INVESTIGATION OF THE STRUCTURES OF CLINICALLY IMPORTANT CATECHOLAMINES AND THEIR DERIVATIVES

Yıl 2024, Cilt: 48 Sayı: 1, 366 - 383, 20.01.2024

Özden Tarı Mustafa Kürtül

https://doi.org/10.33483/jfpau.1369190

Öz

Objective: Dopamine, epinephrine, and norepinephrine which are derivatives of 3,4-dihydroxyphenylethylamine are endogenous compounds with very important biological roles called catecholamines, in monoamine structure. It’s known that these biomolecules carrying the catechol structure control many systems in the organism by stimulating their specific receptors. In particular, it is observed the stimulating effects of these endogenous compounds on the adrenergic and dopaminergic systems. These compounds, which are involved in many biological processes as hormones or neurotransmitters, are also obtained synthetically due to their therapeutic importance and use in the clinical. In addition, many new derivatives have been developed with chemical modifications in order to improve the pharmacological and pharmaceutical properties of endogenous catecholamines. The wide and important clinical use of these compounds makes them valuable for researchers. It’s very important with regard to the development of new derivatives, to research the activities of catecholamines and derivative compounds used in the clinical, to understand their chemical structures, and to investigate the methods of obtaining them.
Result and Discussion: Therefore in this study, the structures and properties of catecholamine derivatives with clinical significance were investigated. As a result of this study, the chemical properties, biosynthesis, and synthetically obtainment methods of catecholamines, their biological activities, and use clinically were revealed.

Anahtar Kelimeler

Adrenaline, catecholamines, dopamine, noradrenaline

KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ

Öz

Amaç: Katekolaminler olarak adlandırılan monoamin yapısındaki 3,4-dihidroksifeniletilamin türevi dopamin, epinefrin ve norepinefrin, çok önemli biyolojik rolleri olan endojen bileşiklerdir. Katekol yapısı taşıyan bu biyomoleküllerin, kendine özgü reseptörleri uyararak, organizmadaki pek çok sistemi kontrol ettiği bilinmektedir. Özellikle bu endojen bileşiklerin, adrenerjik ve dopaminerjik sistem üzerinden uyarıcı etkilerinin olduğu görülmektedir. Pek çok biyolojik süreçte hormon veya nörotransmitter olarak yer alan bu bileşikler, terapötik önemleri nedeniyle sentetik olarak da elde edilerek klinikte kullanılmaktadır. Ayrıca, endojen katekolaminlerin farmakolojik ve farmasötik özelliklerini iyileştirmek amacıyla, kimyasal modifikasyonlar ile yeni pek çok türevi geliştirilmiştir. Klinikteki kullanımlarının geniş ve önemli olması, bu bileşikleri araştırmacılar için değerli kılmaktadır. Katekolamin ve türevi bileşiklerin aktivitelerinin incelenmesi kadar kimyasal yapılarının anlaşılması ve sentez yöntemlerinin araştırılması da yeni türevlerin geliştirilmesi açısından çok önemlidir.
Sonuç ve Tartışma: Bu nedenle bu çalışmada klinik önemleri olan katekolamin türevlerinin yapıları ve özellikleri araştırılmıştır. Çalışma sonucunda katekolaminlerin kimyasal özellikleri, biyosentezleri ve sentetik olarak elde edilme yöntemleri ile biyolojik aktiviteleri ve klinikteki kullanımları ortaya konulmuştur.

Anahtar Kelimeler

Adrenalin, dopamin, katekolaminler, noradrenalin

Kaynakça

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