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INVESTIGATION OF THE STRUCTURES OF CLINICALLY IMPORTANT CATECHOLAMINES AND THEIR DERIVATIVES

Yıl 2024, Cilt: 48 Sayı: 1, 366 - 383, 20.01.2024
https://doi.org/10.33483/jfpau.1369190

Öz

Objective: Dopamine, epinephrine, and norepinephrine which are derivatives of 3,4-dihydroxyphenylethylamine are endogenous compounds with very important biological roles called catecholamines, in monoamine structure. It’s known that these biomolecules carrying the catechol structure control many systems in the organism by stimulating their specific receptors. In particular, it is observed the stimulating effects of these endogenous compounds on the adrenergic and dopaminergic systems. These compounds, which are involved in many biological processes as hormones or neurotransmitters, are also obtained synthetically due to their therapeutic importance and use in the clinical. In addition, many new derivatives have been developed with chemical modifications in order to improve the pharmacological and pharmaceutical properties of endogenous catecholamines. The wide and important clinical use of these compounds makes them valuable for researchers. It’s very important with regard to the development of new derivatives, to research the activities of catecholamines and derivative compounds used in the clinical, to understand their chemical structures, and to investigate the methods of obtaining them.
Result and Discussion: Therefore in this study, the structures and properties of catecholamine derivatives with clinical significance were investigated. As a result of this study, the chemical properties, biosynthesis, and synthetically obtainment methods of catecholamines, their biological activities, and use clinically were revealed.

Kaynakça

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KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ

Yıl 2024, Cilt: 48 Sayı: 1, 366 - 383, 20.01.2024
https://doi.org/10.33483/jfpau.1369190

Öz

Amaç: Katekolaminler olarak adlandırılan monoamin yapısındaki 3,4-dihidroksifeniletilamin türevi dopamin, epinefrin ve norepinefrin, çok önemli biyolojik rolleri olan endojen bileşiklerdir. Katekol yapısı taşıyan bu biyomoleküllerin, kendine özgü reseptörleri uyararak, organizmadaki pek çok sistemi kontrol ettiği bilinmektedir. Özellikle bu endojen bileşiklerin, adrenerjik ve dopaminerjik sistem üzerinden uyarıcı etkilerinin olduğu görülmektedir. Pek çok biyolojik süreçte hormon veya nörotransmitter olarak yer alan bu bileşikler, terapötik önemleri nedeniyle sentetik olarak da elde edilerek klinikte kullanılmaktadır. Ayrıca, endojen katekolaminlerin farmakolojik ve farmasötik özelliklerini iyileştirmek amacıyla, kimyasal modifikasyonlar ile yeni pek çok türevi geliştirilmiştir. Klinikteki kullanımlarının geniş ve önemli olması, bu bileşikleri araştırmacılar için değerli kılmaktadır. Katekolamin ve türevi bileşiklerin aktivitelerinin incelenmesi kadar kimyasal yapılarının anlaşılması ve sentez yöntemlerinin araştırılması da yeni türevlerin geliştirilmesi açısından çok önemlidir.
Sonuç ve Tartışma: Bu nedenle bu çalışmada klinik önemleri olan katekolamin türevlerinin yapıları ve özellikleri araştırılmıştır. Çalışma sonucunda katekolaminlerin kimyasal özellikleri, biyosentezleri ve sentetik olarak elde edilme yöntemleri ile biyolojik aktiviteleri ve klinikteki kullanımları ortaya konulmuştur.

