kondrashov DL, Lund C, Hovda KE. Poisonings by Cardiovascular Drugs in Yekaterinburg, Russia. Asia Pac J Med Toxicol. 2016; 5: 3-10.
  • Yürüyen G, Toprak İD, Toprak Z, et al. Choice of treatment based on Turkish hypertension consensus report: Do we follow the recommendations? Turk Kardiyol Dern Ars. 2018; 46: 25-31.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

Orhan Sahin Bu kişi benim 0000-0003-1606-3164

Gamze Gökalp 0000-0001-9467-3617

Nil Hocaoglu Bu kişi benim 0000-0002-7449-6809

Engin Yıldıztepe 0000-0002-7617-4934

Şule Kalkan 0000-0002-0364-7390

Yayımlanma Tarihi 27 Mayıs 2021
Gönderilme Tarihi 7 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 2

Kaynak Göster

APA Sahin, O., Gökalp, G., Hocaoglu, N., Yıldıztepe, E., vd. (2021). Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017. Journal of Basic and Clinical Health Sciences, 5(2), 156-161. https://doi.org/10.30621/jbachs.855719
AMA Sahin O, Gökalp G, Hocaoglu N, Yıldıztepe E, Kalkan Ş. Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017. JBACHS. Mayıs 2021;5(2):156-161. doi:10.30621/jbachs.855719
Chicago Sahin, Orhan, Gamze Gökalp, Nil Hocaoglu, Engin Yıldıztepe, ve Şule Kalkan. “Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017”. Journal of Basic and Clinical Health Sciences 5, sy. 2 (Mayıs 2021): 156-61. https://doi.org/10.30621/jbachs.855719.
EndNote Sahin O, Gökalp G, Hocaoglu N, Yıldıztepe E, Kalkan Ş (01 Mayıs 2021) Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017. Journal of Basic and Clinical Health Sciences 5 2 156–161.
IEEE O. Sahin, G. Gökalp, N. Hocaoglu, E. Yıldıztepe, ve Ş. Kalkan, “Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017”, JBACHS, c. 5, sy. 2, ss. 156–161, 2021, doi: 10.30621/jbachs.855719.
ISNAD Sahin, Orhan vd. “Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017”. Journal of Basic and Clinical Health Sciences 5/2 (Mayıs 2021), 156-161. https://doi.org/10.30621/jbachs.855719.
JAMA Sahin O, Gökalp G, Hocaoglu N, Yıldıztepe E, Kalkan Ş. Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017. JBACHS. 2021;5:156–161.
MLA Sahin, Orhan vd. “Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017”. Journal of Basic and Clinical Health Sciences, c. 5, sy. 2, 2021, ss. 156-61, doi:10.30621/jbachs.855719.
Vancouver Sahin O, Gökalp G, Hocaoglu N, Yıldıztepe E, Kalkan Ş. Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017. JBACHS. 2021;5(2):156-61.