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The Effect of GSTT-1 and GSTM-1 Gene Deletions on Gastric Cancer Development Risk

Year 2021, , 226 - 230, 31.08.2021

Ömer Faruk Bük , Sönmez Ocak

https://doi.org/10.47493/abantmedj.852513

Abstract

References

  • 1-Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H. Gastric cancer. Lancet. 2016 Nov 26;388(10060):2654-2664.
  • 2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.
  • 3-Bornschein J, Selgrad M, Warnecke M, Kuester D, Wex T, Malfertheiner P. H. pylori infection is a key risk factor for proximal gastric cancer. Dig Dis Sci. 2010; 55: 3124-31.
  • 4- Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F. Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol 2015; 16: e60–70.
  • 5- Blair V, Martin I, Shaw D, Winship I, Kerr D, Arnold J, ve ark. Hereditary diffuse gastric cancer: diagnosis and management. Clin Gastroenterol Hepatol. 2006 ;4(3):262-75.
  • 6- Lunet N, Valbuena C, Vieira AL, Lopes C, Lopes C, David L, ve ark. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27.
  • 7- Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, ve ark. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008 ;19(7):689-701.
  • 8- Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, ve ark. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009 Nov;45(16):2867-73.
  • 9-Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30(6):445-600.
  • 10-de Bruin WC, Wagenmans MJ, Peters WH. Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. Jpn J Cancer Res. 2000 ;91(3):310-6.
  • 11-García-González MA, Quintero E, Bujanda L, Nicolás D, Benito R, Strunk M, ve ark. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype. Mutagenesis. 2012 ;27(6):771-7.
  • 12-Boccia S, Sayed-Tabatabaei FA, Persiani R, Gianfagna F, Rausei S, Arzani D, ve ark. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. BMC Cancer. 2007 ;7:206.
  • 13-Chen B, Cao L, Zhou Y, Yang P, Wan HW, Jia GQ, ve ark. Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiologic studies. Dig Dis Sci. 2010 ;55(7):1831-8.
  • 14-Masoudi M, Saadat I, Omidvari S, Saadat M. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. Mol Biol Rep. 2009;36(4):781-4.
  • 15-Piao JM, Shin MH, Kweon SS, Kim HN, Choi JS, Bae WK, ve ark. Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. World J Gastroenterol. 2009;15(45):5716-21.
  • 16- La Torre G, Boccia S, Ricciardi G. Glutathione S-transferase M1 status and gastric cancer risk: a meta-analysis. Cancer Lett. 2005 ;217(1):53-60.
  • 17- Ribeiro RX, Nascimento CILL, Silva AMTC. GENOTYPE ASSOCIATION GSTM1 NULL AND GASTRIC CANCER: EVIDENCE-BASED META-ANALYSIS. Arq Gastroenterol. 2017 ;54(2):101-108.
  • 18- Tamer L, Ateş NA, Ateş C, Ercan B, Elipek T, Yildirim H, ve ark. Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk. Cell Biochem Funct. 2005; 23(4):267-72.
  • 19- Chen ZH, Xian JF, Luo LP. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors. Genet Mol Res. 2017 ;16(1).
  • 20- Hidaka A, Sasazuki S, Matsuo K, Ito H, Charvat H, Sawada ve ark. JPHC Study Group. CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study. Int J Cancer. 2016 ;139(4):759-68.
  • 21- Li XM, Yu XW, Yuan Y, Pu MZ, Zhang HX, Wang KJ, ve ark. Glutathione S-transferase P1, gene-gene interaction, and lung cancer susceptibility in the Chinese population: An updated meta-analysis and review. J Cancer Res Ther. 2015 ;11(3):565-70.
  • 22- Zeng Y, Bai J, Deng LC, Xie YP, Zhao F, Huang Y. Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations. Asian Pac J Cancer Prev. 2016;17(3):1141-8.
  • 23- Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, et al. Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies. Nutr Cancer. 2016;68(1):40-7.
  • 24- Larsson SC, Giovannucci E, Wolk A. Coffee consumption and stomach cancer risk in a cohort of Swedish women. Int J Cancer. 2006 ;119(9):2186-9.
  • 25- Kim H, Keum N, Giovannucci EL, Fuchs CS, Bao Y. Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer. 2018;143(5):1047-1053.
  • 26- Parra-Lara LG, Mendoza-Urbano DM, Bravo JC, Salamanca CH, Zambrano AR. Coffee Consumption, Antioxidant Properties and Stomach Cancer. Preprints 2020, 2020050280

GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi

Year 2021, , 226 - 230, 31.08.2021

Ömer Faruk Bük , Sönmez Ocak

https://doi.org/10.47493/abantmedj.852513

Abstract

Amaç:
Mide kanseri tüm dünyada en sık görülen kanserlerden olup erken tespiti ve risk faktörlerinin kontrolü en etkin korunma yöntemi olmaktadır. Değişik genlerin spesifik varyant alellerine bağlı genetik yatkınlık çevresel maruziyetin etkisini modifiye edebilmektedir. Bu çalışmada GSTT-1 ve GSTM-1 gen delesyonlarının mide kanseri üzerindeki etkileri araştırılmıştır.
Hastalar ve yöntem: Bu çalışmaya, Ankara Üniversitesi Tıp Fakültesi Genel Cerrahi Kliniğine Mide Adenokanseri tanısı alan 61 hasta vaka grubu olarak , endoskopi ünitesine üst Gastrointestinal sistem endoskopisi yaptırmak için başvuran 61 hasta kontrol grubu olmak üzere toplamda 122 hasta dahil edildi. Vaka ve kontrol grubuna ait parafin doku örnekelerinden sıvı DNA izole edildi. Sıvı formdaki DNA’lardan PCR yapılarak GSTT-1 ve GSTM-1 gen delesyonu durumuna bakıldı.
Bulgular: Vaka grubunda tümöral ve normal dokuların GSTT-1 ve GSTM-1 gen delesyonu durumuna göre karşılaştırılmasında anlamlı bir fark ortaya çıkmadı. Vaka grubu tümöral ve normal dokularının GSTT-1 ve GSTM-1 gen delesyonu durumu ile kontrol grubu GSTT-1 ve GSTM-1 gen delesyonu durumu arasında anlamlı bir fark ortaya çıkmadı.
Sonuç: Bu çalışmada GSTT-1 gen delesyonu ya da GSTM-1 gen delesyonu ile mide kanseri arasında anlamlı bir ilişki bulunamamıştır.

