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Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Yıl 2017, Cilt: 39 Sayı: 1, 109 - 116, 15.03.2017
https://doi.org/10.20515/otd.287890

Öz

Notch
sinyal yolağı, gelişim döneminde hücre kaderinin belirlenmesinde rol oynayan
bir mekanizmadır. Notch reseptörü boyunca komşu hücreler arasındaki sinyal
alışverişi artar. Notch aktivitesi organ oluşumu ve morfogenezde rol oynayarak
farklılaşma, çoğalma ve apoptozu etkiler. Son çalışmalar Notch sinyalinin hücre
farklılaşması ve proliferasyonu ile apoptotik olaylarda rol oynadığını kanıtlanmıştır.
Ayrıca kanserli hücrelerde Notch aktivasyonunun anormal hücre çoğalmasına neden
olduğu görülmüştür. Notch ile hücre çoğalması arasında önemli bir bağlantı
olduğu birçok çalışmada gösterilmiştir. Bu derlemede Notch sinyal yolağı
elementleri, aktivasyonu ve kanseri hangi mekanizmalarla etkilediği ele
alınmaktadır.

Kaynakça

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  • Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999). Notch signaling: cell fate control and signal integration in development. Science, 284(5415), 770-776.
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  • Beverly, L. J., Felsher, D. W., & Capobianco, A. J. (2005). Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer research, 65(16), 7159-7168.
  • Boggs, K., Henderson, B., & Reisman, D. (2009). RBP‐Jκ binds to and represses transcription of the p53 tumor suppressor gene. Cell biology international, 33(3), 318-324.
  • Brzozowa-Zasada, M., Piecuch, A., Dittfeld, A., Mielańczyk, Ł., Michalski, M., Wyrobiec, G., ... & Wojnicz, R. (2016). Notch signalling pathway as an oncogenic factor involved in cancer development. Contemp Oncol (Pozn), 20(4), 267-272.
  • Cheng, P., Zlobin, A., Volgina, V., Gottipati, S., Osborne, B., Simel, E. J., Gabrilovich, D. I. (2001). Notch-1 regulates NF-κB activity in hemopoietic progenitor cells. The Journal of Immunology, 167(8), 4458-4467.
  • Dallman, M. J., Smith, E., Benson, R. A., & Lamb, J. R. (2005). Notch: control of lymphocyte differentiation in the periphery. Current opinion in immunology, 17(3), 259-266.
  • Dang, T. P. (2012). Notch, apoptosis and cancer Notch Signaling in Embryology and Cancer (pp. 199-209): Springer.
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  • Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res 19(8):1972–1980.
  • Hassan WA, Yoshida R, Kudoh S, Hasegawa K, Niimori-Kita K, Ito T (2014) Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines. Lung Cancer 86(3):304–310.
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  • Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP (2007) Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 67(17):8051–8057.
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Toplam 38 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm DERLEMELER / REVIEWS
Yazarlar

Emine Yağcı

Hasan Veysi Güneş

Yayımlanma Tarihi 15 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 39 Sayı: 1

Kaynak Göster

Vancouver Yağcı E, Güneş HV. Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi. 2017;39(1):109-16.


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