Kaynakça

  • 1. Nikolajsen, R.P.H., Hansen, A.M. (2001). Analytical methods for determining urinary catecholamines in healthy subjects. Analytica Chimica Acta, 449, 1-15. [CrossRef]
  • 2. Nagatsu, T. (1973). Biochemistry of Catecholamines; the Biochemical Method, University Park Press, Baltimore, p. 362.
  • 3. Doğan, P. (2005). Katekolamin biosentezi ve metabolik etkileri. Türkiye Klinikleri Dahili Tıp Bilimleri Dergisi, 1(3), 88-92.
  • 4. Clark, C.R., Geffen, G.M., Geffen, L.B. (1987). Catecholamines and attention II: Pharmacological studies inormal humans. Neuroscience and Biobehavioral Reviews, 4, 353-364. [CrossRef]
  • 5. Vieira, I.C., Fatibello-Filho, O. (1998). Spectrophotometric determination of methyldopa and dopamine in pharmaceutical formulations using a crude extract of sweet potato root (Ipomoea batatas (L.) Lam.) as enzymatic source. Talanta, 46(4), 559-564. [CrossRef]
  • 6. Mete, S. Ders notu, Otonom Sinir Sistemine Giriş, Nevşehir Üniversitesi. Web site. Erişim adresi https://sistem.nevsehir.edu.tr/bizdosyalar/c2f433923e6615b388e1cca9a9777378/TTP%20Farmakoloji%202-Otonom%20sininr%20sistemi.pdf. Erişim tarihi: 04.05.2023.
  • 7. Drugbank, Norepinefrin Web site. Erişim adresi https://go.drugbank.com/drugs/DB00368. Erişim tarihi: 04.05.2023.
  • 8. Hardman, J.G., Limbird, L.E., Gilman, A.G. (2006). Goodman ve Gilman´s The Pharmacological Basis of Therapeutics, 11th ed, New York, p. 249.
  • 9. Drugbank, Epinefrin Web site. Erişim adresi https://go.drugbank.com/drugs/DB00668. Erişim tarihi: 04.05.2023.
  • 10. Eczacıbaşı İlaç Pazarlama, Norepinefrin için Kısa Ürün Bilgisi Web site. Erişim adresi: https://www.eczacibasiilac.com.tr/EIP/media/EIP_Media/PDF/Stenor_4m_4ml_IV_Ampul_KUB.pdf. Erişim tarihi: 04.05.2023.
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  • 12. Bethesda, M.D. (2006). Phenylephrine. National Institute of Child Health and Human Development National Library of Medicine, Drugs and Lactation Database (LactMed) from https://www.ncbi.nlm.nih.gov/books/NBK501438/. Erişim tarihi: 04.05.2023.
  • 13. Cooper, B.E. (2008). Review and update on inotropes and vasopressors. Advanced Critical Care, 19(1), 5-13.
  • 14. Mercier, F.J, Auge, M., Hoffmann, C., Fischer, C., Le Gouez, A. (2013). Maternal hypotension during spinal anesthesia for caesarean delivery. Minerva Anestesiologica, 79(1), 62-73.
  • 15. Price, A.H., Clissold, S.P. (2012). Salbutamol in the 1980s. A reappraisal of its clinical efficacy. Drugs, 38(1), 77-122. [CrossRef]
  • 16. Sultan, K., Zamir, A., Ashraf, W., Imran, I., Saeed, H., Rehman, A.U., Majeed, A., Rasool, M.F. (2023). Clinical pharmacokinetics of terbutaline in humans: A systematic review. Naunyn-Schmiedeberg's Archives of Pharmacology, 396(2), 213-227. [CrossRef]
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  • 24. Blanco, A., Blanco, G. (2017). Medical Biochemistry. 1st ed, Academic Press, Elsevier Science. p.110.
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Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık Bilimleri
Bölüm Derleme
Yazarlar

Özden TARI 0000-0001-9280-6594

Mustafa KÜRTÜL 0000-0002-9580-3871

Erken Görünüm Tarihi 30 Kasım 2023
Yayımlanma Tarihi 20 Ocak 2024
Gönderilme Tarihi 30 Eylül 2023
Kabul Tarihi 9 Kasım 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 48 Sayı: 1

Kaynak Göster

APA TARI, Ö., & KÜRTÜL, M. (2024). KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ. Journal of Faculty of Pharmacy of Ankara University, 48(1), 366-383. https://doi.org/10.33483/jfpau.1369190
AMA TARI Ö, KÜRTÜL M. KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ. Ankara Ecz. Fak. Derg. Ocak 2024;48(1):366-383. doi:10.33483/jfpau.1369190
Chicago TARI, Özden, ve Mustafa KÜRTÜL. “KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 1 (Ocak 2024): 366-83. https://doi.org/10.33483/jfpau.1369190.
EndNote TARI Ö, KÜRTÜL M (01 Ocak 2024) KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ. Journal of Faculty of Pharmacy of Ankara University 48 1 366–383.
IEEE Ö. TARI ve M. KÜRTÜL, “KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ”, Ankara Ecz. Fak. Derg., c. 48, sy. 1, ss. 366–383, 2024, doi: 10.33483/jfpau.1369190.
ISNAD TARI, Özden - KÜRTÜL, Mustafa. “KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ”. Journal of Faculty of Pharmacy of Ankara University 48/1 (Ocak 2024), 366-383. https://doi.org/10.33483/jfpau.1369190.
JAMA TARI Ö, KÜRTÜL M. KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ. Ankara Ecz. Fak. Derg. 2024;48:366–383.
MLA TARI, Özden ve Mustafa KÜRTÜL. “KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 1, 2024, ss. 366-83, doi:10.33483/jfpau.1369190.
Vancouver TARI Ö, KÜRTÜL M. KLİNİKTE ÖNEMLİ OLAN KATEKOLAMİN VE TÜREVLERİNİN YAPILARININ İNCELENMESİ. Ankara Ecz. Fak. Derg. 2024;48(1):366-83.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.