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Evaluation of Varicella Complications

Year 2015, , 360 - 365, 01.11.2015
https://doi.org/10.5505/abantmedj.2015.67699

Abstract

OBJECTIVE: In this retrospective study of childhood, we aimed to evaluate the varicella complications of the acute phase, the distribution according to the season and the clinical characteristics of complications.METHODS: This study was carried out in Tepecik Training and Research Hospital and 228 patients who were hospitalised due to varicella complications within seven years period were included. Varicella infection was diagnosed clinically. Complications included all varicella-related events requiring hospitalization. Cases were investigated according to months and seasons that varicella is common.RESULTS: The mean age of the patients was 3.49±2.92 years 1 month-14 years . Within the study group, 77 33.7% had pneumonia, 29 12.7% of them had febrile seizures, 28 12.2% of them had bacterial skin superinfection, 22 9.6% of them had upper respiratory tract infections, 22 9.6% of them had menigoensefalit, 15 %6.5 of them had acute cerebellar ataxia, 46 20.1% of them had thrombocytopenia and %3.9 of them were sever, 46 20.1% of them had elevated liver enzymes, 15 6.5% of them had leukopenia, 7 3.0% of them had dehydration, 2 0.6% of them had diarrhea, 1 0.3% of them had bullous varicella. In addition, 8 3.5% patients were admitted to hospital for observation because of persistent fever. Pneumonia is the most common complications under 2 years of age. Febrile convulsions were particularly observed during the first 3 days after the onset of the rash. The patients were seen most frequently in January and the second most common in June.CONCLUSION: These findings suggest that varicella causes more serious problems in healthy children that they could even be considered and vaccination is the most important primary prevention method.

References

  • 1. Kanra G, Kara A. Varisella zoster virus enfeksiyonları. Çocuk Sağlığı ve Hastalıkları Dergisi 2002; 45: 260-74.
  • 2. Gershon AA. Varicella zoster virus infections,. In: Gershon AA HP, Katz SL, (Eds). Krugman’s Infectious Diseases of Children. Mosby, Philadelphia 2004: 785-816.
  • 3. Prevention of varicella: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR Recomm Rep. 1996; 45: 1-36.
  • 4. Maharshak N, Somekh E. Hospitalization for varicella in central Israel. Acta Paediatr 1999; 88: 1279-83.
  • 5. Peterson CL, Mascola L, Chao SM, Lieberman JM, Arcinue EL, Blumberg DA, et al. Children hospitalized for varicella: a prevaccine review. J Pediatr 1996; 129: 529-36.
  • 6. Jaeggi A, Zurbruegg RP, Aebi C. Complications of varicella in a defined central European population. Arch Dis Child 1998; 79: 472-7.
  • 7. Dinleyici EC, Kurugol Z, Turel O, Hatipoglu N, Devrim I, Agin H, et al. The epidemiology and economic impact of varicella-related hospitalizations in Turkey from 2008 to 2010: a nationwide survey during the pre-vaccine era (VARICOMP study). Eur J Pediatr 2012; 171: 817-25.
  • 8. Peyramond D, Chidiac C, Lucht F, Perronne C, Saimot AG, Soussy JC, et al. Management of infections due to the varicella-zoster virus. 11th consensus conference on anti-infectious therapy of the French-speaking Society of Infectious Diseases (SPILF). Eur J Dermatol 1998; 8: 397-402.
  • 9. Vugia DJ, Peterson CL, Meyers HB, Kim KS, Arrieta A, Schlievert PM, et al. Invasive group A streptococcal infections in children with varicella in Southern California. Pediatr Infect Dis J 1996; 15: 146-50. 10. Merlin E, Souteyrand G, Dauphin C, Lusson RJ, De Riberolles C, Poirier V, et al. [Streptococcus pyogenes endocarditis following varicella: a case report]. Arch Pediatr 2004; 11: 122-5.
  • 11. Gilden D. Varicella zoster virus and central nervous system syndromes. Herpes 2004; 11 Suppl 2: 89A-94A.
  • 12. Echevarria JM, Casas I, Martinez-Martin P. Infections of the nervous system caused by varicella-zoster virus: a review. Intervirology 1997; 40: 72-84.
  • 13. Tseng HW, Liu CC, Wang SM, Yang YJ, Huang YS. Complications of varicella in children: emphasis on skin and central nervous system disorders. J Microbiol Immunol Infect 2000; 33: 248-52.
  • 14. Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura. Transfus Sci 1998; 19: 253-9.
  • 15. Fleisher G, Henry W, McSorley M, Arbeter A, Plotkin S. Life-threatening complications of varicella. Am J Dis Child 1981; 135: 896-9.

