BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI

Yıl 2017, Cilt: 22 Sayı: 3, 127 - 144, 28.12.2017

Şerife Şafak Esra Karaca

https://doi.org/10.17482/uumfd.309657

Cited By: 1

Öz

Polisakkarit esaslı polimerler,
biyomedikal uygulamalarda yaygın olarak kullanılmaktadır. Bu çalışmada; polisakkarit
hyaluronik asit, karboksimetil selüloz ve sodyum alginat polimerleri
kullanılarak elektro çekim yöntemiyle nanolifli yüzey üretimi gerçekleştirilmiştir.
Üretilen nanolifli yüzeye, suya dayanımını geliştirmek amacıyla, 1-etil-3-(3-dimetilaminopropil) karbodiimid hidroklorit ve N-hidroksisülfosüksinimit
karışımı
ile çapraz bağlama işlemi uygulanmıştır. Nanolifli yüzey, çapraz bağlama işlemi
öncesi ve sonrasında, taramalı elektron mikroskobu, fourier transform infrared
spektrometresi, atomik kuvvet mikroskobu, BET analizi ve suya dayanım testi ile
karakterize edilmiştir. Sonuçlar; çapraz bağlama işlemi ile lifli yapının
deformasyona uğramadan nanolifli yüzeyin suya dayanıklı hale geldiğini
göstermiştir.

Anahtar Kelimeler

Hyaluronik asit, karboksimetil selüloz, sodyum alginat, nanolif, elektro çekim

Production and Crosslinking of Polysaccharide Based Nanofibrous Mat for Biomedical Applications

Öz

Polysaccharide based polymers are widely used in
biomedical applications. In this study, nanofibrous mat was produced from
hyaluronic acid, carboxymethyl cellulose and sodium alginate polysaccharide polymers
via electrospinning method. Resultant nanofibrous mat was crosslinked with 1-etil-3-(3-dimethylaminopropyl)
carbodiimide hydrochloride and N-hydroxysulfosuccinimide
solution to develop its water resistance. Before and after the crosslinking
process, nanofibrous mat was characterized by scanning electron microscope,
fourier transform infrared spectrometry, atomic force microscope, BET analysis and
water resistance test. The results
indicated that the nanofibrous mat was become resistant to water without any
deformation of nanofibrous structure with the crosslinking application.

Anahtar Kelimeler

Hyaluronic acid, carboxymethyl cellulose, alginate, nanofiber, eelctrospinning, crosslinking

Kaynakça

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