KANTİTATİF TAYİNDE YEŞİL YÖNTEM:ATR-FTIR; FARMASÖTİK PREPARATTA PARASETAMOL TAYİNİ

Yıl 2023, Cilt: 22 Sayı: 44, 425 - 433, 31.12.2023

Nükte Topraksever Gamze Özgül Artuç

https://doi.org/10.55071/ticaretfbd.1375697

Öz

Bu çalışmada azaltılmış toplam yansıma Fourier dönüşümlü kızıl ötesi (ATR-FTIR) spektroskopisi kullanılarak farmasötik preparatta parasetamol tayin edilmiştir. Parasetamol standart konsantrasyonları NaCl ile seyreltilerek % 20 ile % 100 (a/a) arasında hazırlanmıştır. Parasetamol standardının FTIR spektrumu alınarak karakteristik C=O pikinin değişen yüzde geçirgenliği kullanılarak kalibrasyon eğrisi çizilmiştir. Regresyon katsayısı (R2) 0.9993 ile iyi bir doğrusallık göstermiştir. Parasetamol içeren ticari farmasötik preparattaki miktar tayini yapılmıştır. Farmasötik preparattaki parasetamol miktar tayininin geri kazanımı  % 100’dür. Farmasötik preparata uygulanan ATR-FTIR yöntemi parasetamolün rutin tayini için uygundur.

Anahtar Kelimeler

ATR-FTIR, Farmasötik preparat, Parasetamol, Yeşil Kimya

GREEN METHOD FOR QUANTITATIVE DETERMINATION: ATR-FTIR; DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL PREPARATION

Öz

In this study, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy was used for the determination of paracetamol in pharmaceutical preparation. Paracetamol standard concentrations were prepared between 20% and 100% (w/w) by dilution with NaCl. The FTIR spectrum of the paracetamol standard was taken and the calibration curve was plotted using the varying percentage transmittance of the characteristic C=O peak. This curve showed good linearity with a regression coefficient (R2) of 0,9993. Quantification was carried out in commercial pharmaceutical preparation containing paracetamol. The recovery of the quantification of paracetamol in pharmaceutical preparation is  100%. The ATR-FTIR method applied to pharmaceutical preparation is suitable for the routine determination of paracetamol.

Anahtar Kelimeler

ATR-FTIR, Pharmaceutical preparation, Paracetamol, Green Chemistry

Kaynakça

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