Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Yıl 2017, Cilt: 39 Sayı: 1, 109 - 116, 15.03.2017

Emine Yağcı , Hasan Veysi Güneş

https://doi.org/10.20515/otd.287890

Öz

Notch
sinyal yolağı, gelişim döneminde hücre kaderinin belirlenmesinde rol oynayan
bir mekanizmadır. Notch reseptörü boyunca komşu hücreler arasındaki sinyal
alışverişi artar. Notch aktivitesi organ oluşumu ve morfogenezde rol oynayarak
farklılaşma, çoğalma ve apoptozu etkiler. Son çalışmalar Notch sinyalinin hücre
farklılaşması ve proliferasyonu ile apoptotik olaylarda rol oynadığını kanıtlanmıştır.
Ayrıca kanserli hücrelerde Notch aktivasyonunun anormal hücre çoğalmasına neden
olduğu görülmüştür. Notch ile hücre çoğalması arasında önemli bir bağlantı
olduğu birçok çalışmada gösterilmiştir. Bu derlemede Notch sinyal yolağı
elementleri, aktivasyonu ve kanseri hangi mekanizmalarla etkilediği ele
alınmaktadır.

Anahtar Kelimeler

Notch sinyal yolağı, Kanser, Apoptoz

Kaynakça

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