The influence of helicobacter pylori eradication on serum oxidized low density lipoprotein in patients with functional dyspepsia

- , 01.03.2019

Muammer Bilici Yasin Öztürk Başak Delikanlı Çorakçı İshak Özel Tekin Selim Aydemir

https://doi.org/10.16919/bozoktip.454052

Öz

Objectives: Since its discovery, Helicobacter pylori (H. pylori)
have been implicated in the pathogenesis of several diseases located both in
the digestive and extradigestive systems. Interestingly, the majority of the
literature on extradigestive-related disease mainly focuses on ischemic heart
disease. Oxidized low-density lipoprotein (ox-LDL) is an important key point in
the progression of atherogenesis. The aim of the present study was to
investigate whether the eradication of H. pylori infection affects serum ox-LDL
levels.

Methods: A total of 73 patients with H. Pylori–associated
dyspepsia and 23 controls were included in this study. Bismuth quadruple
therapy was given for 14 days. Serum levels of ox-LDL, LDL and high-density
lipoprotein (HDL) were measured at baseline and 8 weeks after therapy.
Successful eradication was proven with the 14C-urea breath test.

Results: There were no significant differences in terms of
age and gender between the patients and controls (p=0.066 and p = 0.475,
respectively). Comparing H. Pylori patients to healthy controls with respect to
serum ox-LDL and LDL levels were significantly higher in the patient group
(p=0.04 and p=0.046 respectively). It was noticed that oxLDL levels were lower
in eradicated patients with no correctable risk factors for cardiovascular
disease after therapy (p=0.047). However, there was no statistically
significant difference in serum ox-LDL levels between baseline and after
therapy among the other patients (p>0.05).

Conclusion: The findings of our study might indicate that H.
pylori eradication influences the oxidation of LDL. However, the role of H.
pylori infection on atherosclerosis progression is a controversial issue.

Anahtar Kelimeler

Helicobacter pylori; Atherosclerosis; Oxidized LDL

FONKSİYONEL DİSPEPSİLİ HASTALARDA HELİKOBAKTER PİLORİ ERADİKASYONUNUN SERUM OKSİDE LDL DÜZEYLERİ ÜZERİNE ETKİLERİ

Öz

Amaç:
Helicobacter pylori (H. pylori), ilk keşfinden itibaren sindirim sistemi ve
diğer sistemlerle ilgili bir çok hastalığın patogenezinde yer almakla
suçlanmıştır. İlginç olarak, sindirim sistemi dışı hastalıklarla
ilgili literatürün çoğunluğu, özellikle iskemik kalp hastalığına odaklanmıştır.
Aterosklerozun
ilerlemesinde oksitlenmiş düşük
yoğunluklu lipoprotein (ox-LDL) önemli bir rol oynamaktadır. Bu
çalışmada, H. pylori eradikasyonunun serum ox-LDL düzeyleri üzerine etkisini
değerlendirmek amaçlanmıştır.

Yöntem:
Çalışmaya H. pylori ile ilişkili dispepsisi olan 73 hasta ve 23 sağlıklı
gönüllü kontrol grubu olarak dahil edildi. Hastalara bizmut içeren dörtlü
tedavi 14 gün süreyle verildi. Serum ox-LDL, LDL ve yüksek yoğunluklu
lipoprotein (HDL) düzeyleri tedaviden önce ve 8 hafta sonra olmak üzere
ölçüldü. H. pylori eradikasyonu 14C-üre nefes testi ile doğrulandı. Analiz
sonuçlarının istatiksel analizleri SPSS 13.0 bilgisayar proğramı ile yapıldı.

Bulgular:
Hasta ve kontrol grubu arasında yaş ve cinsiyet açısından anlamlı fark
bulunmadı (sırasıyla p = 0,066 ve p = 0,475). Hastalarda serum ox-LDL ve LDL
düzeyleri sağlıklı kontrollere göre anlamlı olarak yüksek bulundu (sırasıyla p
= 0,04 ve p = 0,046). Düzeltilebilir kardiyovasküler hastalık risk faktörü taşımayanlarda
eradikasyon başarısı sonrası ox-LDL düzeylerinde anlamlı azalma saptandı (p =
0.047). Ancak, diğer hastalar arasında tedavi öncesi ve sonrası serum ox-LDL
düzeylerinde istatistiksel olarak anlamlı bir fark yoktu (p> 0.05).

Sonuç: H. pylori ilişkili dispepsi hastalarında
eradikasyon tedavisinin ateroskleroz progresyonuna sınırlıda olsa yararlı
etkisi olduğu kanaatindeyiz.

Anahtar Kelimeler

Helicobacter pylori; Ateroskleroz; oksitlenmiş LDL

Kaynakça

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