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Relationship between periodontal diseases and serum lipid levels in patients undergoing peritoneal dialysis and hemodialysis

Year 2014, , 128 - 133, 01.05.2014
https://doi.org/10.5505/abantmedj.2014.50570

Abstract

OBJECTIVE: The aim of this study was to evaluate in association between periodontal diseases and serum total cholesterol TC , triglyceride, low density lipoprotein LDL and high density lipoprotein HDL levels in patients undergoing peritoneal dialysis or hemodialysis treatment.METHODS: 40 hemodialysis HD and 54 peritoneal dialysis PD patients were included in the study. Groups divided into three subgroups as healthy, gingivitis and periodontitis. Decayed, missing, filled teeth index DMFT scores and fasting venous blood samples were obtained from all of the subjects. RESULTS: Significant differences in age, gender and DMFT scores p>0.05 were not observed. HDL, LDL and TC levels were significantly higher in PD group than HD group p0.05 . There were no significantly difference in the serum TC, Triglyceride, LDL, HDL and CRP levels in each subgroups of PD group p>0.05 . There were no significantly difference in the serum TC, Triglyceride, LDL, HDL and CRP levels in each subgroups of HD group p>0.05 .CONCLUSION: The results indicate that there is no significant association between periodontal diseases and serum lipid levels in dialysis patients.

References

  • 1. Craig RG. Interactions between chronic renal disease and periodontal disease. Oral Dis 2008;14:1- 7.
  • 2. Gudapati A, Ahmed P, Rada R. Dental management of patients with renal failure. Gen Dent 2002;50:508-10.
  • 3. Craig RG, Spittle MA, Levin NW. Importance of periodontal disease in the kidney patient. Blood Purif 2002;20:113-9.
  • 4. Kotanko P. Chronic inflammation in dialysis patients - periodontal disease, the new kid on the block. Oral Dis;2008:14:8-9.
  • 5. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997;350:430-6.
  • 6. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366: 1809-20.
  • 7. D'Aiuto F, Ready D, Tonetti MS. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res 2004;39:236-41.
  • 8. Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim BO, Nares S, Iacopino AM. Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 1999;70:1429-34.
  • 9. Losche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000; 27:537-41.
  • 10. Fentoglu O, Oz G, Tasdelen P, Uskun E, Aykac Y, Bozkurt FY. Periodontal status in subjects with hyperlipidemia. J Periodontol 2009;80:267-73.
  • 11. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Ann Periodontol 2003;8 54-69.
  • 12. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003;8:38-53.
  • 13. Bots CP, Poorterman JH, Brand HS, Kalsbeek H, van Amerongen BM, Veerman EC, Nieuw Amerongen AV. The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy. Oral Dis 2006;12:176-80.
  • 14. Cengiz MI, Bal S, Gokcay S, Cengiz K. Does periodontal disease reflect atherosclerosis in continuous ambulatory peritoneal dialysis patients? J Periodontol 2007;78:1926-34.
  • 15. Bayraktar G, Kurtulus I, Kazancioglu R, Bayramgurler I, Cintan S, Bural C, Bozfakioglu S, Besler M, Trablus S, Issever H, Yildiz A. Evaluation of periodontal parameters in patients undergoing peritoneal dialysis or hemodialysis. Oral Dis 2008; 14:185- 9.
  • 16. Clark DB. Dental findings in patients with chronic renal failure. An overview. J Can Dent Assoc 1987;53:781-5.
  • 17. Silness J, Loe H. Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand 1964;22:121-35.
  • 18. Loe H, Silness J. Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontol Scand, 1963;21:533-51.
  • 19. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
  • 20. Noack B, Jachmann I, Roscher S, Sieber L, Kopprasch S, Luck C, Hanefeld M, Hoffmann T. Metabolic diseases and their possible link to risk indicators of periodontitis. J Periodontol 2000;71:898-903.
  • 21. Tsumura M, Kinouchi T, Ono S, Nakajima T, Komoda T. Serum lipid metabolism abnormalities and change in lipoprotein contents in patients with advanced-stage renal disease. Clin Chim Acta 2001;314:27-37.
  • 22. Shoji T, Ishimura E, Inaba M, Tabata T, Nishizawa Y. Atherogenic lipoproteins in end-stage renal disease. Am J Kidney Dis 2001; 38:30-3.
  • 23. Chmielewski M, Carrero JJ, Nordfors L, Lindholm B, Stenvinkel P. Lipid disorders in chronic kidney disease: reverse epidemiology and therapeutic approach. J Nephrol 2008;21:635-44.
  • 24. Stenvinkel P, Heimburger O, Lindholm B, Kaysen GA, Bergstrom J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 2000;15:953-60.
  • 25. Castledine C, van Schalkwyk D, Feest T, Steenkamp R, Dawnay A. UK Renal Registry 13th Annual Report (December 2010): Chapter 10: calcium, phosphate, parathyroid hormone, bicarbonate and total cholesterol concentrations amongst patients receiving haemodialysis or peritoneal dialysis in England, Wales and Northern Ireland in 2009: nati-onal and centre-specific analyses. Nephron Clin Pract 2011;119 (Suppl 2): c179-214.
  • 26. Penumarthy S, Penmetsa GS, Mannem S. Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients. J Indian Soc Periodontol 2013;17:30-5.
  • 27. Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 2002;73:494-500.
  • 28. Fentoglu O, Koroglu BK, Hicyilmaz H, Sert T, Ozdem M, Sutcu R, Tamer MN, Orhan H, Ay ZY, Ozturk Tonguc M, Kirzioglu FY. Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. J Clin Periodontol 2011; 38: 8-16.
  • 29. Katz J, Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol 2001;28: 865-8.
  • 30. Maglakelidze N, Galogre A, Tsagareli Z. Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia. Georgian Med News 2005;121:71-4.

Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki

Year 2014, , 128 - 133, 01.05.2014
https://doi.org/10.5505/abantmedj.2014.50570

Abstract

AMAÇ: Sağlıklı bireylerde yapılan bazı çalışmalarda periodontal hastalık varlığı ile serum lipid değerleri arasında anlamlı bir ilişki olduğu gösterilmiştir. Ancak böbrek hastalığı olanlarda bu konu ile ilgili bir çalışma bulunmamaktadır. Biz de bu çalışmamızda periton diyalizi PD ve hemodiyaliz HD hastalarında periodontal parametreler ile serum lipid seviyeleri arasında ilişki olup olmadığını değerlendirmeyi amaçladık.YÖNTEMLER: Çalışmaya 54 periton diyalizi ve 40 hemodiyaliz hastası dahil edildi. Tüm hastalara değerlendirmeler yapılmadan 3 ay önce ağız hijyeni eğitimi verildi. Hastalar sağlıklı, gingivitis ve periodontitis olmak üzere 3 alt gruba ayrıldı. Hastaların plak indeksi Pİ , gingival indeks Gİ , sondalanabilir cep derinlikleri SCD , klinik ataşman seviyeleri KAS ve DMFT skorları kaydedildi. Hastalardan venöz kan örnekleri alınarak serum total kolesterol TKol , düşük dansiteli lipoprotein LDL , yüksek dansiteli lipoprotein HDL ve trigliserit düzeylerine bakıldı. BULGULAR: Çalışmamızda HD ve PD grupları arasında DMFT skorları istatistiksel olarak farklılık göstermemektedir p>0,05 . HD ve PD hastalarında serum lipid seviyeleri ile periodontal hastalıklar arasında ilişki bulunamamıştır. p>0,05 . Serum lipidlerinin ortalama değerleri gruplar arasında ve her bir alt grupta farklılık gösterse de bu fark istatistiksel olarak anlamlı değildi p>0,05 . SONUÇ: Literatürde sağlıklı bireylerde periodontal hastalık varlığı ile serum lipid değerleri arasında anlamlı bir ilişki bulunmuş olmasına rağmen bizim çalışmamızda diyaliz hastalarında periodontal hastalık ile serum lipid seviyeleri arasında bir ilişki bulunamamıştır.