Suçiçeği Komplikasyonlarının Değerlendirilmesi

Year 2015, , 360 - 365, 01.11.2015
https://doi.org/10.5505/abantmedj.2015.67699

Abstract

AMAÇ: Bu çalışmada retrospektif olarak çocukluk çağında, suçiçeği enfeksiyonunun akut döneminde görülen komplikasyonlarının, mevsimlere göre dağılımı, komplikasyonların klinik özelliklerinin saptanması amaçlandı.YÖNTEMLER: Bu çalışmada 7 yıl süre ile Tepecik Eğitim Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Klinikleri Çocuk Enfeksiyon Servisine suçiçeği komplikasyonları nedeniyle yatırılan öncesinde kronik hastalığı ve immün süpresyonu bulunmayan 228 hasta değerlendirildi. Suçiçeği tanısı klinik olarak konuldu. Komplikasyonlar yatışı gerektiren bütün suçiçeği ile ilgili olayları kapsadı. Olguların sık görüldüğü aylar ve mevsimler incelendi.BULGULAR: Olguların yaş ortalaması 3.49 ± 2.92 yıl olup 1 ay – 14 yaş idi. Yetmiş yedi %33.7 olguda pnömoni, 29 %12.7 olguda febril konvülziyon, 28 %12.2 olguda bakteriyel cilt süperenfeksiyonu, 22 %9.6 olguda üst solunum yolu enfeksiyonu, 22 %9.6 olguda menigoensefalit, 15 %6.5 olguda akut sereballar ataksi, 9’u %3.9 ciddi olmak üzere 46 %20.1 olguda trombositopeni, 46 %20.1 olguda karaciğer transaminazlarında artma, 15 %6.5 olguda lökopeni, 7 %3.0 olguda dehidratasyon, 2 %0.6 olguda diyare, 1 %0.3 olguda büllöz varisella, saptandı. Ayrıca 8 %3.5 olgu dirençli ateş nedeniyle gözlem amacıyla hastaneye yatırıldı. En sık görülen komplikasyon pnömoni olup 2 yaş altında sık olarak saptandı. Febril konvüzyon özellikle döküntünün başlamasından ilk 3 gün içinde izlendi. Olgular en sık olarak ocak ve ikinci sıklıkta haziran ayında görüldü. SONUÇ: Bu bulgular suçiçeğinin günümüzde sağlıklı çocuklar için dahi düşünülenden daha ciddi sorunlar oluşturabildiğinin, her zaman selim bir hastalık olmadığının göstergesidir ve aşı en önemli birincil korunma yöntemidir.

