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Hormone Levels in Male Cases With Behcet's Disease

Year 2023, , 200 - 206, 29.12.2023
https://doi.org/10.47493/abantmedj.1349095

Abstract

Objective: Behcet's disease (BD) is a chronic relapsing systemic inflammatory disease with no clear etiopathogenesis. Because the disease usually starts during the sexually active period and shows a more severe course in males, we aimed to evaluate the hypothalamo-hypophyseal-gonadal axis in male patients.
Materials and Methods: Our study included 25 male patients with Behcet's disease and 22 healthy males. In accordance with our purpose, patients and healthy participants were stimulated with gonadotropin releasing hormone (GnRH) followed by examination of the blood for sex hormone binding globulin (SHBG), cortisol, estradiol, free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), and follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels. The results were compared between the groups.
Results: Estradiol levels were significantly higher in the patient group (36.80±14.70 pg/ml) compared to the control group (29.30±9.15 pg/ml) (p=0.045). Conversely, DHEA levels were significantly lower in patient group (13.74±7.96 ng/ml) than in control group (18.36±7.12 ng/ml) (p=0.043). Levels of the other hormones did not show any significant difference between the groups.
Conclusion: In order to better evaluate the roles of hormones and the hypothalamo-hypophyseal-gonadal axis in relation to the etiopathogenesis of BD, there is a need for larger scale studies, which also take into account disease activity.

References

  • Alpsoy E, Leccese P, Ergun T. Editorial: Behçet’s Disease: Epidemiology, etiopathogenesis, diagnosis and treatment. Front Med (Lausanne). 2021; Nov 5:8.
  • Boyvat A. Behçet hastalığının etyopatogenezi. Turk Klin J Dermatol 2004; 4:15-21.
  • International Study Group for Behcet’s Disease. Criteria for diagnosis of Behcet’s disease. Lancet 1990; 335:1078–80.
  • Alpsoy E, Akman A. Behçet Hastalığı: Etyopatogenezde yeni kavramlar. Türk Klin J Int Med Sci 2007; 3:8-14.
  • Odabaş AR, Çetinkaya R, Karakuzu A, Selçuk Y, Çapoğlu İ. Erkek aktif behçet hastalarında serum seks hormon düzeyleri. AÜTD 2000; 32:149-151.
  • Gül Ü, Bayram F, Küçükterzi V, Gürsoy G, İkinci G. Behçet hastalığında endokrin fonksiyonlar. Turk Klin J Dermatol 1996; 6:62-64.
  • Cutulo M, Sulli A, Capellino S, Villaggio B, Montagna P, Serolo B, et al. Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 2004; 13:635-8
  • Buendia-Gonzalez FO, Legorreta-Herrera M. The similarities and differences between the effects of testosterone and DHEA on the innate and adaptive immune response. Biomolecules. 2022; 2712(12):1768.
  • Alpsoy E, Elpek GO, Yilmaz F, Ciftcioglu MA, Akman A, Uzun S, Karakuzu A. Androgen receptor levels of oral and genital ulcers and skin pathergy test in patients with Behcet’s disease. Dermatology 2005; 210:31-35.
  • Yavuz S, Özilhan G, Elbir Y, Tolunay A, Demiralp EE, Direskeneli H. Activation of neutrophils by testosterone in Behçet’s disease. Clin Exp Rheumatol 2007; 25 (Suppl 45):46-51.
  • Miyamoto N, Mandai M, Suzuma I, Suzuma K, Kobayashi K, Honda Y. Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis. J Immunol 1999; 163:374-379.
  • Buyon JP, Korchak HM, Rutherford LE, Ganguly M, Weissman G. Female hormones reduce neutrophil responsiveness in vitro. Arthritis Rheum 1984; 27:623-630.
  • Çolak R, Özkan Y, Cengiz SU, Saral Y, Kandi BC, Halifeoğlu I. A comparison between the effects of low (1μg) and standar dose (250μg) ACTH stimulation tests on adrenal cortex functions with Behçet’s disease. J Eur Acad Dermatol Venereol 2006; 20:721-725.
  • Richter JG, Becker A, Specker C, Schneider M. Hypogonadism in Wegener’s granulomatosis. Scand J Rheumatol 2008; 37:365-369.
  • Karakus S, Nar A, Toprak SK, Atalay F, Ozcebe OI. An evaluation of hormone levels in Behçet's disease. Turk J Rheumatol 2012; 27(3):158-164.
  • Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin and autoimmunity: The hormone as an inflammatory cytokine. Best Pract Res Clin Endocrinol Metab. 2019 Dec; 33(6):101324
  • Atasoy M, Karatay S, Yıldırım K, Kadi M, Erdem T, Senel K. The relationship between serum prolactin levels and disease activity in patients with Behcet’s disease. Cell Biochem Funct 2006; 24:353-356.
  • Avci A, Avci D. Serum prolactin levels in Behçet's disease. Is there a relationship between Behcet's disease and prolactin as in other autoimmune diseases? Acta Dermatovenerol Croat. 2013; 21(1):52-3.
  • Song GG, Lee YH. Circulating prolactin levels and Behcet’s disease: A meta-analysis. Cell Mol Biol. 2018 Jan 31; 64(1):14-18.

