Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41
was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO2)
environment. 2-chloro-benzoythiourea modified MCM-41 was prepared
and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections
observed at low angle XRD show the mesoporous SiO2 structure. The
paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET
surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m2/g
2-chloro-benzoythiourea
modified MCM-4, respectively. The absorption and
releasing studies of ibuprofen were caried out in simulated body fluid. The
result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea
modified MCM-41 and slower drug release rate was achieved.
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 15 Mayıs 2019 |
Gönderilme Tarihi | 4 Ekim 2018 |
Kabul Tarihi | 18 Ocak 2019 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 6 Sayı: 1 |