References

  • 1. Kanra G, Kara A. Varisella zoster virus enfeksiyonları. Çocuk Sağlığı ve Hastalıkları Dergisi 2002; 45: 260-74.
  • 2. Gershon AA. Varicella zoster virus infections,. In: Gershon AA HP, Katz SL, (Eds). Krugman’s Infectious Diseases of Children. Mosby, Philadelphia 2004: 785-816.
  • 3. Prevention of varicella: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR Recomm Rep. 1996; 45: 1-36.
  • 4. Maharshak N, Somekh E. Hospitalization for varicella in central Israel. Acta Paediatr 1999; 88: 1279-83.
  • 5. Peterson CL, Mascola L, Chao SM, Lieberman JM, Arcinue EL, Blumberg DA, et al. Children hospitalized for varicella: a prevaccine review. J Pediatr 1996; 129: 529-36.
  • 6. Jaeggi A, Zurbruegg RP, Aebi C. Complications of varicella in a defined central European population. Arch Dis Child 1998; 79: 472-7.
  • 7. Dinleyici EC, Kurugol Z, Turel O, Hatipoglu N, Devrim I, Agin H, et al. The epidemiology and economic impact of varicella-related hospitalizations in Turkey from 2008 to 2010: a nationwide survey during the pre-vaccine era (VARICOMP study). Eur J Pediatr 2012; 171: 817-25.
  • 8. Peyramond D, Chidiac C, Lucht F, Perronne C, Saimot AG, Soussy JC, et al. Management of infections due to the varicella-zoster virus. 11th consensus conference on anti-infectious therapy of the French-speaking Society of Infectious Diseases (SPILF). Eur J Dermatol 1998; 8: 397-402.
  • 9. Vugia DJ, Peterson CL, Meyers HB, Kim KS, Arrieta A, Schlievert PM, et al. Invasive group A streptococcal infections in children with varicella in Southern California. Pediatr Infect Dis J 1996; 15: 146-50. 10. Merlin E, Souteyrand G, Dauphin C, Lusson RJ, De Riberolles C, Poirier V, et al. [Streptococcus pyogenes endocarditis following varicella: a case report]. Arch Pediatr 2004; 11: 122-5.
  • 11. Gilden D. Varicella zoster virus and central nervous system syndromes. Herpes 2004; 11 Suppl 2: 89A-94A.
  • 12. Echevarria JM, Casas I, Martinez-Martin P. Infections of the nervous system caused by varicella-zoster virus: a review. Intervirology 1997; 40: 72-84.
  • 13. Tseng HW, Liu CC, Wang SM, Yang YJ, Huang YS. Complications of varicella in children: emphasis on skin and central nervous system disorders. J Microbiol Immunol Infect 2000; 33: 248-52.
  • 14. Rand ML, Wright JF. Virus-associated idiopathic thrombocytopenic purpura. Transfus Sci 1998; 19: 253-9.
  • 15. Fleisher G, Henry W, McSorley M, Arbeter A, Plotkin S. Life-threatening complications of varicella. Am J Dis Child 1981; 135: 896-9.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Mustafa Dilek This is me

Mehmet Helvacı This is me

Nejat Aksu This is me

Publication Date November 1, 2015
Published in Issue Year 2015

Cite

APA Dilek, M., Helvacı, M., & Aksu, N. (2015). Suçiçeği Komplikasyonlarının Değerlendirilmesi. Abant Medical Journal, 4(4), 360-365. https://doi.org/10.5505/abantmedj.2015.67699
AMA Dilek M, Helvacı M, Aksu N. Suçiçeği Komplikasyonlarının Değerlendirilmesi. Abant Med J. November 2015;4(4):360-365. doi:10.5505/abantmedj.2015.67699
Chicago Dilek, Mustafa, Mehmet Helvacı, and Nejat Aksu. “Suçiçeği Komplikasyonlarının Değerlendirilmesi”. Abant Medical Journal 4, no. 4 (November 2015): 360-65. https://doi.org/10.5505/abantmedj.2015.67699.
EndNote Dilek M, Helvacı M, Aksu N (November 1, 2015) Suçiçeği Komplikasyonlarının Değerlendirilmesi. Abant Medical Journal 4 4 360–365.
IEEE M. Dilek, M. Helvacı, and N. Aksu, “Suçiçeği Komplikasyonlarının Değerlendirilmesi”, Abant Med J, vol. 4, no. 4, pp. 360–365, 2015, doi: 10.5505/abantmedj.2015.67699.
ISNAD Dilek, Mustafa et al. “Suçiçeği Komplikasyonlarının Değerlendirilmesi”. Abant Medical Journal 4/4 (November 2015), 360-365. https://doi.org/10.5505/abantmedj.2015.67699.
JAMA Dilek M, Helvacı M, Aksu N. Suçiçeği Komplikasyonlarının Değerlendirilmesi. Abant Med J. 2015;4:360–365.
MLA Dilek, Mustafa et al. “Suçiçeği Komplikasyonlarının Değerlendirilmesi”. Abant Medical Journal, vol. 4, no. 4, 2015, pp. 360-5, doi:10.5505/abantmedj.2015.67699.
Vancouver Dilek M, Helvacı M, Aksu N. Suçiçeği Komplikasyonlarının Değerlendirilmesi. Abant Med J. 2015;4(4):360-5.