Erkek Behçet Hastalarında Hormon Düzeyleri

Year 2023, , 200 - 206, 29.12.2023
https://doi.org/10.47493/abantmedj.1349095

Abstract

Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük.
Gereç ve Yöntemler: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı.
Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu.
Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.

References

  • Alpsoy E, Leccese P, Ergun T. Editorial: Behçet’s Disease: Epidemiology, etiopathogenesis, diagnosis and treatment. Front Med (Lausanne). 2021; Nov 5:8.
  • Boyvat A. Behçet hastalığının etyopatogenezi. Turk Klin J Dermatol 2004; 4:15-21.
  • International Study Group for Behcet’s Disease. Criteria for diagnosis of Behcet’s disease. Lancet 1990; 335:1078–80.
  • Alpsoy E, Akman A. Behçet Hastalığı: Etyopatogenezde yeni kavramlar. Türk Klin J Int Med Sci 2007; 3:8-14.
  • Odabaş AR, Çetinkaya R, Karakuzu A, Selçuk Y, Çapoğlu İ. Erkek aktif behçet hastalarında serum seks hormon düzeyleri. AÜTD 2000; 32:149-151.
  • Gül Ü, Bayram F, Küçükterzi V, Gürsoy G, İkinci G. Behçet hastalığında endokrin fonksiyonlar. Turk Klin J Dermatol 1996; 6:62-64.
  • Cutulo M, Sulli A, Capellino S, Villaggio B, Montagna P, Serolo B, et al. Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 2004; 13:635-8
  • Buendia-Gonzalez FO, Legorreta-Herrera M. The similarities and differences between the effects of testosterone and DHEA on the innate and adaptive immune response. Biomolecules. 2022; 2712(12):1768.
  • Alpsoy E, Elpek GO, Yilmaz F, Ciftcioglu MA, Akman A, Uzun S, Karakuzu A. Androgen receptor levels of oral and genital ulcers and skin pathergy test in patients with Behcet’s disease. Dermatology 2005; 210:31-35.
  • Yavuz S, Özilhan G, Elbir Y, Tolunay A, Demiralp EE, Direskeneli H. Activation of neutrophils by testosterone in Behçet’s disease. Clin Exp Rheumatol 2007; 25 (Suppl 45):46-51.
  • Miyamoto N, Mandai M, Suzuma I, Suzuma K, Kobayashi K, Honda Y. Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis. J Immunol 1999; 163:374-379.
  • Buyon JP, Korchak HM, Rutherford LE, Ganguly M, Weissman G. Female hormones reduce neutrophil responsiveness in vitro. Arthritis Rheum 1984; 27:623-630.
  • Çolak R, Özkan Y, Cengiz SU, Saral Y, Kandi BC, Halifeoğlu I. A comparison between the effects of low (1μg) and standar dose (250μg) ACTH stimulation tests on adrenal cortex functions with Behçet’s disease. J Eur Acad Dermatol Venereol 2006; 20:721-725.
  • Richter JG, Becker A, Specker C, Schneider M. Hypogonadism in Wegener’s granulomatosis. Scand J Rheumatol 2008; 37:365-369.
  • Karakus S, Nar A, Toprak SK, Atalay F, Ozcebe OI. An evaluation of hormone levels in Behçet's disease. Turk J Rheumatol 2012; 27(3):158-164.
  • Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin and autoimmunity: The hormone as an inflammatory cytokine. Best Pract Res Clin Endocrinol Metab. 2019 Dec; 33(6):101324
  • Atasoy M, Karatay S, Yıldırım K, Kadi M, Erdem T, Senel K. The relationship between serum prolactin levels and disease activity in patients with Behcet’s disease. Cell Biochem Funct 2006; 24:353-356.
  • Avci A, Avci D. Serum prolactin levels in Behçet's disease. Is there a relationship between Behcet's disease and prolactin as in other autoimmune diseases? Acta Dermatovenerol Croat. 2013; 21(1):52-3.
  • Song GG, Lee YH. Circulating prolactin levels and Behcet’s disease: A meta-analysis. Cell Mol Biol. 2018 Jan 31; 64(1):14-18.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Dermatology
Journal Section Research Articles
Authors