References

  • 1. Craig RG. Interactions between chronic renal disease and periodontal disease. Oral Dis 2008;14:1- 7.
  • 2. Gudapati A, Ahmed P, Rada R. Dental management of patients with renal failure. Gen Dent 2002;50:508-10.
  • 3. Craig RG, Spittle MA, Levin NW. Importance of periodontal disease in the kidney patient. Blood Purif 2002;20:113-9.
  • 4. Kotanko P. Chronic inflammation in dialysis patients - periodontal disease, the new kid on the block. Oral Dis;2008:14:8-9.
  • 5. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997;350:430-6.
  • 6. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366: 1809-20.
  • 7. D'Aiuto F, Ready D, Tonetti MS. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res 2004;39:236-41.
  • 8. Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim BO, Nares S, Iacopino AM. Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 1999;70:1429-34.
  • 9. Losche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000; 27:537-41.
  • 10. Fentoglu O, Oz G, Tasdelen P, Uskun E, Aykac Y, Bozkurt FY. Periodontal status in subjects with hyperlipidemia. J Periodontol 2009;80:267-73.
  • 11. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Ann Periodontol 2003;8 54-69.
  • 12. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003;8:38-53.
  • 13. Bots CP, Poorterman JH, Brand HS, Kalsbeek H, van Amerongen BM, Veerman EC, Nieuw Amerongen AV. The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy. Oral Dis 2006;12:176-80.
  • 14. Cengiz MI, Bal S, Gokcay S, Cengiz K. Does periodontal disease reflect atherosclerosis in continuous ambulatory peritoneal dialysis patients? J Periodontol 2007;78:1926-34.
  • 15. Bayraktar G, Kurtulus I, Kazancioglu R, Bayramgurler I, Cintan S, Bural C, Bozfakioglu S, Besler M, Trablus S, Issever H, Yildiz A. Evaluation of periodontal parameters in patients undergoing peritoneal dialysis or hemodialysis. Oral Dis 2008; 14:185- 9.
  • 16. Clark DB. Dental findings in patients with chronic renal failure. An overview. J Can Dent Assoc 1987;53:781-5.
  • 17. Silness J, Loe H. Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condtion. Acta Odontol Scand 1964;22:121-35.
  • 18. Loe H, Silness J. Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontol Scand, 1963;21:533-51.
  • 19. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
  • 20. Noack B, Jachmann I, Roscher S, Sieber L, Kopprasch S, Luck C, Hanefeld M, Hoffmann T. Metabolic diseases and their possible link to risk indicators of periodontitis. J Periodontol 2000;71:898-903.
  • 21. Tsumura M, Kinouchi T, Ono S, Nakajima T, Komoda T. Serum lipid metabolism abnormalities and change in lipoprotein contents in patients with advanced-stage renal disease. Clin Chim Acta 2001;314:27-37.
  • 22. Shoji T, Ishimura E, Inaba M, Tabata T, Nishizawa Y. Atherogenic lipoproteins in end-stage renal disease. Am J Kidney Dis 2001; 38:30-3.
  • 23. Chmielewski M, Carrero JJ, Nordfors L, Lindholm B, Stenvinkel P. Lipid disorders in chronic kidney disease: reverse epidemiology and therapeutic approach. J Nephrol 2008;21:635-44.
  • 24. Stenvinkel P, Heimburger O, Lindholm B, Kaysen GA, Bergstrom J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 2000;15:953-60.
  • 25. Castledine C, van Schalkwyk D, Feest T, Steenkamp R, Dawnay A. UK Renal Registry 13th Annual Report (December 2010): Chapter 10: calcium, phosphate, parathyroid hormone, bicarbonate and total cholesterol concentrations amongst patients receiving haemodialysis or peritoneal dialysis in England, Wales and Northern Ireland in 2009: nati-onal and centre-specific analyses. Nephron Clin Pract 2011;119 (Suppl 2): c179-214.
  • 26. Penumarthy S, Penmetsa GS, Mannem S. Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients. J Indian Soc Periodontol 2013;17:30-5.
  • 27. Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 2002;73:494-500.
  • 28. Fentoglu O, Koroglu BK, Hicyilmaz H, Sert T, Ozdem M, Sutcu R, Tamer MN, Orhan H, Ay ZY, Ozturk Tonguc M, Kirzioglu FY. Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. J Clin Periodontol 2011; 38: 8-16.
  • 29. Katz J, Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol 2001;28: 865-8.
  • 30. Maglakelidze N, Galogre A, Tsagareli Z. Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia. Georgian Med News 2005;121:71-4.
There are 30 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Gülnihal Emrem Doğan This is me

Hülya Aksoy This is me

Mustafa Keleş This is me

Publication Date May 1, 2014
Published in Issue Year 2014

Cite

APA Doğan, G. E., Aksoy, H., & Keleş, M. (2014). Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki. Abant Medical Journal, 3(2), 128-133. https://doi.org/10.5505/abantmedj.2014.50570
AMA Doğan GE, Aksoy H, Keleş M. Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki. Abant Med J. May 2014;3(2):128-133. doi:10.5505/abantmedj.2014.50570
Chicago Doğan, Gülnihal Emrem, Hülya Aksoy, and Mustafa Keleş. “Periton Diyalizi Ve Hemodiyaliz Hastalarında Periodontal Hastalık Ile Serum Lipid Seviyeleri Arasındaki İlişki”. Abant Medical Journal 3, no. 2 (May 2014): 128-33. https://doi.org/10.5505/abantmedj.2014.50570.
EndNote Doğan GE, Aksoy H, Keleş M (May 1, 2014) Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki. Abant Medical Journal 3 2 128–133.
IEEE G. E. Doğan, H. Aksoy, and M. Keleş, “Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki”, Abant Med J, vol. 3, no. 2, pp. 128–133, 2014, doi: 10.5505/abantmedj.2014.50570.
ISNAD Doğan, Gülnihal Emrem et al. “Periton Diyalizi Ve Hemodiyaliz Hastalarında Periodontal Hastalık Ile Serum Lipid Seviyeleri Arasındaki İlişki”. Abant Medical Journal 3/2 (May 2014), 128-133. https://doi.org/10.5505/abantmedj.2014.50570.
JAMA Doğan GE, Aksoy H, Keleş M. Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki. Abant Med J. 2014;3:128–133.
MLA Doğan, Gülnihal Emrem et al. “Periton Diyalizi Ve Hemodiyaliz Hastalarında Periodontal Hastalık Ile Serum Lipid Seviyeleri Arasındaki İlişki”. Abant Medical Journal, vol. 3, no. 2, 2014, pp. 128-33, doi:10.5505/abantmedj.2014.50570.
Vancouver Doğan GE, Aksoy H, Keleş M. Periton Diyalizi ve Hemodiyaliz Hastalarında Periodontal Hastalık ile Serum Lipid Seviyeleri Arasındaki İlişki. Abant Med J. 2014;3(2):128-33.