Keywords

GSTT-1 GSTM-1 mide kanseri

References

  • 1-Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H. Gastric cancer. Lancet. 2016 Nov 26;388(10060):2654-2664.
  • 2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.
  • 3-Bornschein J, Selgrad M, Warnecke M, Kuester D, Wex T, Malfertheiner P. H. pylori infection is a key risk factor for proximal gastric cancer. Dig Dis Sci. 2010; 55: 3124-31.
  • 4- Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F. Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol 2015; 16: e60–70.
  • 5- Blair V, Martin I, Shaw D, Winship I, Kerr D, Arnold J, ve ark. Hereditary diffuse gastric cancer: diagnosis and management. Clin Gastroenterol Hepatol. 2006 ;4(3):262-75.
  • 6- Lunet N, Valbuena C, Vieira AL, Lopes C, Lopes C, David L, ve ark. Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 2007;16(4):312-27.
  • 7- Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, ve ark. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008 ;19(7):689-701.
  • 8- Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, ve ark. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009 Nov;45(16):2867-73.
  • 9-Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30(6):445-600.
  • 10-de Bruin WC, Wagenmans MJ, Peters WH. Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. Jpn J Cancer Res. 2000 ;91(3):310-6.
  • 11-García-González MA, Quintero E, Bujanda L, Nicolás D, Benito R, Strunk M, ve ark. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype. Mutagenesis. 2012 ;27(6):771-7.
  • 12-Boccia S, Sayed-Tabatabaei FA, Persiani R, Gianfagna F, Rausei S, Arzani D, ve ark. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. BMC Cancer. 2007 ;7:206.
  • 13-Chen B, Cao L, Zhou Y, Yang P, Wan HW, Jia GQ, ve ark. Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiologic studies. Dig Dis Sci. 2010 ;55(7):1831-8.
  • 14-Masoudi M, Saadat I, Omidvari S, Saadat M. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. Mol Biol Rep. 2009;36(4):781-4.
  • 15-Piao JM, Shin MH, Kweon SS, Kim HN, Choi JS, Bae WK, ve ark. Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. World J Gastroenterol. 2009;15(45):5716-21.
  • 16- La Torre G, Boccia S, Ricciardi G. Glutathione S-transferase M1 status and gastric cancer risk: a meta-analysis. Cancer Lett. 2005 ;217(1):53-60.
  • 17- Ribeiro RX, Nascimento CILL, Silva AMTC. GENOTYPE ASSOCIATION GSTM1 NULL AND GASTRIC CANCER: EVIDENCE-BASED META-ANALYSIS. Arq Gastroenterol. 2017 ;54(2):101-108.
  • 18- Tamer L, Ateş NA, Ateş C, Ercan B, Elipek T, Yildirim H, ve ark. Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk. Cell Biochem Funct. 2005; 23(4):267-72.
  • 19- Chen ZH, Xian JF, Luo LP. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors. Genet Mol Res. 2017 ;16(1).
  • 20- Hidaka A, Sasazuki S, Matsuo K, Ito H, Charvat H, Sawada ve ark. JPHC Study Group. CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study. Int J Cancer. 2016 ;139(4):759-68.
  • 21- Li XM, Yu XW, Yuan Y, Pu MZ, Zhang HX, Wang KJ, ve ark. Glutathione S-transferase P1, gene-gene interaction, and lung cancer susceptibility in the Chinese population: An updated meta-analysis and review. J Cancer Res Ther. 2015 ;11(3):565-70.
  • 22- Zeng Y, Bai J, Deng LC, Xie YP, Zhao F, Huang Y. Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations. Asian Pac J Cancer Prev. 2016;17(3):1141-8.
  • 23- Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, et al. Coffee consumption and the risk of incident gastric cancer--A meta-analysis of prospective cohort studies. Nutr Cancer. 2016;68(1):40-7.
  • 24- Larsson SC, Giovannucci E, Wolk A. Coffee consumption and stomach cancer risk in a cohort of Swedish women. Int J Cancer. 2006 ;119(9):2186-9.
  • 25- Kim H, Keum N, Giovannucci EL, Fuchs CS, Bao Y. Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer. 2018;143(5):1047-1053.
  • 26- Parra-Lara LG, Mendoza-Urbano DM, Bravo JC, Salamanca CH, Zambrano AR. Coffee Consumption, Antioxidant Properties and Stomach Cancer. Preprints 2020, 2020050280
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Ömer Faruk Bük 0000-0003-4559-2735

Sönmez Ocak 0000-0001-9550-4268

Publication Date August 31, 2021
Submission Date January 2, 2021
Published in Issue Year 2021

Cite

APA Bük, Ö. F., & Ocak, S. (2021). GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi. Abant Medical Journal, 10(2), 226-230. https://doi.org/10.47493/abantmedj.852513
AMA Bük ÖF, Ocak S. GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi. Abant Med J. August 2021;10(2):226-230. doi:10.47493/abantmedj.852513
Chicago Bük, Ömer Faruk, and Sönmez Ocak. “GSTT-1 Ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi”. Abant Medical Journal 10, no. 2 (August 2021): 226-30. https://doi.org/10.47493/abantmedj.852513.
EndNote Bük ÖF, Ocak S (August 1, 2021) GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi. Abant Medical Journal 10 2 226–230.
IEEE Ö. F. Bük and S. Ocak, “GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi”, Abant Med J, vol. 10, no. 2, pp. 226–230, 2021, doi: 10.47493/abantmedj.852513.
ISNAD Bük, Ömer Faruk - Ocak, Sönmez. “GSTT-1 Ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi”. Abant Medical Journal 10/2 (August 2021), 226-230. https://doi.org/10.47493/abantmedj.852513.
JAMA Bük ÖF, Ocak S. GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi. Abant Med J. 2021;10:226–230.
MLA Bük, Ömer Faruk and Sönmez Ocak. “GSTT-1 Ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi”. Abant Medical Journal, vol. 10, no. 2, 2021, pp. 226-30, doi:10.47493/abantmedj.852513.
Vancouver Bük ÖF, Ocak S. GSTT-1 ve GSTM-1 Gen Delesyonlarının Mide Kanseri Gelişim Riski Üzerine Etkisi. Abant Med J. 2021;10(2):226-30.