Tuna Sezer 0000-0002-6861-2869

Hilmi Cevdet Altınyazar 0000-0002-7105-2938

Rafet Koca 0000-0003-1546-5380

Nilgün Solak Tekin 0000-0002-6572-9615

Saniye Çınar 0000-0003-2041-5097

Early Pub Date December 11, 2023
Publication Date December 29, 2023
Submission Date August 24, 2023
Published in Issue Year 2023

Cite

APA Sezer, T., Altınyazar, H. C., Koca, R., Solak Tekin, N., et al. (2023). Erkek Behçet Hastalarında Hormon Düzeyleri. Abant Medical Journal, 12(3), 200-206. https://doi.org/10.47493/abantmedj.1349095
AMA Sezer T, Altınyazar HC, Koca R, Solak Tekin N, Çınar S. Erkek Behçet Hastalarında Hormon Düzeyleri. Abant Med J. December 2023;12(3):200-206. doi:10.47493/abantmedj.1349095
Chicago Sezer, Tuna, Hilmi Cevdet Altınyazar, Rafet Koca, Nilgün Solak Tekin, and Saniye Çınar. “Erkek Behçet Hastalarında Hormon Düzeyleri”. Abant Medical Journal 12, no. 3 (December 2023): 200-206. https://doi.org/10.47493/abantmedj.1349095.
EndNote Sezer T, Altınyazar HC, Koca R, Solak Tekin N, Çınar S (December 1, 2023) Erkek Behçet Hastalarında Hormon Düzeyleri. Abant Medical Journal 12 3 200–206.
IEEE T. Sezer, H. C. Altınyazar, R. Koca, N. Solak Tekin, and S. Çınar, “Erkek Behçet Hastalarında Hormon Düzeyleri”, Abant Med J, vol. 12, no. 3, pp. 200–206, 2023, doi: 10.47493/abantmedj.1349095.
ISNAD Sezer, Tuna et al. “Erkek Behçet Hastalarında Hormon Düzeyleri”. Abant Medical Journal 12/3 (December 2023), 200-206. https://doi.org/10.47493/abantmedj.1349095.
JAMA Sezer T, Altınyazar HC, Koca R, Solak Tekin N, Çınar S. Erkek Behçet Hastalarında Hormon Düzeyleri. Abant Med J. 2023;12:200–206.
MLA Sezer, Tuna et al. “Erkek Behçet Hastalarında Hormon Düzeyleri”. Abant Medical Journal, vol. 12, no. 3, 2023, pp. 200-6, doi:10.47493/abantmedj.1349095.
Vancouver Sezer T, Altınyazar HC, Koca R, Solak Tekin N, Çınar S. Erkek Behçet Hastalarında Hormon Düzeyleri. Abant Med J. 2023;12(3):200-6.