Year 2018, Volume 18, Issue 2, Pages 451 - 457 2018-08-31

Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives

Kıymet BERKİL AKAR [1] , Hasan KILINÇ [2]

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Novel bromo- and O/S-substituted-1,4-naphthoquninones (3a-3i) were synthesized via nucleophilic substitution reactions from 2,5,8-tribromo-1,4-naphthoquinone (1). Antimicrobial evaluation of the newly synthesized derivatives was performed using agar spot method. Compounds 3a, 3b, and 3c exhibited the greatest activity with MIC value of 61,25 μg/mL against P. vulgaris, B. cereus and B.subutilis, and B.cereus, respectively. Results revealed that compound 3c has notable activity against all tested microorganisms.
1, 4-Naphthoquinone, Nucleophilic substitution, Antimicrobial activity
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Primary Language en
Journal Section Articles
Authors

Author: Kıymet BERKİL AKAR

Author: Hasan KILINÇ

Bibtex @research article { akufemubid539252, journal = {Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi}, issn = {}, eissn = {2149-3367}, address = {Afyon Kocatepe University}, year = {2018}, volume = {18}, pages = {451 - 457}, doi = {}, title = {Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives}, key = {cite}, author = {BERKİL AKAR, Kıymet and KILINÇ, Hasan} }
APA BERKİL AKAR, K , KILINÇ, H . (2018). Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 18 (2), 451-457. Retrieved from http://dergipark.org.tr/akufemubid/issue/43970/539252
MLA BERKİL AKAR, K , KILINÇ, H . "Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives". Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18 (2018): 451-457 <http://dergipark.org.tr/akufemubid/issue/43970/539252>
Chicago BERKİL AKAR, K , KILINÇ, H . "Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives". Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18 (2018): 451-457
RIS TY - JOUR T1 - Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives AU - Kıymet BERKİL AKAR , Hasan KILINÇ Y1 - 2018 PY - 2018 N1 - DO - T2 - Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi JF - Journal JO - JOR SP - 451 EP - 457 VL - 18 IS - 2 SN - -2149-3367 M3 - UR - Y2 - 2018 ER -
EndNote %0 Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives %A Kıymet BERKİL AKAR , Hasan KILINÇ %T Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives %D 2018 %J Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi %P -2149-3367 %V 18 %N 2 %R %U
ISNAD BERKİL AKAR, Kıymet , KILINÇ, Hasan . "Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/S-substituted-1,4-naphthoquinone Derivatives". Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18 / 2 (August 2018): 451-457.