Year 2019, Volume 7, Issue 3, Pages 1237 - 1248 2019-07-31

Comparison of Crosslinker Types and Initiation Systems of Thermoresponsive PNIPAM Hydrogels
Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması

Pinar Cakir Hatir [1] , Ozlem Yalcin Capan [2]

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Thermoresponsive hydrogels are three-dimensional polymer networks which undergo conformational changes in aqueous media depending on the external temperature. As the lower critical temperature (LCST) is close to the body temperature, poly(N-isopropylacrylamide) (PNIPAM) is the main thermoresponsive hydrogel used for biomedical applications. Below LCST, PNIPAM hydrogels swell in aqueous media, above LCST they become insoluble and shrink. This behavior makes it possible to design drug release systems controlled by external temperature. Swelling/shrinking response of PNIPAM hydrogel depends on several factors such as crosslinker type, crosslinking density, hydrophobic/hydrophilic balance and initiator type. In this study, the effects of the initiation system and the crosslinker type on different thermoresponsive hydrogels were compared. For this purpose, thermoresponsive hydrogels were synthesized by using ethylene glycol dimethylacrylate (EGDMA) and N,N′-ethylene bisacrylamide (EBAM) as crosslinkers via photo and thermal initiation systems. The hydrogels were characterized by scanning electron microscope (SEM) and FTIR spectroscopy. Effects of the initiation system and the crosslinker type on the release, swelling behavior, morphology and the biocompatibility behavior of the hydrogels were investigated. The hydrogels synthesized with EBAM demonstrated more promising results compared to the one synthesized EGDMA. It was concluded that poly(EBAM-co-NIPAM)-P has the highest swelling ratio and poly(EBAM-co-NIPAM)-T is the most biocompatible hydrogel. In terms of release characteristics, there was not a significant difference between the hydrogels, even though their swelling characteristics differ.

Thermoresponsive hydrogels are three-dimensional polymer networks which undergo conformational changes in aqueous media depending on the external temperature. As the lower critical temperature (LCST) is close to the body temperature, poly(N-isopropylacrylamide) (PNIPAM) is the main thermoresponsive hydrogel used for biomedical applications. Below LCST, PNIPAM hydrogels swell in aqueous media, above LCST they become insoluble and shrink. This behavior makes it possible to design drug release systems controlled by external temperature. Swelling/shrinking response of PNIPAM hydrogel depends on several factors such as crosslinker type, crosslinking density, hydrophobic/hydrophilic balance and initiator type. In this study, the effects of the initiation system and the crosslinker type on different thermoresponsive hydrogels were compared. For this purpose, thermoresponsive hydrogels were synthesized by using ethylene glycol dimethylacrylate (EGDMA) and N,N′-ethylene bisacrylamide (EBAM) as crosslinkers via photo and thermal initiation systems. The hydrogels were characterized by FTIR spectroscopy and scanning electron microscope (SEM). Effects of the initiation system and the crosslinker type on the release, swelling behavior, morphology and the biocompatibility behavior of the hydrogels were investigated. The hydrogels synthesized with EBAM demonstrated more promising results compared to the one synthesized EGDMA. It was concluded that poly(EBAM-co-NIPAM)-P has the highest swelling ratio and poly(EBAM-co-NIPAM)-T is the most biocompatible hydrogel. In terms of release characteristics, there was not a significant difference between the hydrogels, even though their swelling characteristics differ.

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Primary Language en
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0002-3806-7118
Author: Pinar Cakir Hatir (Primary Author)
Institution: ISTANBUL AREL UNIVERSITY
Country: Turkey


Orcid: 0000-0002-7511-3355
Author: Ozlem Yalcin Capan
Institution: ISTANBUL AREL UNIVERSITY
Country: Turkey


Dates

Publication Date: July 31, 2019

Bibtex @research article { dubited544824, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {Duzce University}, year = {2019}, volume = {7}, pages = {1237 - 1248}, doi = {10.29130/dubited.544824}, title = {Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması}, key = {cite}, author = {Cakir Hatir, Pinar and Yalcin Capan, Ozlem} }
APA Cakir Hatir, P , Yalcin Capan, O . (2019). Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 7 (3), 1237-1248. DOI: 10.29130/dubited.544824
MLA Cakir Hatir, P , Yalcin Capan, O . "Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1237-1248 <http://dergipark.org.tr/dubited/issue/46290/544824>
Chicago Cakir Hatir, P , Yalcin Capan, O . "Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1237-1248
RIS TY - JOUR T1 - Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması AU - Pinar Cakir Hatir , Ozlem Yalcin Capan Y1 - 2019 PY - 2019 N1 - doi: 10.29130/dubited.544824 DO - 10.29130/dubited.544824 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 1237 EP - 1248 VL - 7 IS - 3 SN - -2148-2446 M3 - doi: 10.29130/dubited.544824 UR - https://doi.org/10.29130/dubited.544824 Y2 - 2019 ER -
EndNote %0 Duzce University Journal of Science and Technology Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması %A Pinar Cakir Hatir , Ozlem Yalcin Capan %T Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması %D 2019 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 7 %N 3 %R doi: 10.29130/dubited.544824 %U 10.29130/dubited.544824
ISNAD Cakir Hatir, Pinar , Yalcin Capan, Ozlem . "Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 / 3 (July 2019): 1237-1248. https://doi.org/10.29130/dubited.544824
AMA Cakir Hatir P , Yalcin Capan O . Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması. DUBİTED. 2019; 7(3): 1237-1248.
Vancouver Cakir Hatir P , Yalcin Capan O . Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2019; 7(3): 1248-1237.